Results 41 to 50 of about 29,008 (251)

Highlights in Purinergic Signalling [PDF]

Purinergic Signalling, 2009
It has become increasingly clear that receptors and ion channels in the plasma membrane do not exist and function in isolation, but instead form complexes with other proteins and this can modify their expression and activity. In this study, the authors determined which proteins complex with the P2X2 receptor and characterised the influence of one ...
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Purinergic signaling in epilepsy [PDF]

Journal of Neuroscience Research, 2016
Until recently, analysis of the mechanisms underlying epilepsy was centered on neuron dysfunctions. Accordingly, most of the available pharmacological treatments aim at reducing neuronal excitation or at potentiating neuronal inhibition. These therapeutic options can lead to obvious secondary effects, and, moreover, seizures cannot be controlled by any
Rassendren, François, Audinat, Etienne
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The Potential of Purinergic Signaling to Thwart Viruses Including SARS-CoV-2

Frontiers in Immunology, 2022
A long-shared evolutionary history is congruent with the multiple roles played by purinergic signaling in viral infection, replication and host responses that can assist or hinder viral functions.
Davide Ferrari, Davide Ferrari, Michele Rubini, Jorge S. Burns, Jorge S. Burns   +4 more
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Purinergic signalling in systemic sclerosis

Rheumatology, 2021
Abstract SSc is a chronic autoimmune rheumatic disease that involves numerous organs and presents major management challenges. The histopathologic hallmarks of SSc include vasculopathy, fibrosis and autoimmune phenomena involving both innate and adaptive immune systems.
Höppner, Jakob, Bruni, Cosimom, Distler, Oliver, Robson, Simon C, Burmester, Gerd R, Siegert, Elise, Distler, Jörg H W   +6 more
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Besnoitia besnoiti-induced neutrophil clustering and neutrophil extracellular trap formation depend on P2X1 purinergic receptor signaling

Frontiers in Immunology, 2023
Bovine besnoitiosis is a re-emerging cattle disease caused by the cyst-forming apicomplexan parasite Besnoitia besnoiti. Neutrophil extracellular trap (NET) formation represents an efficient innate immune mechanism of polymorphonuclear neutrophils (PMN ...
Gabriel Espinosa, Iván Conejeros, Lisbeth Rojas-Barón, Carlos Rodrigo Hermosilla, Anja Taubert   +4 more
doaj   +1 more source

The relationship between P2X4 and P2X7: a physiologically important interaction? [PDF]

, 2013
Purinergic signaling within the kidney is becoming an important focus in the study of renal health and disease. The effectors of ATP signaling, the P2Y and P2X receptors, are expressed to varying extents in and along the nephron.
Unwin, RJ, Eilidh eCraigie, Scott S Wildman, Wildman, Scott S.P., Eilidh Craigie, Rebecca E. Birch, Robert John Unwin, Craigie, Eilidh, Craigie, E, Rebecca E Birch, Unwin, Robert J., Unwin, Robert J, Birch, Rebecca E., Birch, RE, Robert J. Unwin, Wildman, SS, Scott S. Wildman, Birch, Rebecca E, Wildman, Scott   +18 more
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Purinergic signalling and diabetes [PDF]

Purinergic Signalling, 2013
The pancreas is an organ with a central role in nutrient breakdown, nutrient sensing and release of hormones regulating whole body nutrient homeostasis. In diabetes mellitus, the balance is broken-cells can be starving in the midst of plenty. There are indications that the incidence of diabetes type 1 and 2, and possibly pancreatogenic diabetes, is ...
Burnstock, G, Novak, I
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Purinergic signaling and purine base metabolism at the crossroads between immunity, metabolism, and cancer: A review

ImmunoMedicine, 2023
In addition to its universally known role in transferring genetic material, DNA nucleotides and nucleosides are regarded as the most ancient form of extracellular signaling molecules. This unique signaling pathway was first reported by Dr.
Delaney K. Geitgey, Anja J. Melendez, Raquel Caldeira‐Botelho, Melissa L. Kemp, Curtis J. Henry   +4 more
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Purinergic Signaling in Pathologic Osteogenic Differentiation of Aortic Valve Interstitial Cells from Patients with Aortic Valve Calcification

Biomedicines, 2023
Purinergic signaling is associated with a vast spectrum of physiological processes, including cardiovascular system function and, in particular, its pathological calcifications, such as aortic valve stenosis.
Polina Klauzen, Daria Semenova, Daria Kostina, Vladimir Uspenskiy, Anna Malashicheva   +4 more
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Exocytosis of ATP from astrocytes modulates phasic and tonic inhibition in the neocortex [PDF]

, 2014
Communication between neuronal and glial cells is important for many brain functions. Astrocytes can modulate synaptic strength via Ca2+-stimulated release of various gliotransmitters, including glutamate and ATP. A physiological role of ATP release from
Lalo, Ulyana, Pankratov, Yuriy, Palygin, Oleg, Oleg Palygin (407627), Philip G Haydon, Ulyana Lalo (506296), Yuriy Pankratov, Seyed Rasooli-Nejad (506297), Rasooli-Nejad, Seyed, Yuriy Pankratov (407630), Oleg Palygin, Ulyana Lalo, Haydon, Philip G., Jemma Andrew, Jemma Andrew (506298), Philip G. Haydon (506299), Andrew, Jemma, Seyed Rasooli-Nejad   +17 more
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