Results 41 to 50 of about 842,442 (245)
Frontiers in Neuroscience, 2023 Age-related macular degeneration (AMD) is a chronic and progressive inflammatory disease of the retina characterized by photoceptor loss and significant central visual impairment due to either choroidal neovascularization or geographic atrophy.
Haydn Molcak +3 more
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Purinergic Signaling in Bone [PDF]
Journal of Osteoporosis, 2013 In recent years, it has become apparent that extracellular nucleotides, signalling via P2 receptors, play an important role in the regulation of bone turnover. Furthermore, purinergic signalling has been associated in the pathophysiology of several bone and cartilage diseases, including osteoarthritis, rheumatoid arthritis, and osteoporosis and might ...
Niklas Rye Jørgensen +3 more
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Purinergic signaling in epilepsy [PDF]
Journal of Neuroscience Research, 2016 Until recently, analysis of the mechanisms underlying epilepsy was centered on neuron dysfunctions. Accordingly, most of the available pharmacological treatments aim at reducing neuronal excitation or at potentiating neuronal inhibition. These therapeutic options can lead to obvious secondary effects, and, moreover, seizures cannot be controlled by any
Rassendren, François, Audinat, Etienne
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Purinergic signalling and diabetes [PDF]
Purinergic Signalling, 2013 The pancreas is an organ with a central role in nutrient breakdown, nutrient sensing and release of hormones regulating whole body nutrient homeostasis. In diabetes mellitus, the balance is broken-cells can be starving in the midst of plenty. There are indications that the incidence of diabetes type 1 and 2, and possibly pancreatogenic diabetes, is ...
Burnstock, G, Novak, I
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The Role of Purinergic Signaling in Heart Transplantation
Frontiers in Immunology, 2022 Heart transplantation remains the optimal treatment option for patients with end-stage heart disease. Growing evidence demonstrates that purinergic signals mediated by purine nucleotides and nucleosides play vital roles in heart transplantation ...
Yanzhi Jiang +3 more
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Purinergic Signaling in Ovarian Carcinoma. [PDF]
Adv Pharm BullOvarian carcinoma (OC) is the most lethal gynecological cancer worldwide. Around 95% of patients exhibit recurrence five years after treatment; 80% experience recurrence within 18 months after first-line treatment, and progression-free survival rates have not changed over the past 40 years. New therapeutic approaches are imperative to face this complex
Martínez-Ramírez AS +4 more
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Purinergic signaling in the ovary [PDF]
Molecular Reproduction and Development, 2015 SUMMARYAdenosine triphosphate (ATP) is released from the cell by multiple mechanisms. The extracellular form of this purine is processed by ectonucleotidases, resulting in a variety of dephosphorylated metabolites that can bind to specific receptors found in the membrane of target cells; such purinergic signaling is important as an autocrine‐paracrine ...
Angélica S, Martínez-Ramírez +1 more
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Purinergic signalling and cancer [PDF]
Purinergic Signalling, 2013 Receptors for extracellular nucleotides are widely expressed by mammalian cells. They mediate a large array of responses ranging from growth stimulation to apoptosis, from chemotaxis to cell differentiation and from nociception to cytokine release, as well as neurotransmission.
Burnstock G, DI VIRGILIO, Francesco
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Mitochondria Synergize With P2 Receptors to Regulate Human T Cell Function
Frontiers in Immunology, 2020 Intracellular ATP is the universal energy carrier that fuels many cellular processes. However, immune cells can also release a portion of their ATP into the extracellular space.
Carola Ledderose, Wolfgang G. Junger
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Purinergic signaling in the male reproductive tract
Frontiers in Endocrinology, 2022 Purinergic receptors are ubiquitously expressed throughout the body and they participate in the autocrine and paracrine regulation of cell function during normal physiological and pathophysiological conditions.
Larissa Berloffa Belardin +4 more
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