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Purinergic signaling in the gastrointestinal tract [PDF]
, 2011 Geoffrey Burnstock completed a BSc at King's College London and a PhD at University College London. He held postdoctoral fellowships with Wilhelm Feldberg (National Institute for Medical Research), Edith Bülbring (University of Oxford) and C.
Geoffrey Burnstock, Burnstock, G
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British Journal of Pharmacology, 2006 While there were early papers about the extracellular actions of purines, the role of ATP as a purinergic neurotransmitter in nonadrenergic, noncholinergic nerves in the gut and bladder in 1972 was a landmark discovery, although it met considerable resistance for the next 20 years. In the early 1990s, receptors for purines were cloned: four P1 receptor
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Purine and purinergic receptors in health and disease
MedComm, 2023 Purines and purinergic receptors are widely distributed throughout the human body. Purine molecules within cells play crucial roles in regulating energy metabolism and other cellular processes, while extracellular purines transmit signals through ...
Yanling Ai +6 more
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Highlights in Purinergic Signalling [PDF]
Purinergic Signalling, 2009 It has become increasingly clear that receptors and ion channels in the plasma membrane do not exist and function in isolation, but instead form complexes with other proteins and this can modify their expression and activity. In this study, the authors determined which proteins complex with the P2X2 receptor and characterised the influence of one ...
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The Potential of Purinergic Signaling to Thwart Viruses Including SARS-CoV-2
Frontiers in Immunology, 2022 A long-shared evolutionary history is congruent with the multiple roles played by purinergic signaling in viral infection, replication and host responses that can assist or hinder viral functions.
Davide Ferrari +4 more
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The relationship between P2X4 and P2X7: a physiologically important interaction? [PDF]
, 2013 Purinergic signaling within the kidney is becoming an important focus in the study of renal health and disease. The effectors of ATP signaling, the P2Y and P2X receptors, are expressed to varying extents in and along the nephron.
Unwin, RJ +18 more
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Exocytosis of ATP from astrocytes modulates phasic and tonic inhibition in the neocortex [PDF]
, 2014 Communication between neuronal and glial cells is important for many brain functions. Astrocytes can modulate synaptic strength via Ca2+-stimulated release of various gliotransmitters, including glutamate and ATP. A physiological role of ATP release from
Lalo, Ulyana +17 more
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Frontiers in Immunology, 2023 Bovine besnoitiosis is a re-emerging cattle disease caused by the cyst-forming apicomplexan parasite Besnoitia besnoiti. Neutrophil extracellular trap (NET) formation represents an efficient innate immune mechanism of polymorphonuclear neutrophils (PMN ...
Gabriel Espinosa +4 more
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Purinergic signalling in systemic sclerosis
Rheumatology, 2021 Abstract SSc is a chronic autoimmune rheumatic disease that involves numerous organs and presents major management challenges. The histopathologic hallmarks of SSc include vasculopathy, fibrosis and autoimmune phenomena involving both innate and adaptive immune systems.
Höppner, Jakob +6 more
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New insights into purinergic receptor signaling in neuronal differentiation, neuroprotection, and brain disorders [PDF]
, 2007 Ionotropic P2X and metabotropic P2Y purinergic receptors are expressed in the central nervous system and participate in the synaptic process particularly associated with acetylcholine, GABA, and glutamate neurotransmission. As a result of activation, the
Trujillo, Cleber Augusto +15 more
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