To Inhibit or Enhance? Is There a Benefit to Positive Allosteric Modulation of P2X Receptors? [PDF]
Frontiers in Pharmacology, 2020 The family of ligand-gated ion channels known as P2X receptors were discovered several decades ago. Since the cloning of the seven P2X receptors (P2X1-P2X7), a huge research effort has elucidated their roles in regulating a range of physiological and ...
Leanne Stokes +3 more
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P2X Receptors: Potential Therapeutic Targets for Symptoms Associated With Lung Cancer — A Mini Review [PDF]
Frontiers in Oncology, 2021 Symptoms associated with lung cancer mainly consist of cancer-associated pain, cough, fatigue, and dyspnea. However, underlying mechanisms of lung cancer symptom clusters remain unclear.
Yonglin Mai +5 more
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Activity of Peptides Modulating the Action of p2x Receptors: Focus on the p2x7 Receptor [PDF]
PharmaceuticalsP2X receptors are a family of ATP-gated ion channels widely distributed in various tissues, especially in neuronal cells and hematopoietic cells. ATP activates P2X receptors, causing the opening of an ionic channel with preferential permeability to the ...
Jonathas Albertino De Souza Oliveira Carneiro +3 more
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Activated P2X receptors can up-regulate the expressions of inflammation-related genes via NF-κB pathway in spotted sea bass (Lateolabrax maculatus) [PDF]
Frontiers in Immunology, 2023 P2X receptors, including seven subtypes, i.e., P2X1-7, are the ligand-gated ion channels activated by the extracellular ATP playing the critical roles in inflammation and immune response.
Zhaosheng Sun +13 more
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Pharmacology of P2X Receptors and Their Possible Therapeutic Potential in Obesity and Diabetes [PDF]
PharmaceuticalsThe role of P2X ionotropic receptors in the behavior of purinergic signaling on pathophysiological processes has been widely studied. In recent years, the important participation of P2X receptors in physiological and pathological processes, such as ...
Guillermo A. Cabral-García +5 more
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Enlightening activation gating in P2X receptors. [PDF]
Purinergic Signal, 2022 P2X receptors are trimeric nonselective cation channels gated by ATP. They assemble from seven distinct subunit isoforms as either homo- or heteromeric complexes and contain three extracellularly located binding sites for ATP. P2X receptors are expressed
Sattler C, Benndorf K.
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Subtype-Specific Ligand Binding and Activation Gating in Homomeric and Heteromeric P2X Receptors [PDF]
BiomoleculesP2X receptors are ATP-activated, non-specific cation channels involved in sensory signalling, inflammation, and certain forms of pain. Investigations of agonist binding and activation are essential for comprehending the fundamental mechanisms of receptor
Xenia Brünings +4 more
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The Molecular Determinants of Small-Molecule Ligand Binding at P2X Receptors [PDF]
Frontiers in Pharmacology, 2018 P2X receptors are trimeric eukaryotic ATP-gated cation channels. Extracellular ATP—their physiological ligand—is released as a neurotransmitter and in conditions of cell damage such as inflammation, and substantial evidence implicates P2X receptors in ...
Gaia Pasqualetto +2 more
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Structural insights into the orthosteric inhibition of P2X receptors by non-ATP analog antagonists [PDF]
eLifeP2X receptors are extracellular ATP-gated ion channels that form homo- or heterotrimers and consist of seven subtypes. They are expressed in various tissues, including neuronal and nonneuronal cells, and play critical roles in physiological processes ...
Danqi Sheng +7 more
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Modulation of Central Synapses by Astrocyte-Released ATP and Postsynaptic P2X Receptors [PDF]
Neural Plasticity, 2017 Communication between neuronal and glial cells is important for neural plasticity. P2X receptors are ATP-gated cation channels widely expressed in the brain where they mediate action of extracellular ATP released by neurons and/or glia.
Eric Boué-Grabot, Yuriy Pankratov
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