Results 1 to 10 of about 356 (90)

Direct observation of ATP-induced conformational changes in single P2X(4) receptors. [PDF]

PLoS Biology, 2009
The ATP-gated P2X(4) receptor is a cation channel, which is important in various pathophysiological events. The architecture of the P2X(4) receptor in the activated state and how to change its structure in response to ATP binding are not fully understood.
Youichi Shinozaki, Koji Sumitomo, Makoto Tsuda, Schuichi Koizumi, Kazuhide Inoue, Keiichi Torimitsu   +5 more
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To Inhibit or Enhance? Is There a Benefit to Positive Allosteric Modulation of P2X Receptors?

Frontiers in Pharmacology, 2020
The family of ligand-gated ion channels known as P2X receptors were discovered several decades ago. Since the cloning of the seven P2X receptors (P2X1-P2X7), a huge research effort has elucidated their roles in regulating a range of physiological and ...
Leanne Stokes, Stefan Bidula, Lučka Bibič, Elizabeth Allum   +3 more
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ATP signaling in the integrative neural center of Aplysia californica

Scientific Reports, 2021
ATP and its ionotropic P2X receptors are components of the most ancient signaling system. However, little is known about the distribution and function of purinergic transmission in invertebrates.
János Györi, Andrea B. Kohn, Daria Y. Romanova, Leonid L. Moroz   +3 more
doaj   +1 more source

Inhibitory role of supraspinal P2X₃/P2X_2/3 subtypes on nociception in rats

Molecular Pain, 2006
Extracellular ATP is known to mediate synaptic transmission as a neurotransmitter or a neuromodulator via ionotropic P2X and metabotropic P2Y receptors.
Satoh Masamichi, Minami Masabumi, Nakagawa Takayuki, Fukui Masato, Kaneko Shuji   +4 more
doaj   +1 more source

Molecular and Pharmacological Evidence for the Expression of Multiple Functional P2 Purinergic Receptors in Human Adipocytes

Molecules, 2022
Extracellular ATP exerts important functions as an extracellular signaling molecule via the activation of specific P2 purinergic receptors (P2X and P2Y).
Marco Rossato, Francesca Favaretto, Marnie Granzotto, Marika Crescenzi, Alessandra Boscaro, Angelo Di Vincenzo, Federico Capone, Edoardo Dalla Nora, Eva Zabeo, Roberto Vettor   +9 more
doaj   +1 more source

Identification of ionotrophic purinergic receptors in Huh-7 cells and their response towards structural proteins of HCV genotype 3a

Virology Journal, 2011
Hepatitis C virus (HCV) is a major health problem in developing countries including Pakistan. Chronic HCV infection results in progressive liver disease including fibrosis, cirrhosis, insulin resistance and eventually hepatocellular carcinoma (HCC ...
Fatima Kaneez, Butt Sadia, Mehmood Azra, Ashraf Javed, Idrees Muhammad, Manzoor Sobia, Akbar Haji, Rehaman Irshad U, Qadri Ishtiaq   +8 more
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Research progress in the role of P2X receptors in oral maxillofacial pain

口腔疾病防治, 2018
Oral maxillofacial pain is one of the most common symptoms that greatly influences patients′ quality of life. Infectious diseases, nerve injuries and tumors in the oromaxillofacial region can cause facial pain.
HE Lingkun, XIONG Wei
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Introduction and perspective, historical note

Frontiers in Cellular Neuroscience, 2013
P2 nucleotide receptors were proposed to consist of two subfamilies based on pharmacology in 1985, named P2X and P2Y receptors. Later, this was confirmed following cloning of the receptors for nucleotides and studies of transduction mechanisms in the ...
Geoffrey eBurnstock
doaj   +1 more source

Lack of neuroprotection in the absence of P2X7 receptors in toxin-induced animal models of Parkinson's disease

Molecular Neurodegeneration, 2011
Background Previous studies indicate a role of P2X7 receptors in processes that lead to neuronal death. The main objective of our study was to examine whether genetic deletion or pharmacological blockade of P2X7 receptors influenced dopaminergic cell ...
Kittel Ágnes, Madarász Emilia, Gölöncsér Flóra, Csölle Cecilia, Baranyi Mária, Hracskó Zsuzsanna, Sperlágh Beáta   +6 more
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Comparison of P2X and TRPV1 receptors in ganglia or primary culture of trigeminal neurons and their modulation by NGF or serotonin

Molecular Pain, 2006
Background Cultured sensory neurons are a common experimental model to elucidate the molecular mechanisms of pain transduction typically involving activation of ATP-sensitive P2X or capsaicin-sensitive TRPV1 receptors.
Giniatullin Rashid, Nistri Andrea, Zweyer Marina, D'Arco Marianna, Fabbro Alessandra, Simonetti Manuela, Fabbretti Elsa   +6 more
doaj   +1 more source