Results 31 to 40 of about 13,556 (211)

Coexpression of rat P2X2 and P2X6 subunits in Xenopus oocytes. [PDF]

, 2000
Transcripts for P2X(2) and P2X(6) subunits are present in rat CNS and frequently colocalize in the same brainstem nuclei. When rat P2X(2) (rP2X(2)) and rat P2X(6) (rP2X(6)) receptors were expressed individually in Xenopus oocytes and studied under ...
B. F. King, Burnstock, G., Wildman, Scott S.P., Townsend-Nicholson, A., Spyer, K. M., King, B F, A. Townsend-Nicholson, Thomas, T., G. Burnstock, Wildman, S. S., Thomas, T, King, B. F., Townsend-Nicholson, A, Burnstock, G, S. S. Wildman, Spyer, K M, T. Thomas, K. M. Spyer   +17 more
core   +1 more source

Subunit Arrangement in P2X Receptors [PDF]

The Journal of Neuroscience, 2003
ATP-gated ionotropic receptors (P2X receptors) are distributed widely in the nervous system. For example, a hetero-oligomeric receptor containing both P2X2and P2X3subunits is involved in primary afferent sensation. Each subunit has two membrane-spanning domains.
Jiang, Lin Hua, Kim, Miran, Spelta, Valeria, Bo, Xuenong, Surprenant, Annmarie, North, R. Ala   +5 more
openaire   +3 more sources

Comparison of P2X and TRPV1 receptors in ganglia or primary culture of trigeminal neurons and their modulation by NGF or serotonin

Molecular Pain, 2006
Background Cultured sensory neurons are a common experimental model to elucidate the molecular mechanisms of pain transduction typically involving activation of ATP-sensitive P2X or capsaicin-sensitive TRPV1 receptors.
Giniatullin Rashid, Nistri Andrea, Zweyer Marina, D'Arco Marianna, Fabbro Alessandra, Simonetti Manuela, Fabbretti Elsa   +6 more
doaj   +1 more source

The relationship between P2X4 and P2X7: a physiologically important interaction? [PDF]

, 2013
Purinergic signaling within the kidney is becoming an important focus in the study of renal health and disease. The effectors of ATP signaling, the P2Y and P2X receptors, are expressed to varying extents in and along the nephron.
Unwin, RJ, Eilidh eCraigie, Scott S Wildman, Wildman, Scott S.P., Eilidh Craigie, Rebecca E. Birch, Robert John Unwin, Craigie, Eilidh, Craigie, E, Rebecca E Birch, Unwin, Robert J., Unwin, Robert J, Birch, Rebecca E., Birch, RE, Robert J. Unwin, Wildman, SS, Scott S. Wildman, Birch, Rebecca E, Wildman, Scott   +18 more
core   +1 more source

Expression of P2 receptors in human B cells and Epstein-Barr virus-transformed lymphoblastoid cell lines

BMC Immunology, 2006
Background Epstein-Barr virus (EBV) infection immortalizes primary B cells in vitro and generates lymphoblastoid cell lines (LCLs), which are used for several purposes in immunological and genetic studies. Purinergic receptors, consisting of P2X and P2Y,
Kim Jun Woo, Kong In Deok, Park Kyu Sang, Lee Dong Hyeon, Han Bok Ghee   +4 more
doaj   +1 more source

An evolutionary history of P2X receptors [PDF]

Purinergic Signalling, 2008
Adenosine triphosphate (ATP) is an ancient and fundamentally important biological molecule involved in both intracellular and extracellular activities. P2X ionotropic and P2Y metabotropic receptors have been cloned and characterised in mammals. ATP plays a central physiological role as a transmitter molecule in processes including the sensation of pain,
Fountain, Samuel J., Burnstock, Geoffrey
openaire   +3 more sources

P2 receptor mRNA expression profiles in human lymphocytes, monocytes and CD34+ stem and progenitor cells

BMC Immunology, 2004
Background Extracellular nucleotides (ATP, ADP, UTP and UDP) exert a wide range of biological effects in blood cells mediated by multiple ionotropic P2X receptors and G protein-coupled P2Y receptors.
Bengtsson Anders, Jacobsen Sten Eirik W, Wang Lingwei, Erlinge David   +3 more
doaj   +1 more source

Synthesis and Structure-Activity Relationships of Pyridoxal-6-arylazo-5'-phosphate and Phosphonate Derivatives as P2 Receptor Antagonists. [PDF]

, 1998
Novel analogs of the P2 receptor antagonist pyridoxal-5'-phosphate-6-phenylazo-2',4'-disulfonate (PPADS) were synthesized. Modifications were made through functional group substitution on the sulfophenyl ring and at the phosphate moiety through the ...
B. F. King, H. Kim, Ji, Xiao-Duo, Camaioni, Emidio, King, Brian F., A. Rychkov, A. Bartolini, Boyer, Jos L., Waktolla, GF, Mohanram, Arvind, F. Giuliani, K. A. Jacobson, Jacobson, Kenneth A., Y. C. Kim, Burnstock, Geoffrey, Park, HS, J. L. Boyer, Ziganshin, Airat U., S. S. Wildman, Harden, T. Kendall, Yoburn, Joshua, N. Galeotti, Galeotti, Nicoletta, Kass, GEN, A. U. Ziganshin, J.o. Yoburn, Sarkardei, S, C. Ghelardini, Tennant, JP, Wildman, Scott S.P., Rychkov, Alexei, T. K. Harden, G. Burnstock, Kim, Heaok, D. Barlocco, Bartolini, Alessandro, Kim, Yong-Chul, Boyer, José L., Ghelardini, Carla, Wildman, Scott S., Hourani, SMO, A. Mohanram, X. D. Ji   +42 more
core   +1 more source

PRIMITIVE ATP-ACTIVATED P2X RECEPTORS: DISCOVERY, FUNCTION AND PHARMACOLOGY

Frontiers in Cellular Neuroscience, 2013
Adenosine 5-triphosphate (ATP) is omnipresent in biology. It is therefore no surprise that organisms have evolved multifaceted roles for ATP, exploiting its abundance and restriction of passive diffusion across biological membranes.
Samuel J Fountain
doaj   +1 more source

Familial hemiplegic migraine Ca_V2.1 channel mutation R192Q enhances ATP-gated P2X₃ receptor activity of mouse sensory ganglion neurons mediating trigeminal pain

Molecular Pain, 2010
Background The R192Q mutation of the CACNA1A gene, encoding for the α1 subunit of voltage-gated P/Q Ca2+ channels (Cav2.1), is associated with familial hemiplegic migraine-1.
Nair Asha, Simonetti Manuela, Birsa Nicol, Ferrari Michel D, van den Maagdenberg Arn MJM, Giniatullin Rashid, Nistri Andrea, Fabbretti Elsa   +7 more
doaj   +1 more source