Results 51 to 60 of about 689,514 (206)
Regulatory interdependence of cloned epithelial Na+ channels and P2X receptors. [PDF]
, 2005 Epithelial Na+ channels (ENaC) coexist with a family of ATP-gated ion channels known as P2X receptors in the renal collecting duct. Although ENaC is itself insensitive to extracellular ATP, tubular perfusion of ATP can modify the activity of ENaC.
King, Brian F. +28 more
core +1 more source
Controlling Engineered P2X Receptors with Light [PDF]
, 2020 This chapter details methods to express and modify ATP-gated P2X receptor channels so that they can be controlled using light. Following expression in cells, a photoswitchable tool compound can be used to covalently modify mutant P2X receptors, as ...
Browne, LE, Chudasama, V, Atkinson, BN
core +1 more source
Repurposing antimicrobial agents for neuroprotection: Mechanisms, clinical potential, and challenges
Neuroprotection, EarlyView.Antimicrobial agents exert neuroprotective effects through modulation of interconnected pathways. Tetracyclines, macrolides, antimalarial agents, sulfones, and antiparasitic agents suppress neuroinflammation, oxidative stress, and apoptosis while preserving mitochondrial function and neurotransmission.
Mohammad Amin Manavi +5 more
wiley +1 more source
P2X₃ Knock-Out Mice Reveal a Major Sensory Role for Urothelially Released ATP [PDF]
, 2001 The present study explores the possible involvement of a purinergic mechanism in mechanosensory transduction in the bladder using P2X₃ receptor knock-out (P2X₃ ⁻⁄⁻) and wild-type control (P2X₃ ⁺⁄⁺) mice.
Bodin, P +7 more
core
Cell Transplantation, 2015 Spinal cord injury (SCI) is a major cause of paralysis with no current therapies. Following SCI, large amounts of ATP and other nucleotides are released by the traumatized tissue leading to the activation of purinergic receptors that, in coordination ...
Rosa Gómez-Villafuertes Ph.D. +5 more
doaj +1 more source
Chronic cough relief by allosteric modulation of P2X3 without taste disturbance
Nature Communications, 2023 P2X receptors are cation channels that sense extracellular ATP. Many therapeutic candidates targeting P2X receptors have begun clinical trials or acquired approval for the treatment of refractory chronic cough (RCC) and other disorders.
Chang-Run Guo +17 more
doaj +1 more source
Where Eastern Medicine Meets Western Medicine: A World Review of the Management of Chronic Cough
World Journal of Otorhinolaryngology - Head and Neck Surgery, EarlyView.ABSTRACT Purpose To summarize current Western and Eastern approaches to the evaluation and management of chronic cough, with particular emphasis on etiology‐directed therapy, cough hypersensitivity, behavioral interventions, neuromodulators, procedural treatments, and traditional remedies.
Thomas Zheng Jie Teng +5 more
wiley +1 more source
Domains of P2X receptors involved in desensitization [PDF]
Proceedings of the National Academy of Sciences, 1996 ATP-gated ion channels (P2X receptors) are abundantly expressed in both neuronal and nonneuronal tissues, where they can serve as postsynaptic receptors. The response to ATP shows marked desensitization in some tissues but not others.
Werner, Pia +3 more
openaire +2 more sources
Post-translational regulation of P2X receptor channels: modulation by phospholipids
Frontiers in Cellular Neuroscience, 2013 P2X receptor channels mediate fast excitatory signaling by ATP and play major roles in sensory transduction, neuro-immune communication and inflammatory response.
Louis-Philippe eBernier +2 more
doaj +1 more source
The potential for biased signalling in the P2Y receptor family of GPCRs
British Journal of Pharmacology, EarlyView.The purinergic receptor family is primarily activated by nucleotides, and contains members of both the G protein coupled‐receptor (GPCR) superfamily (P1 and P2Y) and ligand‐gated ion channels (P2X). The P2Y receptors are widely expressed in the human body, and given the ubiquitous nature of nucleotides, purinergic signalling is involved with a plethora
Claudia M. Sisk +2 more
wiley +1 more source