Results 71 to 80 of about 689,514 (206)
Purinergic receptor expression in neuronal, bladder smooth muscle and urothelial cells: characterization and inhibition by low molecular weight antagonists [PDF]
, 2009 P2 purinoceptors comprise ionotropic (P2X) and metabotropic (P2Y) receptor families, responsive to nucleotide ligands and diversely distributed on virtually every mammalian cell. Most cells and tissues co-express multiple subtypes of purinoceptor; thus,
Gever, J.L.
core
Platelets, 2022 Platelets express P2X1 receptors and our data also show the expression of P2X7 receptors. We studied the role of both receptors in platelet apoptosis by incubation of PRP with P2X agonists, then centrifuged to remove viable platelets, and analyzed the ...
Joelyn Wong +6 more
doaj +1 more source
Ion Channel Dysfunction and Therapeutic Targeting in Salivary Gland Disorders
Oral Diseases, EarlyView.ABSTRACT Objective Salivary gland hypofunction and xerostomia represent major clinical complications of radiation therapy, autoimmune disorders such as Sjögren's disease, and inherited epithelial ion transport defects. This review integrates current knowledge on ion channel dysfunction as a central mechanistic driver of salivary gland pathology and ...
Tarek Mohamed Abd El‐Aziz +6 more
wiley +1 more source
Evolution of P2X receptors [PDF]
Wiley Interdisciplinary Reviews: Membrane Transport and Signaling, 2012 AbstractPurines appear to be the most primitive and widespread chemical messengers in all kingdoms of the Domain Eucarya. There is evidence for purinergic signaling in plants, invertebrates, and lower vertebrates from protozoa to birds. Much is based on pharmacological studies, but important recent papers have utilized the techniques of molecular ...
Burnstock, G. +1 more
openaire +1 more source
TMEM16A channel signalling microdomains in the regulation of vascular function
The Journal of Physiology, EarlyView.Abstract figure legend Schematic representation of TMEM16A channel signalling microdomains. Calcium influx or calcium release from the endoplasmic/sarcoplasmic reticulum (ER/SR) activates TMEM16A channels through interactions with regulatory proteins in vascular smooth muscle cells or endothelial cells. TMEM16A channel activation drives chloride efflux,
Fênix Araujo, Swapnil K. Sonkusare
wiley +1 more source
Disulfide bond formation in P2X receptors.
, 2013 Disulfide bond formation in P2X receptors.
Jinsong Liu (6516) +6 more
core +1 more source
Cellular Physiology and Biochemistry, 2016 Background/Aims: Published data suggest that purinergic P2X receptors of muscle afferent nerves contribute to the enhanced sympathetic nervous activity (SNA) and blood pressure (BP) responses during static exercise in heart failure (HF).
Jihong Xing, Jianhua Li
doaj +1 more source
The Journal of Physiology, EarlyView.Abstract figure legend We used an intersectional approach with recombinase‐expressing mice and adeno‐associated virus to map and modulate distinct nociceptive afferents in the vagal ganglia. TRPV1+P2X2+ neurons resided in the nodose ganglion (N), innervated the lungs (many projected into the alveoli) but not the trachea, and projected to the nucleus ...
Mayur J. Patil +11 more
wiley +1 more source
The Journal of Physiology, EarlyView.Abstract figure legend The capillary–mitochondria–ion channel (CMIC) axis scales structural resources to match functional workload. (Left) In settings of restricted energetic capacity (e.g. cortical neurons), sparse capillary networks and modest mitochondrial pools set a lower energetic ceiling, sufficient to support phasic, low‐workload excitability. (
L. Fernando Santana, Scott Earley
wiley +1 more source
Slow Neuromodulation Mediated by ATP P2X Receptors [PDF]
, 2014 ATP-gated P2X receptors are widely expressed in the nervous system, but their physiological roles are not fully understood. New insights from Pougnet et al.
Khakh, Baljit S, Xu, Ji
core +1 more source