Results 61 to 70 of about 689,514 (206)
Structural rearrangements and subunit interactions in P2X receptors [PDF]
, 2009 P2X receptors represent the third superfamily of ligand gated ion channels with ATP as their natural ligand. Most of the mammalian P2X receptors are non-selective cation channels, which upon activation, mediate membrane depolarization and have ...
Bhargava, Yogesh, Bhargava, Y.
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P2X receptors in cancer growth and progression
, 2021 It is increasingly appreciated that ion channels have a crucial role in tumors, either as promoters of cancer cell growth, or modulators of immune cell functions, or both.
Sarti A. C. +2 more
core +1 more source
Peripheral targets for neuropathic pain
British Journal of Pharmacology, EarlyView.Neuropathic pain represents a significant clinical challenge, with still limited pharmacological approaches to symptomatic relief. This review focuses on molecular targets implicated in neuropathic pain, particularly those involved in peripheral mechanisms. Using the IUPHAR/BPS database of biological targets, their occurrence together with ‘neuropathic
Amirhossein Afsharipour +3 more
wiley +1 more source
P2X receptors and the endothelium
, 2005 Adenosine triphosphate (ATP) is now established as a principle vaso-active mediator in the vasculature. Its actions on arteries are complex, and are mediated by the P2X and P2Y receptor families.
Harrington, L.S., Mitchell, J.A.
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Principles and properties of ion flow in P2X receptors
Frontiers in Cellular Neuroscience, 2014 P2X receptors are a family of trimeric ion channels that are gated by extracellular adenosine 5’-triphosphate (ATP). These receptors have long been a subject of intense research interest by virtue of their vital role in mediating the rapid and direct ...
Damien Stephen Kenneth Samways +2 more
doaj +1 more source
Purinergic Signaling in Liver Pathophysiology
Frontiers in Endocrinology, 2021 Extracellular nucleosides and nucleotides activate a group of G protein-coupled receptors (GPCRs) known as purinergic receptors, comprising adenosine and P2Y receptors. Furthermore, purinergic P2X ion channels are activated by ATP.
Shanu Jain, Kenneth A. Jacobson
doaj +1 more source
International Endodontic Journal, EarlyView.ABSTRACT Objectives Mechanical and/or microbial stimuli can prompt extracellular ATP release in many cell types, where it acts as an inflammatory mediator to amplify pain signals and inflammation. This study aimed to investigate the synergistic effects of microbial and/or mechanical stimulation on ATP and cytokine release from dental pulp cells (DPCs ...
Orla M. Dunne +4 more
wiley +1 more source
Purinergic receptors in skeletal muscles in health and in muscular dystrophy [PDF]
, 2014 The P2 purinergic (nucleotide) receptor super-family comprises of two families of protein. The P2X, which are channel-forming ionotropic receptors and the P2Y metabotropic receptors activating G protein-mediated signalling pathways.
Young, Christopher +10 more
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Immunology &Cell Biology, EarlyView.Defensins, gasdermins and MLKL are distinct innate immune effectors with membrane disrupting activities that span antimicrobial defence and inflammatory cell death. This review compares the structure and function of these key molecules across four connected processes of (1) protein expression and activation, (2) lipid specific recognition and ...
Serenay B. Demir +3 more
wiley +1 more source
Antipsychotics‐Induced Hyposalivation Mediated by Impaired Salivary Ca2+ Signaling
Oral Diseases, EarlyView.ABSTRACT Objectives Antipsychotic‐induced salivary dysfunction such as hyposalivation is a prevalent clinical challenge that severely compromises oral health and quality of life. Although typical and atypical antipsychotics have their therapeutic target in the central nervous system, their direct molecular mechanisms within the salivary glands remain ...
Chaelin Chung +4 more
wiley +1 more source