Ion permeation pathway within the internal pore of P2X receptor channels [PDF]
eLife, 2023 P2X receptor channels are trimeric ATP-activated ion channels expressed in neuronal and non-neuronal cells that are attractive therapeutic targets for human disorders.
Stephanie W Tam +3 more
doaj +2 more sources
Corneal epithelium expresses a variant of P2X(7) receptor in health and disease. [PDF]
PLoS ONE, 2011 Improper wound repair of the corneal epithelium can alter refraction of light resulting in impaired vision. We have shown that ATP is released after injury, activates purinergic receptor signaling pathways and plays a major role in wound closure. In many
Courtney Mankus +3 more
doaj +2 more sources
The trafficking and targeting of P2X receptors [PDF]
Frontiers in Cellular Neuroscience, 2013 The functional expression of P2X receptors at the plasma membrane is dependent on their trafficking along secretory and endocytic pathways. There are seven P2X receptor subunits, and these differ in their subcellular distributions because they have very ...
Ruth Dorothy Murrell-Lagnado +1 more
doaj +4 more sources
Molecular Mechanisms of P2X Receptor Desensitization [PDF]
Structural DynamicsExtracellular ATP serves as a crucial signaling molecule, present in varying concentrations across diverse cellular environments. The P2X receptor (P2XR) family, which recognizes extracellular ATP, consists of seven subtypes (P2X1R - P2X7R) that form ...
Steven E. Mansoor
doaj +2 more sources
Activity of Peptides Modulating the Action of p2x Receptors: Focus on the p2x7 Receptor [PDF]
PharmaceuticalsP2X receptors are a family of ATP-gated ion channels widely distributed in various tissues, especially in neuronal cells and hematopoietic cells. ATP activates P2X receptors, causing the opening of an ionic channel with preferential permeability to the ...
Jonathas Albertino De Souza Oliveira Carneiro +3 more
doaj +2 more sources
TMEM163 Regulates ATP-Gated P2X Receptor and Behavior [PDF]
Cell Reports, 2020 Miwako Yamasaki +2 more
exaly +2 more sources
Impaired interleukin-1beta and c-Fos expression in the hippocampus is associated with a spatial memory deficit in P2X(7) receptor-deficient mice. [PDF]
PLoS ONE, 2009 Recent evidence suggests that interleukin-1beta (IL-1beta), which was originally identified as a proinflammatory cytokine, is also required in the brain for memory processes.
Virginie F Labrousse +6 more
doaj +1 more source
P2X receptors in neuroglia [PDF]
Wiley Interdisciplinary Reviews: Membrane Transport and Signaling, 2012 AbstractDifferent types of ionotropic P2X purinoceptors are expressed in all major types of neuroglia, where they mediate a variety of physiological and pathological signaling. Cortical astrocytes express specific P2X1/5 heteromeric receptors that are activated by ongoing synaptic transmission and can trigger fast local signaling through elevation in ...
Verkhratsky, A.; id_orcid 0000-0003-2592-9898 +3 more
openaire +3 more sources
P2X4 assembles with P2X7 and pannexin-1 in gingival epithelial cells and modulates ATP-induced reactive oxygen species production and inflammasome activation. [PDF]
PLoS ONE, 2013 We have previously reported that Porphyromonas gingivalis infection of gingival epithelial cells (GEC) requires an exogenous danger signal such as ATP to activate an inflammasome and caspase-1, thereby inducing secretion of interleukin (IL)-1β ...
Shu-Chen Hung +7 more
doaj +1 more source
Direct observation of ATP-induced conformational changes in single P2X(4) receptors. [PDF]
PLoS Biology, 2009 The ATP-gated P2X(4) receptor is a cation channel, which is important in various pathophysiological events. The architecture of the P2X(4) receptor in the activated state and how to change its structure in response to ATP binding are not fully understood.
Youichi Shinozaki +5 more
doaj +1 more source