Results 31 to 40 of about 1,630,443 (126)

Energetic microdomains and the vascular control of neuronal and muscle excitability: Toward a unified model

The Journal of Physiology, EarlyView.
Abstract figure legend The capillary–mitochondria–ion channel (CMIC) axis scales structural resources to match functional workload. (Left) In settings of restricted energetic capacity (e.g. cortical neurons), sparse capillary networks and modest mitochondrial pools set a lower energetic ceiling, sufficient to support phasic, low‐workload excitability. (
L. Fernando Santana, Scott Earley
wiley   +1 more source

Intrinsic pH chemosensitivity of acutely dissociated medullary serotonergic and retrotrapezoid neurones

The Journal of Physiology, EarlyView.
Abstract figure legend Central respiratory chemoreceptors (CRCs) are critical for maintaining normal systemic levels of pH and PCO2. A CRC must respond to pH via intrinsic mechanisms. Here we quantified intrinsic chemosensitivity of medullary 5‐HT neurones and retrotrapezoid nucleus (RTN) neurones using acute dissociation.
Yuanming Wu, Eduardo Bravo, George Bradley Richerson   +2 more
wiley   +1 more source

Ionic selectivity of native ATP-activated (P2X) receptor channels in dissociated neurones from rat parasympathetic ganglia [PDF]

, 2001
1. The relative permeability of the native P2X receptor channel to monovalent and divalent inorganic and organic cations was determined from reversal potential measurements of ATP-evoked currents in parasympathetic neurones dissociated from rat ...
Liu, D. M., Adams, D. J., David J. Adams, Dong‐Mei Liu   +3 more
core   +1 more source

P2X3 receptor antagonism improves hindlimb blood flow during exercise in a conscious ovine model of hypertensive heart failure with preserved ejection fraction

The Journal of Physiology, EarlyView.
Abstract figure legend A preclinical large‐animal model of hypertensive heart failure with preserved ejection fraction (HFpEF) was used to examine the role of purinergic P2X3 receptor signalling during treadmill exercise. Animals were instrumented with either thoracic cardiac output and coronary flow probes or abdominal renal and hindlimb blood flow ...
Mridula Pachen, Siyi Chen, Joshua W.‐H. Chang, Audrys Pauza, Julia Shanks, Bindu George, Julian Paton, Rohit Ramchandra   +7 more
wiley   +1 more source

The P2X receptor mediated regulation of inhibitory synaptic transmission [PDF]

In the central nervous system ATP can be released by neurons and glial cells through similar pathways as other neurotransmitters. Extracellular ATP targets P2X purinoreceptors, causing an influx of Ca2+ ions which transmit very important messages for ...
Andrew-Adiamah, Jemma
core  

Identification of Thr 283 as a key determinant of P2X 7 receptor function [PDF]

, 2006
Background and purpose: The ATP-gated P2X 7 receptor is an unusual ion channel that couples to multiple downstream signalling cascades. We noted differences in mouse cDNA sequences that may indicate polymorphisms; the aim of this study was to compare ...
Young, M. T., P Pelegrin, M T Young, Young, Mark T., Pelegrin, P., Young, Mark, A Surprenant, Young, Mark Thomas, Pelegrin, Pablo, Surprenant, A., Surprenant, Annmarie   +10 more
core   +1 more source

Investigation of the Pathomechanism of Chronic Cough Using an In Vitro Approach

Clinical &Experimental Allergy, Volume 55, Issue 3, Page 247-249, March 2025.
Umesh Singh, Jonathan A. Bernstein
wiley   +1 more source

Electrophysiological properties of the dorsal motor nucleus of the vagus motoneurones controlling airway mucus secretion in rats

The Journal of Physiology, EarlyView.
Abstract figure legend Acidosis depolarises parasympathetic respiratory motoneurones in the dorsal motor nucleus of the vagus (DMV) and increases their firing frequency by reducing TWIK‐2 channel conductance. Acidosis also activates astrocytes, which further enhance neuronal excitability through NMDA receptor‐dependent glutamatergic signalling.
Daniel P. de Souza, Renato W. Martins Sá, Luiza Henrique de Souza, Fernando S. Ramalho, Davi J. A. Moraes   +4 more
wiley   +1 more source

From Mechanical Perturbation to Pathological Locking: Temporal–Mechanical Evolution of the Postsynaptic Density After Traumatic Brain Injury

CNS Neuroscience &Therapeutics, Volume 32, Issue 11, November 2026.
The postsynaptic density (PSD) may convert traumatic mechanical loading into persistent synaptic dysfunction. This review proposes a temporal–mechanical model in which PSD injury progresses from hyperacute mechanical deconstruction (Phase I) through an acute‐to‐subacute metabolic–mechanical crisis (Phase II) to chronic low‐dynamic pathological locking (
Yibin Jia, Zixuan Cao, Hanjiang Xue, Zhebin Feng, Zhiguo Ma, Zhicheng Tian, Xin Li, Peng Luo   +7 more
wiley   +1 more source

Pharmacological investigations on muscarinic and P2 receptor subtypes : pharmacological charakterisation of the stereoisomers of glycopyrronium bromide and their tertiary analogues and evaluation of the isolated guinea-pig and rat ileal longitudinal [PDF]

, 2003
Die Beschäftigung mit Muskarinrezeptoren reicht bis in das vergangene Jahrhundert zurück als, in Folge der verschiedenen Wirkungen des Neurotransmitters Acetylcholin, einerseits Nikotin- und andererseits Muskarinrezeptoren sowie deren Subtypen entdeckt ...
Czeche, Sittah
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