Results 41 to 50 of about 1,630,443 (126)

Dysregulation of the inflammatory response to the parasite, Toxoplasma gondii, in P2X₇ receptor-deficient mice

, 2011
The P2X₇ receptor (P2X₇R) is a two transmembrane receptor that is highly expressed on the surface of immune cells. Loss of function polymorphisms in this receptor have been linked to increased susceptibility to intracellular pathogens.
Boulter, Nicola R., Katrib, M, Smith, Nicholas C. (R18939), Ikin, Rowan J., Katrib, Marilyn, Rowan J. Ikin, Boulter, NR, Ikin, RJ, Nicholas C. Smith, Fuller, SJ, Smith, Nicholas C., Wiley, James S., Nicola R. Boulter, Marilyn Katrib, Alana M. Zakrzewski, James S. Wiley, Lees, MP, Smith, NC, Catherine M. Miller, Zakrzewski, AM, Lees, Michael P., Stephen J. Fuller, Zakrzewski, Alana M., Fuller, Stephen J., Miller, Catherine M., Miller, CM, Michael P. Lees, Wiley, JS   +27 more
core   +1 more source

Enteric Neurons and Glial Cells Are Partially Protected in P2X7 Receptor‐Deficient Mice With Ulcerative Colitis

Neurogastroenterology &Motility, Volume 38, Issue 11, November 2026.
P2X7R knockout mice efficacy. Chronic DSS‐induced colitis decreased the nitrergic and cholinergic neurons, β3‐tubulin–ir neurons, and GFAP‐ir and S100β glial cells in WT/DSS and KO/DSS groups. P2X7R‐ir cells decreased in WT/DSS animals, and NLRP3‐ir cells increased mostly in WT/DSS, indicating inflammasome activation.
Roberta Figueiroa Souza, Marcos Antônio Ferreira Caetano, Caroline Bures De Paulo, Patricia Castelucci   +3 more
wiley   +1 more source

Synthese, Assemblierung und intrazellulärer Transport von Mitgliedern der cys-loop- und P2X-Familie liganden-gesteuerter Ionenkanäle [PDF]

, 2006
The results presented here strongly indicate that ubiquitination of the recombinant human alpha1 GlyR at the plasma membrane of Xenopus oocytes is involved in receptor internalisation and degradation.
Sadtler, Sven
core  

Supporting AI Readiness Through Digital Workflows in Materials Science

Advanced Engineering Materials, Volume 28, Issue 20, 21 October 2026.
Digitalization drives innovation in materials science by connecting data silos and turning heterogeneous processes into reusable research pipelines. Across 13 MaterialDigital projects, digital workflows reveal complementary pathways toward AI‐ready materials research, founded on structured data, persistent artifacts, executable orchestration, and ...
Marian Bruns, Lateef Abdul, Stephan Barth, Martin Glauer, Manuel Günther, Fabian Neuhaus, Jan‐Ole Perschewski, Thomas Bjarsch, Henrik Abel, Johannes Bosch, Niklas Meyer, Peter Hofmann, Marc Drechsler, Alexander Dyck, Dhanunjaya Kumar Nerella, Marvin Tegeler, Oleg Shchyglo, Ingo Steinbach, Timo Klecker, Henk Birkholz, Ehsan Borzabadi Farahani, Bernard Fedelich, Cetin Haftaoglu, Tarakeshwar Lakshmipathy, Elena Garcia Trelles, Christoph Schweizer, Reza Darvishi Kamachali, Lukas Koschmieder, Janin Eiken, Markus Apel, Sung‐Min Wi, Jiangdong Zhao, Andreas Fezer, Nicolas Christ, Patrick Schneider, Eldor Urinov, Veit Königer, Volker Knoblauch, Janik Harter, Thomas Seifert, Thitichai Janpheng, Florian Fuchs, Fabian Teichert, Jörg Schuster, Anke Bardehle, Andreas Limper, Ulrich Giese, Carlos Lucke, Mario Beiner, Christoph Gögelein, Lisa Leuchtenberger‐Engel, Christian Hopmann, Felix Wentzien, Heike Wittek, Benjamin Klie, Alexander Röhrs, Ludger Overmeyer, Achraf Atila, Marcel Sadowski, Leopold Talirz, Jan Janssen, Jesper R. Pedersen, Peter Beck, Tejs Vegge, Ivano E. Castelli, Wolfgang Wenzel, Tilmann Hickel, Jörg Schaarschmidt   +67 more
wiley   +1 more source

Corneal epithelium expresses a variant of P2X(7) receptor in health and disease. [PDF]

, 2011
Improper wound repair of the corneal epithelium can alter refraction of light resulting in impaired vision. We have shown that ATP is released after injury, activates purinergic receptor signaling pathways and plays a major role in wound closure. In many
Courtney Mankus, Celeste Rich, Mankus Courtney, Trinkaus-Randall Vickery, Vickery Trinkaus-Randall, Minns Martin, Martin Minns, Rich Celeste   +7 more
core   +1 more source

Single nucleotide polymorphisms identified in the human P2X₇ receptor.

, 2013
Single nucleotide polymorphisms identified in the human P2X7 receptor.
Alana M. Zakrzewski (339833), Nicholas C. Smith (328727), Nicola R. Boulter (339831), Stephen J. Fuller (339832), Bernadette M. Saunders (163212), James S. Wiley (339835), Catherine M. Miller (339830), Michael P. Lees (339834)   +7 more
core   +1 more source

Ion permeation pathway within the internal pore of P2X receptor channels. [PDF]

Elife, 2023
Tam SW, Huffer K, Li M, Swartz KJ.
europepmc   +1 more source

Variability in P2X receptor composition in human taste nerves: implications for treatment of chronic cough. [PDF]

ERJ Open Res, 2023
High B, Jetté ME, Li M, Ramakrishnan VR, Clary M, Prager J, Draf J, Hummel T, Finger TE.   +8 more
europepmc   +1 more source

Update of P2X receptor properties and their pharmacology: IUPHAR Review 30. [PDF]

Br J Pharmacol, 2021
Illes P, Müller CE, Jacobson KA, Grutter T, Nicke A, Fountain SJ, Kennedy C, Schmalzing G, Jarvis MF, Stojilkovic SS, King BF, Di Virgilio F.   +11 more
europepmc   +1 more source

Detection of P2X purinergic receptors on human B lymphocytes

, 2001
B lymphocytes are known to synthesise the P2X(7) subtype of the P2X purinergic receptor family; however, the identification of the other six P2X subtypes on these cells has been limited by the absence of specific antibodies.
James Wiley (238948), J A Barden (20203539), Ronald Sluyter (19586773)   +2 more
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