Results 81 to 90 of about 689,514 (206)
Manipulation of P2X Receptor Activities by Light Stimulation
Mediators of Inflammation, 2016 P2X receptors are involved in amplification of inflammatory responses in peripheral nociceptive fibers and in mediating pain-related signals to the CNS.
Sang Seong Kim
doaj +1 more source
The Journal of Physiology, EarlyView.Abstract figure legend Central respiratory chemoreceptors (CRCs) are critical for maintaining normal systemic levels of pH and PCO2. A CRC must respond to pH via intrinsic mechanisms. Here we quantified intrinsic chemosensitivity of medullary 5‐HT neurones and retrotrapezoid nucleus (RTN) neurones using acute dissociation.
Yuanming Wu +2 more
wiley +1 more source
Purinergic signalling: past, present and future [PDF]
, 2009 The discovery of non-adrenergic, non-cholinergic neurotransmission in the gut and bladder in the early 1960's is described as well as the identification of adenosine 5'-triphosphate (ATP) as a transmitter in these nerves in the early 1970's.
G. Burnstock, Burnstock, G
core
P2X receptors and acupuncture analgesia
Brain Research Bulletin, 2019 Purinergic signaling has recently been suggested to constitute the cellular mechanism underlying acupuncture-induced analgesia (AA). By extending the original hypothesis on endogenous opioids being released during AA, Geoffrey Burnstock and Maiken Nedergaard supplied evidence for the involvement of purinoceptors (P2 and P1/A1 receptors) in the ...
Yong Tang +4 more
openaire +2 more sources
The Journal of Physiology, EarlyView.Abstract figure legend A preclinical large‐animal model of hypertensive heart failure with preserved ejection fraction (HFpEF) was used to examine the role of purinergic P2X3 receptor signalling during treadmill exercise. Animals were instrumented with either thoracic cardiac output and coronary flow probes or abdominal renal and hindlimb blood flow ...
Mridula Pachen +7 more
wiley +1 more source
Investigation of the Pathomechanism of Chronic Cough Using an In Vitro Approach
Clinical &Experimental Allergy, Volume 55, Issue 3, Page 247-249, March 2025.
Umesh Singh, Jonathan A. Bernstein
wiley +1 more source
The Journal of Physiology, EarlyView.Abstract figure legend Acidosis depolarises parasympathetic respiratory motoneurones in the dorsal motor nucleus of the vagus (DMV) and increases their firing frequency by reducing TWIK‐2 channel conductance. Acidosis also activates astrocytes, which further enhance neuronal excitability through NMDA receptor‐dependent glutamatergic signalling.
Daniel P. de Souza +4 more
wiley +1 more source
A shared mechanism for TNP-ATP recognition by members of the P2X receptor family
Computational and Structural Biotechnology JournalP2X receptors (P2X1–7) are non-selective cation channels involved in many physiological activities such as synaptic transmission, immunological modulation, and cardiovascular function.
Xiao-Bo Ma +11 more
doaj +1 more source
P2X receptors as targets for the treatment of status epilepticus
Frontiers in Cellular Neuroscience, 2013 Prolonged seizures are amongst the most common neurological emergencies. Status epilepticus is a state of continuous seizures that is life-threatening and prompt termination of status epilepticus is critical to protect the brain from permanent damage ...
David C Henshall +7 more
doaj +1 more source
CNS Neuroscience &Therapeutics, Volume 32, Issue 11, November 2026.The postsynaptic density (PSD) may convert traumatic mechanical loading into persistent synaptic dysfunction. This review proposes a temporal–mechanical model in which PSD injury progresses from hyperacute mechanical deconstruction (Phase I) through an acute‐to‐subacute metabolic–mechanical crisis (Phase II) to chronic low‐dynamic pathological locking (
Yibin Jia +7 more
wiley +1 more source