Results 11 to 20 of about 13,556 (211)

The trafficking and targeting of P2X receptors [PDF]

Frontiers in Cellular Neuroscience, 2013
The functional expression of P2X receptors at the plasma membrane is dependent on their trafficking along secretory and endocytic pathways. There are seven P2X receptor subunits, and these differ in their subcellular distributions because they have very ...
Ruth Dorothy Murrell-Lagnado, Lucy Elizabeth Robinson   +1 more
doaj   +5 more sources

P2X receptors and synaptic plasticity

Neuroscience, 2009
Adenosine triphosphate (ATP) is released in many synapses in the CNS either together with other neurotransmitters, such as glutamate and GABA, or on its own.
O A Krishtal
exaly   +4 more sources

P2X receptors in neuroglia [PDF]

Wiley Interdisciplinary Reviews: Membrane Transport and Signaling, 2012
Different types of ionotropic P2X purinoceptors are expressed in all major types of neuroglia, where they mediate a variety of physiological and pathological signaling.
Yuri Pankratov, Pankratov, Y., Lalo, U., Ulyana Lalo, Maiken Nedergaard, Nedergaard, M., Verkhratsky, A.; id_orcid, Alexei Verkhratsky   +7 more
core   +4 more sources

Radioligands Targeting the Purinergic P2X Receptors [PDF]

Cells
Purinergic P2X receptors have a wide distribution within the body and modulate a number of physiological processes, being also involved in the development and progression of inflammation-, neuroinflammation-, neurodegeneration-, and cancer-related ...
Diego Dal Ben, Michela Buccioni, Catia Lambertucci, Beatrice Francucci, Aleksei Smirnov, Andrea Spinaci, Gabriella Marucci, Rosaria Volpini   +7 more
doaj   +2 more sources

Molecular physiology of P2X receptors

Physiological Reviews, 2002
P2X receptors are membrane ion channels that open in response to the binding of extracellular ATP. Seven genes in vertebrates encode P2X receptor subunits, which are 40-50% identical in amino acid sequence.
North, R. Alan
core   +5 more sources

P2X Receptors

, 2018
P2X receptors are ATP-gated ion channels that are ubiquitously expressed in eukaryotic tissues. They are involved in diverse physiological processes, from modulation of synaptic transmission, to inflammation, sensing of taste, bladder filling, and pain ...
Thomas Grutter, Terrance M. Egan, Annette Nicke   +2 more
core   +3 more sources

Signaling at purinergic P2X receptors

Annual Review of Physiology, 2009
P2X receptors are membrane cation channels gated by extracellular ATP. Seven P2X receptor subunits (P2X1-7) are widely distributed in excitable and nonexcitable cells of vertebrates.
Alan North, R., Surprenant, Annmarie
core   +4 more sources

P2X receptors and inflammation

Current Medicinal Chemistry, 2015
Until recently, P2X receptors have not received much attention in the context of immunology and inflammation. While this is justified to a certain extent for P2X1, P2X2, P2X3, P2X5 and P2X6, which still await identification of a convincing role in the ...
DI VIRGILIO, Francesco
core   +4 more sources

P2X receptors. [PDF]

Philos Trans R Soc Lond B Biol Sci, 2016
Extracellular adenosine 5′-triphosphate (ATP) activates cell surface P2X and P2Y receptors. P2X receptors are membrane ion channels preferably permeable to sodium, potassium and calcium that open within milliseconds of the binding of ATP. In molecular architecture, they form a unique structural family.
North RA.
europepmc   +4 more sources

Evolution of P2X receptors [PDF]

Wiley Interdisciplinary Reviews: Membrane Transport and Signaling, 2012
Purines appear to be the most primitive and widespread chemical messengers in all kingdoms of the Domain Eucarya. There is evidence for purinergic signaling in plants, invertebrates, and lower vertebrates from protozoa to birds.
Burnstock, G., Verkhratsky, A.; id_orcid
core   +2 more sources