Results 11 to 20 of about 689,514 (206)
Subunit Arrangement in P2X Receptors [PDF]
The Journal of Neuroscience, 2003 ATP-gated ionotropic receptors (P2X receptors) are distributed widely in the nervous system. For example, a hetero-oligomeric receptor containing both P2X2and P2X3subunits is involved in primary afferent sensation. Each subunit has two membrane-spanning domains.
Jiang, Lin Hua +5 more
core +10 more sources
Philos Trans R Soc Lond B Biol Sci, 2016 Extracellular adenosine 5′-triphosphate (ATP) activates cell surface P2X and P2Y receptors. P2X receptors are membrane ion channels preferably permeable to sodium, potassium and calcium that open within milliseconds of the binding of ATP. In molecular architecture, they form a unique structural family.
North RA.
europepmc +4 more sources
P2X receptors and lipids interact to modulate inflammation [PDF]
Journal of Lipid ResearchP2X receptors are purinergic receptors activated in the presence of extracellular ATP. These receptors are involved in the pathogenesis of various diseases, including inflammatory diseases, and are also associated with pain.
Vitor Nascimento Vidal +4 more
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P2X receptors in neuroglia [PDF]
Wiley Interdisciplinary Reviews: Membrane Transport and Signaling, 2012 AbstractDifferent types of ionotropic P2X purinoceptors are expressed in all major types of neuroglia, where they mediate a variety of physiological and pathological signaling. Cortical astrocytes express specific P2X1/5 heteromeric receptors that are activated by ongoing synaptic transmission and can trigger fast local signaling through elevation in ...
Verkhratsky, A.; id_orcid 0000-0003-2592-9898 +3 more
openaire +4 more sources
P2X Receptors: Potential Therapeutic Targets for Symptoms Associated With Lung Cancer — A Mini Review [PDF]
Frontiers in Oncology, 2021 Symptoms associated with lung cancer mainly consist of cancer-associated pain, cough, fatigue, and dyspnea. However, underlying mechanisms of lung cancer symptom clusters remain unclear.
Yonglin Mai +5 more
doaj +2 more sources
Activated P2X receptors can up-regulate the expressions of inflammation-related genes via NF-κB pathway in spotted sea bass (Lateolabrax maculatus) [PDF]
Frontiers in Immunology, 2023 P2X receptors, including seven subtypes, i.e., P2X1-7, are the ligand-gated ion channels activated by the extracellular ATP playing the critical roles in inflammation and immune response.
Zhaosheng Sun +13 more
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Pharmacology of P2X Receptors and Their Possible Therapeutic Potential in Obesity and Diabetes [PDF]
PharmaceuticalsThe role of P2X ionotropic receptors in the behavior of purinergic signaling on pathophysiological processes has been widely studied. In recent years, the important participation of P2X receptors in physiological and pathological processes, such as ...
Guillermo A. Cabral-García +5 more
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Activity of Peptides Modulating the Action of p2x Receptors: Focus on the p2x7 Receptor [PDF]
PharmaceuticalsP2X receptors are a family of ATP-gated ion channels widely distributed in various tissues, especially in neuronal cells and hematopoietic cells. ATP activates P2X receptors, causing the opening of an ionic channel with preferential permeability to the ...
Jonathas Albertino De Souza Oliveira Carneiro +3 more
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Subtype-Specific Ligand Binding and Activation Gating in Homomeric and Heteromeric P2X Receptors [PDF]
BiomoleculesP2X receptors are ATP-activated, non-specific cation channels involved in sensory signalling, inflammation, and certain forms of pain. Investigations of agonist binding and activation are essential for comprehending the fundamental mechanisms of receptor
Xenia Brünings +4 more
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The trafficking and targeting of P2X receptors [PDF]
Frontiers in Cellular Neuroscience, 2013 The functional expression of P2X receptors at the plasma membrane is dependent on their trafficking along secretory and endocytic pathways. There are seven P2X receptor subunits, and these differ in their subcellular distributions because they have very ...
Ruth Dorothy Murrell-Lagnado +1 more
doaj +4 more sources