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P2X receptors and synaptic plasticity
Neuroscience, 2009 Adenosine triphosphate (ATP) is released in many synapses in the CNS either together with other neurotransmitters, such as glutamate and GABA, or on its own. Postsynaptic action of ATP is mediated through metabotropic P2Y and ionotropic P2X receptors abundantly expressed in neural cells.
Pankratov, Y. +3 more
openaire +3 more sources
Signaling at Purinergic P2X Receptors
Annual Review of Physiology, 2009 P2X receptors are membrane cation channels gated by extracellular ATP. Seven P2X receptor subunits (P2X 1-7 ) are widely distributed in excitable and nonexcitable cells of vertebrates. They play key roles in inter alia afferent signaling (including pain), regulation of renal blood flow ...
Surprenant, Annmarie, Alan North, R.
openaire +4 more sources
The Molecular Determinants of Small-Molecule Ligand Binding at P2X Receptors [PDF]
Frontiers in Pharmacology, 2018 P2X receptors are trimeric eukaryotic ATP-gated cation channels. Extracellular ATP—their physiological ligand—is released as a neurotransmitter and in conditions of cell damage such as inflammation, and substantial evidence implicates P2X receptors in ...
Gaia Pasqualetto +2 more
doaj +2 more sources
Structural insights into the orthosteric inhibition of P2X receptors by non-ATP analog antagonists [PDF]
eLifeP2X receptors are extracellular ATP-gated ion channels that form homo- or heterotrimers and consist of seven subtypes. They are expressed in various tissues, including neuronal and nonneuronal cells, and play critical roles in physiological processes ...
Danqi Sheng +7 more
doaj +2 more sources
P2X receptors as drug targets. [PDF]
Mol Pharmacol, 2013 The study of P2X receptors has long been handicapped by a poverty of small-molecule tools that serve as selective agonists and antagonists. There has been progress, particularly in the past 10 years, as cell-based high-throughput screening methods were applied, together with large chemical libraries.
North RA, Jarvis MF.
europepmc +4 more sources
Modulation of Central Synapses by Astrocyte-Released ATP and Postsynaptic P2X Receptors [PDF]
Neural Plasticity, 2017 Communication between neuronal and glial cells is important for neural plasticity. P2X receptors are ATP-gated cation channels widely expressed in the brain where they mediate action of extracellular ATP released by neurons and/or glia.
Eric Boué-Grabot, Yuriy Pankratov
doaj +2 more sources
Radioligands Targeting the Purinergic P2X Receptors [PDF]
CellsPurinergic P2X receptors have a wide distribution within the body and modulate a number of physiological processes, being also involved in the development and progression of inflammation-, neuroinflammation-, neurodegeneration-, and cancer-related ...
Diego Dal Ben +7 more
doaj +2 more sources
Multiple P2Y receptors couple to calcium-dependent, chloride channels in smooth muscle cells of the rat pulmonary artery [PDF]
, 2005 Uridine 5'-triphosphate (UTP) and uridine 5'-diphosphate (UDP) act via P2Y receptors to evoke contraction of rat pulmonary arteries, whilst adenosine 5'-triphosphate (ATP) acts via P2X and P2Y receptors.
Chootip, Krongkarn +2 more
core +5 more sources
P2X receptors: epithelial ion channels and regulators of salt and water transport. [PDF]
, 2008 When the results from electrophysiological studies of renal epithelial cells are combined with data from in vivo tubule microperfusion experiments and immunohistochemical surveys of the nephron, the accumulated evidence suggests that ATP-gated ion ...
King, Brian F., Wildman, Scott S.P.
core +1 more source
Emerging key roles for P2X receptors in the kidney [PDF]
, 2013 P2X ionotropic non-selective cation channels are expressed throughout the kidney and are activated in a paracrine or autocrine manner following the binding of extracellular ATP and related extracellular nucleotides.
Peppiatt-Wildman, Claire M. +10 more
core +1 more source