Results 31 to 40 of about 51,312 (251)
Extracellular ATP drives systemic inflammation, tissue damage and mortality [PDF]
, 2014 Systemic inflammatory response syndromes (SIRS) may be caused by both infectious and sterile insults, such as trauma, ischemia-reperfusion or burns. They are characterized by early excessive inflammatory cytokine production and the endogenous release of ...
Brouckaert, Peter +4 more
core +1 more source
Chemical Metabolomics: Chemical Biology Tools for Advanced Metabolism Investigations
Angewandte Chemie, EarlyView.The human metabolism has been investigated for several millennia. The metabolome is known for a high complexity due to a large number of different metabolites that are present at different concentrations. Metabolomics has been developed as a field to investigate the entire human metabolome and to elucidate disease development mechanisms.
Alejandro Torregrosa‐Chinillach +4 more
wiley +2 more sources
Purinergic and Adenosinergic Signaling in Pancreatobiliary Diseases
Frontiers in Physiology, 2022 Adenosine 5'-triphosphate (ATP), other nucleotides, and the nucleoside analogue, adenosine, all have the capacity to modulate cellular signaling pathways.
Erika Y. Faraoni +4 more
doaj +1 more source
Role of Pannexin-1 hemichannels and purinergic receptors in the pathogenesis of human diseases
Frontiers in Physiology, 2014 In the last decade several groups have determined the key role of hemichannels formed by pannexins or connexins, extracellular ATP and purinergic receptors in physiological and pathological conditions.
Stephani eVelasquez +3 more
doaj +1 more source
Folia Neuropathologica, 2022 Purinergic signalling is involved in the control of several processes related to brain development, such as neurogenesis and gliogenesis, migration and differentiation of neuronal precursors, synaptogenesis and synaptic elimination to achieve a fully ...
Lidia Babiec +2 more
doaj +1 more source
Purinergic and Calcium Signaling in Macrophage Function and Plasticity
Frontiers in Immunology, 2014 In addition to a fundamental role in cellular bioenergetics, the purine nucleotide adenosine triphosphate (ATP) plays a crucial role in the extracellular space as a signaling molecule.
Bimal N Desai, Norbert eLeitinger
doaj +1 more source
Purinergic Signaling and Related Biomarkers in Depression
Brain Sciences, 2020 It is established that purinergic signaling can shape a wide range of physiological functions, including neurotransmission and neuromodulation. The purinergic system may play a role in the pathophysiology of mood disorders, influencing neurotransmitter ...
Francesco Bartoli +3 more
doaj +1 more source
Purinergic signaling in the modulation of redox biology
Redox Biology, 2021 Purinergic signaling is a cell communication pathway mediated by extracellular nucleotides and nucleosides. Tri- and diphosphonucleotides are released in physiological and pathological circumstances activating purinergic type 2 receptors (P2 receptors ...
Luiz Eduardo Baggio Savio +4 more
doaj +1 more source
Toll-Like Receptor 4 Modulates Small Intestine Neuromuscular Function through Nitrergic and Purinergic Pathways [PDF]
, 2017 Objective: Toll-like receptors (TLRs) play a pivotal role in the homeostatic microflora-host crosstalk. TLR4-mediated modulation of both motility and enteric neuronal survival has been reported mainly for colon with limited information on the role of ...
Cecilia Giulivi +12 more
core +3 more sources
The Role of Microglial Purinergic Receptors in Pain Signaling
Molecules, 2022 Pain is an essential modality of sensation in the body. Purinergic signaling plays an important role in nociceptive pain transmission, under both physiological and pathophysiological conditions, and is important for communication between both neuronal ...
Hidetoshi Tozaki-Saitoh +2 more
doaj +1 more source