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P2Y receptors and kidney function [PDF]
Wiley Interdisciplinary Reviews: Membrane Transport and Signaling, 2012 AbstractCellular release of nucleotides is of physiological importance to regulate and maintain cell function and integrity. Also in the tubular and collecting duct system of the kidney, nucleotides are released in response to changes in cell volume or luminal flow rate and act in a paracrine and autocrine way on basolateral and luminal P2Y receptors ...
Volker, Vallon +2 more
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BMC Immunology, 2004 Background Extracellular nucleotides (ATP, ADP, UTP and UDP) exert a wide range of biological effects in blood cells mediated by multiple ionotropic P2X receptors and G protein-coupled P2Y receptors.
Bengtsson Anders +3 more
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P2Y6 receptor potentiates pro-inflammatory responses in macrophages and exhibits differential roles in atherosclerotic lesion development. [PDF]
PLoS ONE, 2014 BACKGROUND: P2Y(6), a purinergic receptor for UDP, is enriched in atherosclerotic lesions and is implicated in pro-inflammatory responses of key vascular cell types and macrophages. Evidence for its involvement in atherogenesis, however, has been lacking.
Ricardo A Garcia +17 more
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Quantitative Super-Resolution Imaging for the Analysis of GPCR Oligomerization
Biomolecules, 2021 G-protein coupled receptors (GPCRs) are known to form homo- and hetero- oligomers which are considered critical to modulate their function. However, studying the existence and functional implication of these complexes is not straightforward as ...
Megan D. Joseph +4 more
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P2Y receptors and pain transmission [PDF]
Purinergic Signalling, 2004 It is widely accepted that the most important ATP receptors involved in pain transmission belong to the P2X(3) and P2X(2/3) subtypes, selectively expressed in small diameter dorsal root ganglion (DRG) neurons. However, several types of the metabotropic ATP (P2Y) receptors have also been found in primary afferent neurons; P2Y(1) and P2Y(2) receptors are
Gerevich, Zoltan, Illes, Peter
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Molecular Pain, 2014 Background: The participation of spinal P2X receptors in neuropathic pain is well recognized. However, the role of P2Y receptors has been less studied. The purpose of this study was to investigate the contribution of spinal P2Y 6,11 receptors following ...
Paulino Barragán-Iglesias +6 more
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Frontiers in Pharmacology, 2023 The P2Y receptors are responsible for the regulation of various physiological processes including neurotransmission and inflammatory responses. These receptors are also considered as novel potential therapeutic targets for prevention and treatment of ...
Sehrish Bano +6 more
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BMC Neuroscience, 2007 Background Adrenal chromaffin cells mediate acute responses to stress through the release of epinephrine. Chromaffin cell function is regulated by several receptors, present both in adrenergic (AD) and noradrenergic (NA) cells.
Castro Enrique +3 more
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P2X1 receptors and the endothelium
Memorias do Instituto Oswaldo Cruz, 2005 Adenosine triphosphate (ATP) is now established as a principle vaso-active mediator in the vasculature. Its actions on arteries are complex, and are mediated by the P2X and P2Y receptor families.
LS Harrington, JA Mitchell
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Stabilizing role of platelet P2Y(12) receptors in shear-dependent thrombus formation on ruptured plaques. [PDF]
PLoS ONE, 2010 BACKGROUND: In most models of experimental thrombosis, healthy blood vessels are damaged. This results in the formation of a platelet thrombus that is stabilized by ADP signaling via P2Y(12) receptors.
Reyhan Nergiz-Unal +8 more
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