Results 21 to 30 of about 688,584 (205)
In Silico Drug Design for Purinergic GPCRs: Overview on Molecular Dynamics Applied to Adenosine and P2Y Receptors [PDF]
Biomolecules, 2020 Molecular modeling has contributed to drug discovery for purinergic GPCRs, including adenosine receptors (ARs) and P2Y receptors (P2YRs). Experimental structures and homology modeling have proven to be useful in understanding and predicting structure ...
Veronica Salmaso, Kenneth A. Jacobson
doaj +2 more sources
ATP Release and Purinergic Signaling Potentiate β-Adrenergic Effects on Brown Adipocytes. [PDF]
Acta Physiol (Oxf)ABSTRACT Aim Brown adipose tissue (BAT) specializes in energy consumption and thermogenesis in response to cold stress. Brown adipocytes (BA) express purinergic receptors, yet little is known about the source of extracellular ATP and the role of purinergic signaling, and the potential interaction with β‐adrenergic signaling.
Tozzi M +8 more
europepmc +2 more sources
Immunolocalisation of P2Y receptors in the rat eye [PDF]
Purinergic Signalling, 2004 Nucleotides present an important role in ocular physiology which has been demonstrated by recent works that indicate their involvement in many ocular processes. P2Y are important among P2 receptors since they can control tear production, corneal wound healing, aqueous humour dynamics and retinal physiology.
Pintor Just, Jesús Jerónimo +5 more
openaire +5 more sources
P2Y Receptors in Synaptic Transmission and Plasticity: Therapeutic Potential in Cognitive Dysfunction [PDF]
Neural Plasticity, 2016 ATP released from neurons and astrocytes during neuronal activity or under pathophysiological circumstances is able to influence information flow in neuronal circuits by activation of ionotropic P2X and metabotropic P2Y receptors and subsequent ...
Segundo J. Guzman, Zoltan Gerevich
doaj +2 more sources
Pharmacological and Molecular Characterisation of P2Y Receptors in Endothelial and Epithelial Cells [PDF]
, 2007 Submitted in partial fulfilment of the requirements of the University of Wolverhampton for the degree of Doctor of PhilosophyIn light of the significant modulation of receptor activity previously shown by a peptide (designated L247), designed to mimic ...
D’Souza, Vijay Kenneth
core +3 more sources
Biomolecules, 2021 Nucleotides released by smooth muscle cells (SMCs) and by innervating nerve terminals activate specific P2 receptors and modulate bladder contraction. We hypothesized that cell surface enzymes regulate SMC contraction in mice bladder by controlling the ...
Romuald Brice Babou Kammoe +4 more
doaj +1 more source
Update of P2Y receptor pharmacology : IUPHAR Review 27 [PDF]
, 2020 Eight G protein-coupled P2Y receptor subtypes respond to extracellular adenine and uracil mononucleotides and dinucleotides. P2Y receptors belong to the δ group of rhodopsin-like GPCRs and contain two structurally distinct subfamilies: P2Y 1, P2Y 2, P2Y ...
Miras-Portugal, M. Teresa +33 more
core +3 more sources
Pharmaceuticals, 2023 Purine nucleosides (adenosine) and nucleotides such as adenosine mono/di/triphosphate (AMP/ADP/ATP) may produce complex cardiovascular responses. For example, adenosine-5′-(β-thio)-diphosphate (ADPβS; a stable synthetic analogue of ADP) can induce ...
Roberto C. Silva-Velasco +4 more
doaj +1 more source
Life, 2021 Extracellular ATP in the tumor microenvironment exhibits either pro- or antitumor effect via interaction with P2Y receptors, but the intracellular signaling and functional roles of P2Y receptors in oral squamous cell carcinoma (OSCC) are unclear.
Chia Chih Lau +5 more
doaj +1 more source
Molecules, 2022 Extracellular ATP exerts important functions as an extracellular signaling molecule via the activation of specific P2 purinergic receptors (P2X and P2Y).
Marco Rossato +9 more
doaj +1 more source