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Control of Macrophage Inflammation by P2Y Purinergic Receptors [PDF]
Cells, 2021 Macrophages comprise a phenotypically and functionally diverse group of hematopoietic cells. Versatile macrophage subsets engage to ensure maintenance of tissue integrity.
Dominik Klaver +2 more
exaly +5 more sources
P2Y Purinergic Receptors, Endothelial Dysfunction, and Cardiovascular Diseases [PDF]
International Journal of Molecular Sciences, 2020 Purinergic G-protein-coupled receptors are ancient and the most abundant group of G-protein-coupled receptors (GPCRs). The wide distribution of purinergic receptors in the cardiovascular system, together with the expression of multiple receptor subtypes ...
Alexander D Verin +2 more
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Distribution of P2Y and P2X purinergic receptor expression within the intestine
American Journal of Physiology - Renal PhysiologyNucleotides are potent extracellular signaling molecules during homeostasis, infection, and injury due to their ability to activate purinergic receptors.
Kristen A Engevik +2 more
exaly +4 more sources
Changes in P2Y Purinergic Receptor Expression in the Ciliary Body in a Murine Model of Glaucoma [PDF]
Frontiers in Pharmacology, 2017 Glaucoma is a neuropathology, often accompanied by an elevated intraocular pressure (IOP), which can lead to blindness. Since DBA/2J mice develop glaucoma, several studies of the physiopathology of glaucoma have been reported in this animal model.
Pérez de Lara, María Jesús +5 more
core +6 more sources
Computational and Structural Biotechnology Journal, 2023 Purinergic receptors are membrane proteins that regulate numerous cellular functions by catalyzing reactions involving purine nucleotides or nucleosides.
Ri Han, Jiho Yoo, Yoonji Lee
exaly +2 more sources
Heterogeneity of P2u- and P2y-purinergic receptor regulation of phospholipases in MDCK cells
American Journal of Physiology-Renal Physiology, 1996 We have characterized the signaling pathways of purinergic receptors present on the renal epithelial cell line, Madin-Darby canine kidney (MDCK, D1 subclone).
M. Xing +4 more
core +3 more sources
P2Y purinergic receptors: New targets for analgesic and antimigraine drugs [PDF]
Biochemical Pharmacology, 2013 Millions of individuals worldwide suffer from acute and, more severely, chronic pain conditions (e.g., neuropathic pain, and migraine). The latter bear tremendous personal, familial, and social costs, since sufferers and their relatives undergo a complete turnaround of their lives with the search of relief from pain becoming their pivotal thought ...
G. Magni, S.M. Ceruti
openaire +3 more sources
Identification of a P2Y-purinergic receptor that inhibits adenylyl cyclase.
The Journal of Pharmacology and Experimental Therapeutics, 1993 Adenine nucleotides inhibited isoproterenol- and forskolin-stimulated cyclic AMP accumulation in C6-2B rat glioma cells. Inhibition occurred in the presence of a phosphodiesterase inhibitor, and no effect of adenine nucleotides was observed in direct measurements of phosphodiesterase activity in intact cells.
J L, Boyer +3 more
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Multiple P2Y receptors couple to calcium-dependent, chloride channels in smooth muscle cells of the rat pulmonary artery [PDF]
, 2005 Uridine 5'-triphosphate (UTP) and uridine 5'-diphosphate (UDP) act via P2Y receptors to evoke contraction of rat pulmonary arteries, whilst adenosine 5'-triphosphate (ATP) acts via P2X and P2Y receptors.
Chootip, Krongkarn +9 more
core +1 more source
Using antibodies against P2Y and P2X receptors in purinergic signaling research [PDF]
Purinergic Signalling, 2011 The broad expression pattern of the G protein-coupled P2Y receptors has demonstrated that these receptors are fundamental determinants in many physiological responses, including neuromodulation, vasodilation, inflammation, and cell migration. P2Y receptors couple either G(q) or G(i) upon activation, thereby activating different signaling pathways ...
Brass, Dovrat +4 more
openaire +2 more sources