Results 21 to 30 of about 8,875 (174)

Purinergic P2Y receptors: Molecular diversity and implications for treatment of cardiovascular diseases

Pharmacology & Therapeutics, 2017
Purinergic signaling, mediated mainly by G protein-coupled P2Y receptors (P2YRs), is now attracting attention as a new therapeutic target for preventing or treating cardiovascular diseases. Observations using mice with genetically modified P2YRs and/or treated with a pharmacological P2YR inhibitor have helped us understand the physiological and ...
Akiyuki, Nishimura, Caroline, Sunggip, Sayaka, Oda, Takuro, Numaga-Tomita, Makoto, Tsuda, Motohiro, Nishida   +5 more
openaire   +2 more sources

Cloning of a Human Purinergic P2Y Receptor Coupled to Phospholipase C and Adenylyl Cyclase [PDF]

Journal of Biological Chemistry, 1997
Clones encoding a new human P2Y receptor, provisionally called P2Y11, have been isolated from human placenta complementary DNA and genomic DNA libraries. The 1113-base pair open reading frame is interrupted by one intron. The P2Y11 receptor is characterized by considerably larger second and third extracellular loops than the subtypes described so far ...
Communi, Didier, Govaerts, Cédric, Parmentier, Marc, Boeynaems, Jean-Marie   +3 more
openaire   +3 more sources

P2Y purinergic receptor regulation of CFTR chloride channels in mouse cardiac myocytes [PDF]

The Journal of Physiology, 2004
The intracellular signalling pathways and molecular mechanisms responsible for P2‐purinoceptor‐mediated chloride (Cl−) currents (ICl,ATP) were studied in mouse ventricular myocytes. In standard NaCl‐containing extracellular solutions, extracellular ATP (100 μm) activated two different currents, ICl,ATP with a linear I–V relationship in symmetrical Cl ...
Shintaro, Yamamoto-Mizuma, Ge-Xin, Wang, Joseph R, Hume   +2 more
openaire   +2 more sources

Novel Organelle‐Based Intracellular Immunity With Mechanistic and Therapeutic Implications

Barrier Immunity, EarlyView.
A conceptual framework illustrating how PAMPs/DAMPs initiate barrier, innate, adaptive, and intracellular immune responses, with organelle‐based intracellular immunity serving as a central integrator linking metabolism, inflammatory signaling, and therapeutic interventions to restore immune homeostasis.
Keman Xu, Shih‐Yu Hung, Fatma Saaoud, Ying Shao, Yifan Lu, Juanjuan Liu, Bo Yuan, Haiyan Xiang, Hong Wang, Xiaofeng Yang   +9 more
wiley   +1 more source

Pharmacological and Molecular Characterisation of P2Y Receptors in Endothelial and Epithelial Cells [PDF]

, 2007
Submitted in partial fulfilment of the requirements of the University of Wolverhampton for the degree of Doctor of PhilosophyIn light of the significant modulation of receptor activity previously shown by a peptide (designated L247), designed to mimic ...
D’Souza, Vijay Kenneth
core  

A New Vista of Opportunity in Diabetes Management: Natural Product‐Based β‐cell Preservation

Food Chemistry International, EarlyView.
Preserving functional β‐cells via natural products offers promising strategy for diabetes treatment. ABSTRACT A defining characteristic of diabetes is β‐cell failure, in which β‐cells cannot modulate insulin secretion to compensate for escalating insulin resistance, pushing forward disease development.
Yi‐San Lee, Tien‐Fen Kuo, Chun‐Yen Yang, Greta Yang, Wen‐Chin Yang   +4 more
wiley   +1 more source

P2X1 and P2X5 subunits form the functional P2X receptor in mouse cortical astrocytes [PDF]

, 2008
ATP plays an important role in signal transduction between neuronal and glial circuits and within glial networks. Here we describe currents activated by ATP in astrocytes acutely isolated from cortical brain slices by non-enzymatic mechanical ...
Lalo, Ulyana, Pankratov, Yuriy, Verkhratsky, A. N. (Alekseĭ Nestorovich), Wichert, S., Kirchhoff, F., Rossner, Moritz J., Verkhratsky, Alexei; id_orcid, Kirchhoff, Frank, Verkhratsky, Alexei, Pankratov, Y., Rossner, M., Lalo, U., Verkhratskiĭ, A. N. (Alekseĭ Nestorovich), North, R., Pankratov, Yuri, North, R. Alan, Verkhratsky, A., Wichert, Sven P.   +17 more
core   +1 more source

Purinergic neurotransmission and nucleotide receptors

, 2023
Adenosine 5′-triphosphate (ATP) is a neurotransmitter of postganglionic sympathetic nerves and nonadrenergic, noncholinergic nerves of the enteric nervous system.
Fountain, Samuel J.
core   +1 more source

The potential for biased signalling in the P2Y receptor family of GPCRs

British Journal of Pharmacology, EarlyView.
The purinergic receptor family is primarily activated by nucleotides, and contains members of both the G protein coupled‐receptor (GPCR) superfamily (P1 and P2Y) and ligand‐gated ion channels (P2X). The P2Y receptors are widely expressed in the human body, and given the ubiquitous nature of nucleotides, purinergic signalling is involved with a plethora
Claudia M. Sisk, Simon Pitchford, Graham Ladds   +2 more
wiley   +1 more source

ATP induces contraction of cultured brain capillary pericytes, via activation of P2Y type purinergic receptors

, 2021
Brain capillary pericytes have been suggested to play a role in the regulation of cerebral blood-flow under physiological and pathophysiological conditions.
Lauritzen, Martin, Brodin, Birger, Helms, Hans C, Cai, Changsi, Hørlyck, Sofie   +4 more
core   +1 more source