Results 21 to 30 of about 156,709 (208)

Exploring Adenosine Receptor Ligands: Potential Role in the Treatment of Cardiovascular Diseases

Molecules, 2017
Cardiovascular diseases remain the number one diseases affecting patients’ morbidity and mortality. The adenosine receptors are G-protein coupled receptors which have been of interest for drugs target for the treatment of multiple diseases ranging from ...
Werner J. Geldenhuys, Ahmad Hanif, June Yun, Mohammed A. Nayeem   +3 more
doaj   +1 more source

The dynamics of single spike-evoked adenosine release in the cerebellum [PDF]

, 2011
The purine adenosine is a potent neuromodulator in the brain, with roles in a number of diverse physiological and pathological processes. Modulators such as adenosine are difficult to study as once released they have a diffuse action (which can affect ...
Boris P. Klyuch, Mark J. Wall, Richardson, Magnus J. E., Klyuch, Boris P., Dale, Nicholas, Magnus J. E. Richardson, Wall, Mark J., Nicholas Dale   +7 more
core   +1 more source

Diabetes downregulates renal adenosine A2A receptors in an experimental model of hypertension.

PLoS ONE, 2019
Studies on diabetic nephropathy rarely take into account that the co-existence of diabetes and hypertension is frequent and further aggravates the prognosis of renal dysfunction.
Daniela Patinha, Carla Carvalho, Carla Abreu, Olga M Cunha, Mariana C Mota, Joana Afonso, António Albino-Teixeira, Carmen Diniz, Manuela Morato   +8 more
doaj   +1 more source

Impaired Inhibitory Function of Presynaptic A1-Adenosine Receptors in SHR Mesenteric Arteries

Journal of Pharmacological Sciences, 2013
In hypertension, vascular reactivity alterations have been attributed to numerous factors, including higher sympathetic innervation/adenosine. This study examined the modulation of adenosine receptors on vascular sympathetic nerves and their putative ...
Carolina Rocha-Pereira, Silvia Magdalena Arribas, Paula Fresco, Maria Carmen González, Jorge Gonçalves, Carmen Diniz   +5 more
doaj   +1 more source

Adenosine Receptors and Asthma [PDF]

, 2009
The pathophysiological processes underlying respiratory diseases like asthma are complex, resulting in an overwhelming choice of potential targets for the novel treatment of this disease. Despite this complexity, asthmatic subjects are uniquely sensitive to a range of substances like adenosine, thought to act indirectly to evoke changes in respiratory ...
Constance N, Wilson, Ahmed, Nadeem, Domenico, Spina, Rachel, Brown, Clive P, Page, S Jamal, Mustafa   +5 more
openaire   +2 more sources

Wakefulness affects synaptic and network activity by increasing extracellular astrocyte-derived adenosine [PDF]

, 2012
Loss of sleep causes an increase in sleep drive and deficits in hippocampal-dependent memory. Both of these responses are thought to require activation of adenosine A1 receptors (adorA1Rs) and release of transmitter molecules including ATP, which is ...
Schmitt, L. Ian, R. E. Sims, Sims, Robert E., P. G. Haydon, Dale, Nicholas, Sims, Robert, Haydon, Philip G, L. I. Schmitt, N. Dale, Schmitt, L Ian   +9 more
core   +1 more source

Purine and purinergic receptors

Brain and Neuroscience Advances, 2018
Adenosine 5′-triphosphate acts as an extracellular signalling molecule (purinergic signalling), as well as an intracellular energy source. Adenosine 5′-triphosphate receptors have been cloned and characterised. P1 receptors are selective for adenosine, a
Geoffrey Burnstock
doaj   +1 more source

Allosteric Modulators of Adenosine Receptors

, 2023
Allosterism occurs when a ligand binds to a receptor on a binding site distinct from the orthosteric one to which endogenous ligand normally binds. Among the G protein-coupled receptors (GPCRs), the adenosine receptors (ARs), classified as A1, A2A, A2B ...
Da Settimo, Federico, Martini, Claudia, Barresi, Elisabetta, Giacomelli, Chiara, Trincavelli, Maria Letizia, Taliani, Sabrina   +5 more
core   +1 more source

Adenosine A2A Receptor Modulates the Activity of Globus Pallidus Neurons in Rats

Frontiers in Physiology, 2017
The globus pallidus is a central nucleus in the basal ganglia motor control circuit. Morphological studies have revealed the expression of adenosine A2A receptors in the globus pallidus.
Hui-Ling Diao, Hui-Ling Diao, Yan Xue, Xiao-Hua Han, Shuang-Yan Wang, Shuang-Yan Wang, Cui Liu, Wen-Fang Chen, Lei Chen   +8 more
doaj   +1 more source

Activity-dependent release of Adenosine: a critical re-evaluation of mechanism [PDF]

, 2008
Adenosine is perhaps the most important and universal modulator in the brain. The current consensus is that it is primarily produced in the extracellular space from the breakdown of previously released ATP.
Dale, Nicholas, Wall, Mark J.
core   +1 more source