Results 21 to 30 of about 271,223 (294)

Glutamate-induced depression of EPSP–spike coupling in rat hippocampal CA1 neurons and modulation by adenosine receptors [PDF]

, 2010
The presence of high concentrations of glutamate in the extracellular fluid following brain trauma or ischaemia may contribute substantially to subsequent impairments of neuronal function.
Alici, Andersen, Baratte, Bazhenov, Behan, Benveniste, Bernard, Bernard, Brunedge, Canhão, Carlier, Cash, Clement, Connick, Costenla, Coulter, Cunha, Cunha, Cunha, Cunha, Dahl, Daoudal, Davies, de Mendonça, de Mendonça, de Mendonça, Englund, Ferguson, Fontinha, Forghani, Frenguelli, Frenguelli, Fujii, Fujii, Greiner, Heurteaux, Hoehn, Hülsmann, Jester, Jones, Kitagawa, Klishin, Kukley, Latini, Latini, Lau, Lee, Limbrick, Liu, Lopes, Macgregor, Manzoni, Moore, Nikbakht, Nishizawa, O’Kane, O’Kane, Pedata, Perez-Pinzon, Pugliese, Pugliese, Ribeiro, Schubert, Schurr, Sebastião, Sebastião, Sekino, Sperlagh, Stone, Stone, Szatkowski, Taube, Vizi, Von Lubitz, Wall, Wallis, Wirkner, Wirkner   +77 more
core   +1 more source

Purinergic Signaling in the Regulation of Gout Flare and Resolution

Frontiers in Immunology, 2021
Gout flares require monosodium urate (MSU) to activate the NLRP3 inflammasome and secrete sufficient IL-1β. However, MSU alone is not sufficient to cause a flare. This is supported by the evidence that most patients with hyperuricemia do not develop gout
Xiaoling Li, Jie Gao, Jinhui Tao
doaj   +1 more source

Adenosine A2A receptors: localization and function [PDF]

, 2015
Adenosine is an endogenous purine nucleoside present in all mammalian tissues, that originates from the breakdown of ATP. By binding to its four receptor subtypes (A1, A2A, A2B, and A3), adenosine regulates several important physiological functions at ...
A Brand, A Gharib, A Kalhan, A Montinaro, A Mori, A Nishi, A Pinna, A Santos-Rodrigues Dos, A Sato, A Tomaru, AA Link, AE King, AK Dixon, AM Mott, AM Sebastiao, AM Sebastiao, AS Awad, B Sperlagh, B Sperlagh, B Sperlagh, BB Fredholm, BB Fredholm, BB Fredholm, BB Fredholm, BB Fredholm, BB Fredholm, BD Hettinger, C Hammarberg, C Ledent, C Quiroz, C Salgado Garcia, CD Bonan, CM Anderson, CN Wilson, CP Sevigny, D Boison, D Boison, D Boison, D Joel, DC Cassada, DJ Brooks, DJ LaPar, DK Glover, DL Rosin, DL Rosin, DN Bowser, E Dare, E Mazzon, F Ciruela, F Ciruela, F Squadrito, FE Parkinson, G Burnstock, G Burnstock, G Burnstock, G Ghimire, G Haskó, G Schulte, G Schulte, GA Higgins, GE Garcia, GG Yegutkin, GM Halliday, GW Sullivan, H Kobayashi, H Zimmermann, HJ Groenewegen, I Feoktistov, J Espinosa, J Fastbom, J Kang, J Snel, J Tchekalarova, JA Ribeiro, JF Chen, JF Chen, JG Dobson Jr, JM Dickenson, JP Headrick, JR Fozard, JS Fink, K Biber, K Fuxe, K Yamada, KD Pierce, L Antonioli, L Antonioli, L Antonioli, L Belardinelli, L Wells, LC Rump, LP Shearman, M Canals, M Fornai, M Katebi, M Kawamura Jr, M Kurokawa, M Kurokawa, M Lazarus, M Matos, M Matos, M Milanese, M Morelli, M Morelli, M Odashima, M O’Neill, M Pouliot, M Reddington, M Schindler, M Storr, MA Ruiz, MA Schwarzschild, MA Souza, MA Trevethick, MC Wittendorp, MD Desrosiers, MD Okusa, MF Jarvis, MJ Bours, MJ Hussey, MJ Wall, MP Abbracchio, MP Abbracchio, MS Hershfield, N Ates, N Cabello, N Levens, N Rebola, N Rebola, N Simola, O Bonneau, O Cauli, O Pascual, P Carriba, P Carriba, P Popoli, P Popoli, P Svenningsson, P Svenningsson, P Svenningsson, P Svenningsson, P Voorn, PA LeWitt, PJ Gebicke-Haerter, R Rahimian, RA Cunha, RA Cunha, RA Cunha, RD Prediger, RH Al-Mashhadi, RJ Rodrigues, S Ferre, S Ferré, S Ferré, S Ferré, S Ferré, S James, S Latini, S Latini, S Revan, SA Baldwin, SA Hunsucker, SA Rivkees, SA Rivkees, SG Khasar, SJ Augood, SJ Brown, SM Duffy, SN Schiffmann, SN Schiffmann, SP Alexander, SW Schoen, T Eckle, T Kadowaki Horita, T Ochiishi, T Othman, TC Bingham, TF Wang, TH Adair, TV Dunwiddie, TV Dunwiddie, V Ralevic, W Hauber, Y Mizuno, Y Pankratov, Y Pankratov, Y Zhong, Z Díaz-Cabiale, Z Justinova, Z Kovacs, Z Selmeczy   +190 more
core   +1 more source

Exploring Adenosine Receptor Ligands: Potential Role in the Treatment of Cardiovascular Diseases

Molecules, 2017
Cardiovascular diseases remain the number one diseases affecting patients’ morbidity and mortality. The adenosine receptors are G-protein coupled receptors which have been of interest for drugs target for the treatment of multiple diseases ranging from ...
Werner J. Geldenhuys, Ahmad Hanif, June Yun, Mohammed A. Nayeem   +3 more
doaj   +1 more source

A depletable pool of adenosine in area CA1 of the rat hippocampus [PDF]

, 2001
Adenosine plays a major modulatory and neuroprotective role in the mammalian CNS. During cerebral metabolic stress, such as hypoxia or ischemia, the increase in extracellular adenosine inhibits excitatory synaptic transmission onto vulnerable neurons via
Caldwell, Darren, Dale, Nicholas, Frenguelli, Bruno G., Nuritova, Feruza, Pearson, Tim   +4 more
core   +1 more source

Diabetes downregulates renal adenosine A2A receptors in an experimental model of hypertension.

PLoS ONE, 2019
Studies on diabetic nephropathy rarely take into account that the co-existence of diabetes and hypertension is frequent and further aggravates the prognosis of renal dysfunction.
Daniela Patinha, Carla Carvalho, Carla Abreu, Olga M Cunha, Mariana C Mota, Joana Afonso, António Albino-Teixeira, Carmen Diniz, Manuela Morato   +8 more
doaj   +1 more source

Impaired Inhibitory Function of Presynaptic A1-Adenosine Receptors in SHR Mesenteric Arteries

Journal of Pharmacological Sciences, 2013
In hypertension, vascular reactivity alterations have been attributed to numerous factors, including higher sympathetic innervation/adenosine. This study examined the modulation of adenosine receptors on vascular sympathetic nerves and their putative ...
Carolina Rocha-Pereira, Silvia Magdalena Arribas, Paula Fresco, Maria Carmen González, Jorge Gonçalves, Carmen Diniz   +5 more
doaj   +1 more source

Stimulation of endothelial adenosine Al receptors enhances adhesion of neutrophils in the intact guinea pig coronary system [PDF]

, 1994
Objective: The primary aim was to determine the action of pathophysiologically relevant adenosine concentrations (0.1-1 μM) on adhesion of neutrophils to coronary endothelium.
Becker, Bernhard F., Gerlach, E., Raschke, P., Zahler, Stefan   +3 more
core   +1 more source

Adenosine Receptors and Cancer [PDF]

, 2009
The A(1), A(2A), A(2B) and A(3) G-protein-coupled cell surface adenosine receptors (ARs) are found to be upregulated in various tumor cells. Activation of the receptors by specific ligands, agonists or antagonists, modulates tumor growth via a range of signaling pathways.
Fishman P, Bar Yehuda S, Synowitz M, Powell JD, Klotz KN, GESSI, Stefania, BOREA, Pier Andrea   +6 more
openaire   +2 more sources

Adenosine A(2A) and A(2B) Receptors Differentially Modulate Keratinocyte Proliferation: Possible Deregulation in Psoriatic Epidermis [PDF]

, 2017
Adenosine is a potent regulator of inflammation and immunity, but the role of adenosine receptors in keratinocytes remains controversial. We determined that in addition to A2B receptors, human epidermal keratinocytes also express A2A receptors, although ...
Andrés, Rosa M., Arasa, Jorge, Montesinos, María Carmen, Navalón, Pedro, Payá, Miquel, Terencio, María Carmen, Valcuende-Cavero, Francisca   +6 more
core   +1 more source