Results 21 to 30 of about 761,976 (296)
Purinergic Signaling in the Regulation of Gout Flare and Resolution
Frontiers in Immunology, 2021 Gout flares require monosodium urate (MSU) to activate the NLRP3 inflammasome and secrete sufficient IL-1β. However, MSU alone is not sufficient to cause a flare. This is supported by the evidence that most patients with hyperuricemia do not develop gout
Xiaoling Li, Jie Gao, Jinhui Tao
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Exploring Adenosine Receptor Ligands: Potential Role in the Treatment of Cardiovascular Diseases
Molecules, 2017 Cardiovascular diseases remain the number one diseases affecting patients’ morbidity and mortality. The adenosine receptors are G-protein coupled receptors which have been of interest for drugs target for the treatment of multiple diseases ranging from ...
Werner J. Geldenhuys +3 more
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The dynamics of single spike-evoked adenosine release in the cerebellum [PDF]
, 2011 The purine adenosine is a potent neuromodulator in the brain, with roles in a number of diverse physiological and pathological processes. Modulators such as adenosine are difficult to study as once released they have a diffuse action (which can affect ...
Boris P. Klyuch +7 more
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Annual Review of Physiology, 1992 Our knowledge of A1 and A2ARs has grown dramatically since they were first defined by Burnstock. With the recent purification of the A1AR and the cDNA cloning of the A2AR, an even more rapid expansion of information regarding their structure, function, and regulation should now ensue.
M E, Olah, G L, Stiles
openaire +4 more sources
Diabetes downregulates renal adenosine A2A receptors in an experimental model of hypertension.
PLoS ONE, 2019 Studies on diabetic nephropathy rarely take into account that the co-existence of diabetes and hypertension is frequent and further aggravates the prognosis of renal dysfunction.
Daniela Patinha +8 more
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Impaired Inhibitory Function of Presynaptic A1-Adenosine Receptors in SHR Mesenteric Arteries
Journal of Pharmacological Sciences, 2013 In hypertension, vascular reactivity alterations have been attributed to numerous factors, including higher sympathetic innervation/adenosine. This study examined the modulation of adenosine receptors on vascular sympathetic nerves and their putative ...
Carolina Rocha-Pereira +5 more
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Wakefulness affects synaptic and network activity by increasing extracellular astrocyte-derived adenosine [PDF]
, 2012 Loss of sleep causes an increase in sleep drive and deficits in hippocampal-dependent memory. Both of these responses are thought to require activation of adenosine A1 receptors (adorA1Rs) and release of transmitter molecules including ATP, which is ...
Schmitt, L. Ian +9 more
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Purine and purinergic receptors
Brain and Neuroscience Advances, 2018 Adenosine 5′-triphosphate acts as an extracellular signalling molecule (purinergic signalling), as well as an intracellular energy source. Adenosine 5′-triphosphate receptors have been cloned and characterised. P1 receptors are selective for adenosine, a
Geoffrey Burnstock
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Role of cGMP as second messenger of adenosine in the inhibition of renin release [PDF]
, 1988 Adenosine is known to be a potent inhibitor of renin release from the kidneys. The aim of this study was to investigate the transmembrane signalling avenue that the second messenger of adenosine causes inhibition of renal renin release.
Kurtz, Armin +5 more
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Allosteric Modulators of Adenosine Receptors
, 2023 Allosterism occurs when a ligand binds to a receptor on a binding site distinct from the orthosteric one to which endogenous ligand normally binds. Among the G protein-coupled receptors (GPCRs), the adenosine receptors (ARs), classified as A1, A2A, A2B ...
Da Settimo, Federico +5 more
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