Results 41 to 50 of about 271,223 (294)

Presynaptic Purinergic Modulation of the Rat Neuro-Muscular Transmission

Current Issues in Molecular Biology, 2023
ATP, being a well-known universal high-energy compound, plays an important role as a signaling molecule and together with its metabolite adenosine they both attenuate the release of acetylcholine in the neuro-muscular synapse acting through membrane P2 ...
Adel E. Khairullin, Sergey N. Grishin, Ayrat U. Ziganshin   +2 more
doaj   +1 more source

Presynaptic adenosine receptor-mediated regulation of diverse thalamocortical short-term plasticity in the mouse whisker pathway [PDF]

, 2016
Short-term synaptic plasticity (STP) sets the sensitivity of a synapse to incoming activity and determines the temporal patterns that it best transmits.
Abbott, Agmon, Ariel, Armbruster, Baden, Bale, Beck, Beierlein, Blackman, Borgdorff, Boudreau, Branco, Branco, Bruno, Buonomano, Calloway, Carvalho, Castro-Alamancos, Castro-Alamancos, Chabrol, Cheetham, Chung, Covic, Crair, Cruikshank, Crunelli, David, Daw, de Jong, Dudek, Dunwiddie, Díaz-Quesada, Díaz-Quesada, Elmslie, Ermolyuk, Fioravante, Fioravante, Fontanez, Fortune, Francisco J. Martini, Gabernet, Gil, Gil, Giovanni Ferrati, Heiss, Hennig, Higley, Jouhanneau, Kandaswamy, Kerr, Kidd, Körber, Leal, Lee, Lee, Lerma, Lupica, McCormick, McCormick, Miguel Maravall, Mochida, Moore, Mulle, Mulle, Müller, Nicoll, Ollerenshaw, Pfister, Pologruto, Porter, Poulet, Reig, Ribrault, Rose, Scanziani, Shen, Sherman, Sippy, Slézia, Stratford, Sun, Sylwestrak, Urbain, Urbano, Viaene, Welzel, Wilent, Wu, Yang, Zhao, Zucker   +90 more
core   +2 more sources

ATP as a Multi-target Danger Signal in the Brain

Frontiers in Neuroscience, 2015
ATP is released in an activity-dependent manner from different cell types in the brain, fulfilling different roles as a neurotransmitter, neuromodulator, astrocyte-to-neuron communication, propagating astrocytic responses and formatting microglia ...
Ricardo J Rodrigues, Angelo R Tomé, Angelo R Tomé, Rodrigo A Cunha, Rodrigo A Cunha   +4 more
doaj   +1 more source

Adenosine in the Thymus

Frontiers in Pharmacology, 2017
Adenosine is an ancient extracellular signaling molecule that regulates various biological functions via activating four G-protein-coupled receptors, A1, A2A, A2B, and A3 adenosine receptors. As such, several studies have highlighted a role for adenosine
Krisztina Köröskényi, Krisztina Köröskényi, Gergely Joós, Gergely Joós, Zsuzsa Szondy, Zsuzsa Szondy   +5 more
doaj   +1 more source

In Vivo Positron Emission Tomography Imaging of Adenosine A2A Receptors

Frontiers in Pharmacology, 2020
As an invasive nuclear medical imaging technology, positron emission tomography (PET) possess the possibility to imaging the distribution as well as the density of selective receptors via specific PET tracers.
Meng-Juan Sun, Meng-Juan Sun, Fang Liu, Ya-Fei Zhao, Ya-Fei Zhao, Xiao-Ai Wu   +5 more
doaj   +1 more source

New insights into the biological role of mammalian ADARs; the RNA editing proteins [PDF]

, 2015
The ADAR proteins deaminate adenosine to inosine in double-stranded RNA which is one of the most abundant modifications present in mammalian RNA.
Arieti, Fabiana, Gallo, Angela, Keegan, Liam P., Mannion, Niamh, O'Connell, Mary A.   +4 more
core   +2 more sources

Mapping the evolution of mitochondrial complex I through structural variation

FEBS Letters, EarlyView.
Respiratory complex I (CI) is crucial for bioenergetic metabolism in many prokaryotes and eukaryotes. It is composed of a conserved set of core subunits and additional accessory subunits that vary depending on the organism. Here, we categorize CI subunits from available structures to map the evolution of CI across eukaryotes. Respiratory complex I (CI)
Dong‐Woo Shin, Tingting Chen, James A. Letts   +2 more
wiley   +1 more source

Adenosine Signaling in Autoimmune Disorders

Pharmaceuticals, 2020
The molecular components of the purinergic system (i.e., receptors, metabolizing enzymes and membrane transporters) are widely expressed in the cells of the immune system.
Giulia Magni, Stefania Ceruti
doaj   +1 more source

Calcium-independent inhibitory G-protein signaling induces persistent presynaptic muting of hippocampal synapses [PDF]

, 2011
Adaptive forms of synaptic plasticity that reduce excitatory synaptic transmission in response to prolonged increases in neuronal activity may prevent runaway positive feedback in neuronal circuits.
Chang, Chun Yun, Crawford, Devon C, Hyrc, Krzysztof L, Mennerick, Steven   +3 more
core   +2 more sources

Phosphatidylinositol 4‐kinase as a target of pathogens—friend or foe?

FEBS Letters, EarlyView.
This graphical summary illustrates the roles of phosphatidylinositol 4‐kinases (PI4Ks). PI4Ks regulate key cellular processes and can be hijacked by pathogens, such as viruses, bacteria and parasites, to support their intracellular replication. Their dual role as essential host enzymes and pathogen cofactors makes them promising drug targets.
Ana C. Mendes, Guilherme M. Azevedo, Amanda P. Barcellos, Diana Bahia   +3 more
wiley   +1 more source