Results 51 to 60 of about 803,750 (296)
FEBS Letters, EarlyView.Vacuolar H+‐ATPase (V‐ATPase) is a multisubunit rotary proton pump that acidifies intracellular compartments. Using elastic network models, we identified conserved hinge residues that govern its large‐scale functional motions. We show that intrinsically encoded ‘soft modes’ drive critical functional transitions, including rotary catalysis and ...
Diksha Parwana +3 more
wiley +1 more source
A metabolic immune checkpoint: adenosine in tumor microenvironment
Frontiers in Immunology, 2016 Within tumors, some areas are less oxygenated than others. Since their home ground is under chronic hypoxia, tumor cells adapt to this condition by activating aerobic glycolysis; however, this hypoxic environment is very harsh for incoming immune cells ...
Akio eOhta
doaj +1 more source
Adenosine Signaling in Autoimmune Disorders
Pharmaceuticals, 2020 The molecular components of the purinergic system (i.e., receptors, metabolizing enzymes and membrane transporters) are widely expressed in the cells of the immune system.
Giulia Magni, Stefania Ceruti
doaj +1 more source
Presynaptic Purinergic Modulation of the Rat Neuro-Muscular Transmission
Current Issues in Molecular Biology, 2023 ATP, being a well-known universal high-energy compound, plays an important role as a signaling molecule and together with its metabolite adenosine they both attenuate the release of acetylcholine in the neuro-muscular synapse acting through membrane P2 ...
Adel E. Khairullin +2 more
doaj +1 more source
Chemical Probes for the Adenosine Receptors [PDF]
Pharmaceuticals, 2019 Research on the adenosine receptors has been supported by the continuous discovery of new chemical probes characterized by more and more affinity and selectivity for the single adenosine receptor subtypes (A1, A2A, A2B and A3 adenosine receptors). Furthermore, the development of new techniques for the detection of G protein-coupled receptors (GPCR ...
Federico S., Lassiani L., Spalluto G.
openaire +3 more sources
The role of the large conductance Ca2+-activated K+ channel in adenosine receptor-mediated cytoprotection [PDF]
, 2009 The rat embryonic cardiomyoblast-derived H9c2 cell line is increasingly used for studies into cardioprotection, as these cells display similar properties to primary cardiomyocytes.
Fretwell, Laurice V, Fretwell, LV
core
Molecular Oncology, EarlyView.This study identifies somatostatin receptor 4 (Sstr4) as a critical tumor suppressor against skin and head/neck cancers (HNSCC, cSCC, and BCC). The loss of Sstr4 removes a check on cell growth, causing hyperactivation of the MAPK‐ERK signaling pathway (↑).
Ali Taqvi +6 more
wiley +1 more source
Adenosine regulation of the immune system
, 2018 Adenosine is an endogenous nucleoside, released into the extracellular space in response to metabolic stress and cell damage and critically involved in the maintenance of tissue integrity by modulation of the immune system.
Luca Antonioli +7 more
core +1 more source
Intracellular ATP influences synaptic plasticity in area CA1 of rat hippocampus via metabolism to adenosine and activity-dependent activation of adenosine A1 receptors [PDF]
, 2011 The extent to which brain slices reflect the energetic status of the in vivo brain has been a subject of debate. We addressed this issue to investigate the recovery of energetic parameters and adenine nucleotides in rat hippocampal slices and the ...
D. Grahame Hardie +14 more
core +1 more source
Molecular Oncology, EarlyView.Partial inhibition of focal adhesion kinase (FAK) can paradoxically promote tumor growth, rather than simply producing a weaker antitumor effect than that observed with strong FAK suppression. In breast cancer and melanoma models, targeting p110δ PI3K, particularly in macrophages, counteracted these tumor‐promoting effects, highlighting the importance ...
Lydia Xenou +4 more
wiley +1 more source