Results 1 to 10 of about 4,325,962 (256)

Pharmacological targeting of adenosine receptor signaling

Molecular Aspects of Medicine, 2017
Adenosine receptor signaling plays important roles in normal physiology, but is also known to modulate the development or progression of several different diseases. The design of new, efficient, and safe pharmacological approaches to target the adenosine
Luis Sobrevia, Mattias Carlström, Maria Peleli   +2 more
exaly   +2 more sources

Mast cell adenosine receptors function: a focus on the A3 adenosine receptor and inflammation

Frontiers in Immunology, 2012
Adenosine is a metabolite, which has long been implicated in a variety of inflammatory processes. Inhaled adenosine provokes bronchoconstriction in asthmatics or chronic obstructive pulmonary disease (COPD) patients, but not in non-asthmatics. This hyper
Noam eRudich, Katya eRavid, Ronit eSagi-Eisenberg   +2 more
doaj   +2 more sources

Cancer biology and molecular genetics of A3 adenosine receptor

Oncogene, 2021
A3 adenosine receptor (A3AR) is a cell membrane protein, which has been found to be overexpressed in a large number of cancer types. This receptor plays an important role in cancer by interacting with adenosine.
C. Mazziotta, J. Rotondo, C. Lanzillotti, Giulia Campione, F. Martini, M. Tognon   +5 more
semanticscholar   +1 more source

Adenosine-A2A Receptor Pathway in Cancer Immunotherapy

Frontiers in Immunology, 2022
A2A receptors (A2AR), a typical GPCR with a high affinity for adenosine, was expressed in many immune cells, such as regulatory T cells, cytotoxic T cells, macrophages, etc.
Chang Sun, Bochu Wang, Shilei Hao
semanticscholar   +1 more source

Positive allosteric mechanisms of adenosine A1 receptor-mediated analgesia

Nature, 2021
The adenosine A1 receptor (A1R) is a promising therapeutic target for non-opioid analgesic agents to treat neuropathic pain1,2. However, development of analgesic orthosteric A1R agonists has failed because of a lack of sufficient on-target selectivity as
C. Draper-Joyce, Rebecca F. Bhola, Jinan Wang, Apurba Bhattarai, A. T. Nguyen, India Cowie-Kent, Kelly O’Sullivan, Ling Yeong Chia, Hariprasad Venugopal, C. Valant, D. Thal, D. Wootten, Nicolas Panel, Jens Carlsson, M. Christie, P. White, P. Scammells, Lauren T. May, P. Sexton, R. Danev, Yinglong Miao, A. Glukhova, Wendy L. Imlach, A. Christopoulos   +23 more
semanticscholar   +1 more source

Pharmacology of the Adenosine A3 Receptor in the Vasculature and Essential Hypertension. [PDF]

PLoS ONE, 2016
BACKGROUND:Essential hypertension is considered to be a multifactorial disorder and its aetiology has yet to be clearly identified. As the adenosine receptors have a significant role in mediating vasodilation, alterations in their structures or ...
Ming-Fen Ho, Leanne M Low, Roselyn B Rose'Meyer   +2 more
doaj   +1 more source

CRISPR/Cas9 mediated deletion of the adenosine A2A receptor enhances CAR T cell efficacy

Nature Communications, 2021
Adenosine is an immunosuppressive factor that limits anti-tumor immunity through the suppression of multiple immune subsets including T cells via activation of the adenosine A2A receptor (A2AR). Using both murine and human chimeric antigen receptor (CAR)
Lauren Giuffrida, K. Sek, M. Henderson, Junyun Lai, Amanda X. Y. Chen, D. Meyran, Kirsten L. Todd, Emma V. Petley, Sherly Mardiana, C. Mølck, Gregory D. Stewart, B. Solomon, I. Parish, P. Neeson, S. Harrison, L. Kats, Imran G. House, P. Darcy, P. Beavis   +18 more
semanticscholar   +1 more source

The role of muscarinic receptors in the beneficial effects of adenosine against myocardial reperfusion injury in rats. [PDF]

PLoS ONE, 2011
Adenosine, a catabolite of ATP, displays a wide variety of effects in the heart including regulation of cardiac response to myocardial ischemia and reperfusion injury.
Lei Sun, Dong-Ling Li, Mei Zhao, Xi He, Xiao-Jiang Yu, Yi Miao, Hao Wang, Jun Ren, Wei-Jin Zang   +8 more
doaj   +1 more source

Synthesis of Novel Fluorinated Xanthine Derivatives with High Adenosine A_2B Receptor Binding Affinity

Pharmaceuticals, 2021
The G protein-coupled adenosine A2B receptor is suggested to be involved in various pathological processes accompanied by increased levels of adenosine as found in inflammation, hypoxia, and cancer.
Marcel Lindemann, Sladjana Dukic-Stefanovic, Sonja Hinz, Winnie Deuther-Conrad, Rodrigo Teodoro, Cathleen Juhl, Jörg Steinbach, Peter Brust, Christa E. Müller, Barbara Wenzel   +9 more
doaj   +1 more source

Adenosine stimulates the basolateral 50 pS K+ channel in renal proximal tubule via adenosine-A1 receptor

Frontiers in Physiology, 2023
Background: The basolateral potassium channels play an important role in maintaining the membrane transport in the renal proximal tubules (PT) and adenosine receptors have been shown to regulate the trans-epithelial Na+ absorption in the PT.
Hao Liu, Qi Sun, Zheng Ding, Wensen Shi, Wen-Hui Wang, Chengbiao Zhang   +5 more
doaj   +1 more source