Results 41 to 50 of about 4,325,962 (256)

The 2.6 Å Crystal Structure of a Human A2A Adenosine Receptor Bound to an Antagonist

Science, 2008
The adenosine class of heterotrimeric guanine nucleotide–binding protein (G protein)–coupled receptors (GPCRs) mediates the important role of extracellular adenosine in many physiological processes and is antagonized by caffeine.
Veli-Pekka Jaakola, M. Griffith, M. Hanson, V. Cherezov, E. Chien, J. R. Lane, A. IJzerman, R. Stevens   +7 more
semanticscholar   +1 more source

Adenosine receptors and cancer

Biochimica et Biophysica Acta (BBA) - Biomembranes, 2011
Adenosine is a ubiquitous signaling molecule whose physiological functions are mediated by its interaction with four G-protein-coupled receptor subtypes, termed A(1), A(2A), A(2B) and A(3). As a result of increased metabolic rates, this nucleoside is released from a variety of cells throughout the body in concentrations that can have a profound impact ...
GESSI, Stefania, MERIGHI, Stefania, SACCHETTO, Valeria, SIMIONI, Carolina, BOREA, Pier Andrea   +4 more
openaire   +3 more sources

Adenosine A1 receptor activation mediates the developmental shift at layer 5 pyramidal cell synapses and is a determinant of mature synaptic strength [PDF]

, 2013
During the first postnatal month glutamatergic synapses between layer 5 pyramidal cells in the rodent neocortex switch from an immature state exhibiting high probability of neurotransmitter release, large unitary amplitude and synaptic depression to a ...
Richardson, Magnus J. E., Kerr, Michael I., Wall, Mark J.   +2 more
core   +1 more source

Adenosine Receptor-Mediated Cardioprotection—Current Limitations and Future Directions

Frontiers in Pharmacology, 2018
Since the seminal reports of adenosine receptor-mediated cardioprotection in the early 1990s, there have been a multitude of such reports in various species and preparations.
Robert D. Lasley
doaj   +1 more source

The implication of adenosine receptor expression in prediction of methotrexate clinical response in Egyptian rheumatoid arthritis patients

Egyptian Rheumatology and Rehabilitation, 2022
Background Adenosine signaling is now an accepted explanation for the therapeutic mechanism of Methotrexate (MTX) in rheumatoid arthritis (RA). Adenosine receptors categorized into four subclasses: adenosine A1 receptor (ADORA1), adenosine 2a receptor ...
Nivine Fathi Darwish, Samar Abd Alhamed Tabra, Nivin Naeem Baiomy, Heba A. Mahmoud, Reham A. Mariah, Shymaa Ahmed Hablas   +5 more
doaj   +1 more source

Adenosine A2A Receptor Blockade as an Immunotherapy for Treatment-Refractory Renal Cell Cancer

Cancer Discovery, 2019
Adenosine mediates immunosuppression within the tumor microenvironment through triggering adenosine 2A receptors (A2AR) on immune cells. To determine whether this pathway could be targeted as an immunotherapy, we performed a phase 1 clinical trial with a
L. Fong, A. Hotson, J. Powderly, M. Sznol, R. Heist, T. Choueiri, S. George, B. Hughes, M. Hellmann, D. Shepard, B. Rini, S. Kummar, A. Weise, M. Riese, B. Markman, L. Emens, D. Mahadevan, J. Luke, G. Laport, J. Brody, L. Hernandez-Aya, P. Bonomi, J. Goldman, L. Berim, D. Renouf, R. Goodwin, Brian Munneke, P. Ho, J. Hsieh, I. McCaffery, L. Kwei, S. Willingham, Richard A. Miller   +32 more
semanticscholar   +1 more source

Intracellular ATP influences synaptic plasticity in area CA1 of rat hippocampus via metabolism to adenosine and activity-dependent activation of adenosine A1 receptors [PDF]

, 2011
The extent to which brain slices reflect the energetic status of the in vivo brain has been a subject of debate. We addressed this issue to investigate the recovery of energetic parameters and adenine nucleotides in rat hippocampal slices and the ...
D. Grahame Hardie, Hardie, D. G. (D. Grahame), Naomi Pentland, Simon Hawley, Frenguelli, Bruno, Doney, Alexander S., Pentland, Naomi, Frenguelli, Bruno G., Stephanie zur Nedden, Hawley, Simon, Alexander S. Doney, Bruno G. Frenguelli, Hardie, D. Grahame, Doney, Alexander S.; id_orcid, Zur Nedden, Stephanie   +14 more
core   +1 more source

A2A Adenosine Receptor antagonists to weaken the hypoxia-HIF-1α driven immunosuppression and improve immunotherapies of cancer

Current opinion in pharmacology (Print), 2016
Hypoxic and adenosine rich tumor microenvironments represent an important barrier that must be overcome to enable T and NK cells to reject tumors. The A2A adenosine receptor (A2AR) on activated immune cells was identified as a critical and non-redundant ...
S. Hatfield, M. Sitkovsky
semanticscholar   +1 more source

Adenosine Receptors and the Kidney [PDF]

, 2009
The autacoid, adenosine, is present in the normoxic kidney and generated in the cytosol as well as at extracellular sites. The rate of adenosine formation is enhanced when the rate of ATP hydrolysis prevails over the rate of ATP synthesis during increased tubular transport work or during oxygen deficiency.
Volker, Vallon, Hartmut, Osswald
openaire   +2 more sources

Low expression of CD39 and CD73 genes in centenarians compared with octogenarians

Immunity & Ageing, 2017
Ageing involves a progressive decline of the body’s regulatory systems including immune system. Adenosine regulates immune function by interaction with its receptors, mainly adenosine A2A receptor, present on the surface of immune cells.
Almudena Crooke, Juan Martínez-Henández, Joaquín Martínez-López, Alfonso Cruz-Jentoft, Fernando Huete-Toral, Jesús Pintor   +5 more
doaj   +1 more source