Results 1 to 10 of about 11,166,099 (105)

The influence of the way of regression on the results obtained by the receptorial responsiveness method (RRM), a procedure to estimate a change in the concentration of a pharmacological agonist near the receptor [PDF]

Frontiers in Pharmacology, 2023
The receptorial responsiveness method (RRM) enables the estimation of a change in concentration of an (even degradable) agonist, near its receptor, via curve fitting to (at least) two concentration-effect (E/c) curves of a stable agonist.
Ignac Ovari, Ignac Ovari, Gabor Viczjan, Tamas Erdei, Barbara Takacs, Vera Tarjanyi, Judit Zsuga, Miklos Szucs, Zoltan Szilvassy, Bela Juhasz, Rudolf Gesztelyi   +10 more
doaj   +8 more sources

Accuracy and Precision of the Receptorial Responsiveness Method (RRM) in the Quantification of A1 Adenosine Receptor Agonists [PDF]

International Journal of Molecular Sciences, 2019
The receptorial responsiveness method (RRM) is a procedure that is based on a simple nonlinear regression while using a model with two variables (X, Y) and (at least) one parameter to be determined (cx). The model of RRM describes the co-action of two agonists that consume the same response capacity (due to the use of the same postreceptorial signaling
Adrienn Monika Szabo, Gabor Viczjan, Tamas Erdei, Ildiko Simon, Rita Kiss, Andras Jozsef Szentmiklosi, Bela Juhasz, Csaba Papp, Judit Zsuga, Akos Pinter, Zoltan Szilvassy, Rudolf Gesztelyi   +11 more
europepmc   +6 more sources

Methodical Challenges and a Possible Resolution in the Assessment of Receptor Reserve for Adenosine, an Agonist with Short Half-Life [PDF]

Molecules, 2017
The term receptor reserve, first introduced and used in the traditional receptor theory, is an integrative measure of response-inducing ability of the interaction between an agonist and a receptor system (consisting of a receptor and its downstream ...
Judit Zsuga, Tamas Erdei, Katalin Szabó, Nora Lampe, Csaba Papp, Akos Pinter, Andras Jozsef Szentmiklosi, Bela Juhasz, Zoltán Szilvássy, Rudolf Gesztelyi   +9 more
doaj   +4 more sources

FSCPX, a Chemical Widely Used as an Irreversible A1 Adenosine Receptor Antagonist, Modifies the Effect of NBTI, a Nucleoside Transport Inhibitor, by Reducing the Interstitial Adenosine Level in the Guinea Pig Atrium [PDF]

Molecules, 2018
Based on in silico results, recently we have assumed that FSCPX, an irreversible A1 adenosine receptor antagonist, inhibits the action of NBTI that is apparent on E/c curves of adenosine receptor agonists.
Tamas Erdei, Adrienn Monika Szabo, Nora Lampe, Katalin Szabo, Rita Kiss, Judit Zsuga, Csaba Papp, Akos Pinter, Andras Jozsef Szentmiklosi, Zoltan Szilvassy, Bela Juhasz, Rudolf Gesztelyi   +11 more
doaj   +4 more sources

The effect of a long-term treatment with cannabidiol-rich hemp extract oil on the adenosinergic system of the zucker diabetic fatty (ZDF) rat atrium [PDF]

Frontiers in Pharmacology, 2022
Cannabidiol (CBD), the most extensively studied non-intoxicating phytocannabinoid, has been attracting a lot of interest worldwide owing to its numerous beneficial effects.
Gabor Viczjan, Gabor Viczjan, Anna Szilagyi, Barbara Takacs, Ignac Ovari, Reka Szekeres, Vera Tarjanyi, Tamas Erdei, Vanda Teleki, Judit Zsuga, Zoltan Szilvassy, Bela Juhasz, Balazs Varga, Rudolf Gesztelyi   +13 more
doaj   +2 more sources

An Advanced in Silico Modelling of the Interaction between FSCPX, an Irreversible A₁ Adenosine Receptor Antagonist, and NBTI, a Nucleoside Transport Inhibitor, in the Guinea Pig Atrium [PDF]

Molecules, 2019
In earlier studies, we generated concentration-response (E/c) curves with CPA (N6-cyclopentyladenosine; a selective A1 adenosine receptor agonist) or adenosine, in the presence or absence of S-(2-hydroxy-5-nitrobenzyl)-6-thioinosine (NBTI, a selective ...
Adrienn Monika Szabo, Tamas Erdei, Gabor Viczjan, Rita Kiss, Judit Zsuga, Csaba Papp, Akos Pinter, Bela Juhasz, Zoltan Szilvassy, Rudolf Gesztelyi   +9 more
doaj   +2 more sources

The interaction of AB-680, a CD73 inhibitor, with NBTI, a nucleoside transporter inhibitor, on the adenosinergic control of atrial contractility [PDF]

Frontiers in Pharmacology
IntroductionIn this study, we investigated the influence of AB-680, a highly potent CD73 inhibitor, on the effect of NBTI, a nucleoside transport blocker, exerted on concentration-effect (E/c) curves generated with CPA, a relatively stable, selective A1 ...
Ignac Ovari, Agnes Boglarka Brezniczky, Attila Laczovics, Ervin Berényi, Tamas Erdei, Oluwatofunmi Ojo, Bence Hornok, Bela Juhasz, Zoltan Szilvassy, Judit Zsuga, Gabor Viczjan, Rudolf Gesztelyi   +11 more
doaj   +2 more sources

[The receptorial responsiveness method (RRM): a new possibility to estimate the concentration of pharmacologic agonists at their receptors].

Acta pharmaceutica Hungarica, 2014
Cardiovascular disease is the biggest challenge in terms of life expectancy in developed countries. Adenosine contributes to the adaptation of the heart to ischemia and hypoxia, because adenosine, in addition to its metabolite role in the nucleic acid metabolism, is the endogenous agonist of the ubiquitous adenosine receptor family.
Krisztián, Pák, Zsuzsanna, Kiss, Tamás, Erdei, Zita, Képes, Rudolf, Gesztelyi   +4 more
openaire   +1 more source

Development of a versatile LCM-Seq method for spatial transcriptomics of fluorescently tagged cholinergic neuron populations. [PDF]

J Biol Chem, 2023
Rumpler É, Göcz B, Skrapits K, Sárvári M, Takács S, Farkas I, Póliska S, Papp M, Solymosi N, Hrabovszky E.   +9 more
europepmc   +1 more source

Prolactin and Growth Hormone Signaling and Interlink Focused on the Mammosomatotroph Paradigm: A Comprehensive Review of the Literature. [PDF]

Int J Mol Sci, 2023
Araujo-Castro M, Marazuela M, Puig-Domingo M, Biagetti B.   +3 more
europepmc   +1 more source