Results 1 to 10 of about 85 (60)

FSCPX, a Chemical Widely Used as an Irreversible A1 Adenosine Receptor Antagonist, Modifies the Effect of NBTI, a Nucleoside Transport Inhibitor, by Reducing the Interstitial Adenosine Level in the Guinea Pig Atrium [PDF]

Molecules, 2018
Based on in silico results, recently we have assumed that FSCPX, an irreversible A1 adenosine receptor antagonist, inhibits the action of NBTI that is apparent on E/c curves of adenosine receptor agonists.
Rudolf Gesztelyi, Béla Juhász, Katalin Szabó   +2 more
exaly   +9 more sources

An Advanced in Silico Modelling of the Interaction between FSCPX, an Irreversible A₁ Adenosine Receptor Antagonist, and NBTI, a Nucleoside Transport Inhibitor, in the Guinea Pig Atrium [PDF]

Molecules, 2019
In earlier studies, we generated concentration-response (E/c) curves with CPA (N6-cyclopentyladenosine; a selective A1 adenosine receptor agonist) or adenosine, in the presence or absence of S-(2-hydroxy-5-nitrobenzyl)-6-thioinosine (NBTI, a selective ...
Adrienn Monika Szabo, Tamas Erdei, Gabor Viczjan, Rita Kiss, Judit Zsuga, Csaba Papp, Akos Pinter, Bela Juhasz, Zoltan Szilvassy, Rudolf Gesztelyi   +9 more
doaj   +7 more sources

Methodical Challenges and a Possible Resolution in the Assessment of Receptor Reserve for Adenosine, an Agonist With Short Half-Life [PDF]

Molecules, 2017
The term receptor reserve, first introduced and used in the traditional receptor theory, is an integrative measure of response-inducing ability of the interaction between an agonist and a receptor system (consisting of a receptor and its downstream ...
Rudolf Gesztelyi, Béla Juhász, Katalin Szabó   +2 more
exaly   +7 more sources

A Body of Circumstantial Evidence for the Irreversible Ectonucleotidase Inhibitory Action of FSCPX, an Agent Known as a Selective Irreversible A₁ Adenosine Receptor Antagonist So Far. [PDF]

Int J Mol Sci, 2021
In previous studies using isolated, paced guinea pig left atria, we observed that FSCPX, known as a selective A1 adenosine receptor antagonist, paradoxically increased the direct negative inotropic response to A1 adenosine receptor agonists (determined using concentration/effect (E/c) curves) if NBTI, a nucleoside transport inhibitor, was present ...
Viczjan G, Erdei T, Ovari I, Lampe N, Szekeres R, Bombicz M, Takacs B, Szilagyi A, Zsuga J, Szilvassy Z, Juhasz B, Gesztelyi R.   +11 more
europepmc   +4 more sources

New Irreversible Adenosine A₁ Antagonists Based on FSCPX

ChemInform, 2002
AbstractFor Abstract see ChemInform Abstract in Full Text.
Department of Medicinal Chemistry, Victorian College of Pharmacy, Monash University Royal Parade, Parkville, Victoria 3052, Australia ( host institution ), Beauglehole, Anthony R, Baker, Stephen P, Scammells, Peter J   +3 more
core   +9 more sources

Differential A1-Adenosine Receptor Reserve for Inhibition of Cyclic AMP Accumulation and G-Protein Activation in DDT1 MF-2 Cells [PDF]

British Journal of Pharmacology, 2000
Peter J. Scammells, Stephen P Baker, L Belardinelli   +2 more
exaly   +2 more sources

Determination of Adenosine A1 Receptor Agonist and Antagonist Pharmacology Using Saccharomyces cerevisiae: Implications for Ligand Screening and Functional Selectivity [PDF]

Journal of Pharmacology and Experimental Therapeutics, 2009
Simon J Dowell, Patrick M. Sexton, Celine Valant   +2 more
exaly   +2 more sources

Validation of Furchgott's Method to Determine Agonist-Dependent A1-Adenosine Receptor Reserve in Guinea-Pig Atrium [PDF]

British Journal of Pharmacology, 1998
Donn M Dennis, T E Morey, L Belardinelli
exaly   +2 more sources

Tonic Activity of the Rat Adipocyte A1-Adenosine Receptor [PDF]

British Journal of Pharmacology, 2002
John C Shryock, Luiz Belardinelli
exaly   +2 more sources

Activation of Adenosine Low-Affinity A3 Receptors Inhibits the Enteric Short Interplexus Neural Circuit Triggered by Histamine

American Journal of Physiology - Renal Physiology, 2009
Fievos L Christofi, Helen J. Cooke, Jacqueline Wunderlich   +2 more
exaly   +2 more sources