Results 1 to 10 of about 980 (152)
Effect of caffeine and other xanthines on liver sinusoidal endothelial cell ultrastructure [PDF]
Scientific Reports, 2023 Xanthines such as caffeine and theobromine are among the most consumed psychoactive stimulants in the world, either as natural components of coffee, tea and chocolate, or as added ingredients.
Hong Mao +12 more
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Molecules, 2021 Antimicrobial resistance is a major healthcare threat globally. Xanthines, including caffeine and pentoxifylline, are attractive candidates for drug repurposing, given their well-established safety and pharmacological profiles.
Anna Woziwodzka +6 more
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Molecules, 2023 A series of novel 1-N-α-d-glucopyranosyl-1H-1,2,3-triazole xanthines was synthesized from azido sugars (glucose, galactose, and lactose) and propargyl xanthines (theophylline and theobromine) using a typical copper (I)-catalyzed azide–alkyne 1,3-dipolar ...
Alma Sánchez-Eleuterio +9 more
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Metals, 2022 Metals stability and corrosion resistance are very important factors that influence the possibility of their applications. In order to study and foresee the behavior of metals during various applications in all kinds of conditions and media, numerous ...
Marija B. Petrović Mihajlović +4 more
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Pharmaceuticals, 2021 As life expectancy increases, dementia affects a growing number of people worldwide. Besides current treatments, phosphodiesterase 9 (PDE9) represents an alternative target for developing innovative small molecules to contrast neurodegeneration.
Giovanni Ribaudo +2 more
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eLife, 2021 Mutations in TP53 occur commonly in the majority of human tumors and confer aggressive tumor phenotypes, including metastasis and therapy resistance. CB002 and structural-analogs restore p53 signaling in tumors with mutant-p53 but we find that unlike ...
Liz Hernandez Borrero +8 more
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Search for potential hypoglycemic agents among potassium salts of 3-benzyl-8-substituted xanthines
Aktualʹnì Pitannâ Farmacevtičnoï ì Medičnoï Nauki ta Praktiki, 2022 Nowadays, the prevalence of metabolic syndrome (MS) is a serious problem among the world’s population. Metabolic syndrome includes the so-called “deadly” quartet – hypertension, type 2 diabetes mellitus (diabetes mellitus), dyslipidemia and alimentary ...
K. V. Aleksandrova +4 more
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Zaporožskij Medicinskij Žurnal, 2021 Statin side effects are not a rare occurrence, in particular dyspeptic disorders, insomnia, headache, skin erythema, rash are often noted. All of this determines scientists to find new effective and low-toxic hypolipidemic agents.
I. M. Bilai +2 more
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Cells, 2021 Splicing defects caused by mutations in the consensus sequences at the borders of introns and exons are common in human diseases. Such defects frequently result in a complete loss of function of the protein in question.
Antje Banning, Ritva Tikkanen
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Salification Controls the In-Vitro Release of Theophylline
Crystals, 2022 Sustained released formulation is the most used strategy to control the efficacy and the adverse reactions of an API (active pharmaceutical ingredient) with a narrow therapeutic index.
Laura Baraldi +5 more
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