Results 31 to 40 of about 4,011 (296)
Selective Bronchodilators from 1-(5′-Oxohexyl)xanthines [PDF]
, 1992 A series of twenty one 1-(5′-oxohexyl)xanthines substituted with alkyl chains at the N 3 and N 7 positions of the xanthine nucleus were prepared and their relaxant activity in guinea-pig isolated tracheal muscle and positive chronotropic activity in ...
Ryosuke Sakai +6 more
core +1 more source
Aktualʹnì Pitannâ Farmacevtičnoï ì Medičnoï Nauki ta Praktiki, 2016 1,2,4-Triazole derivatives are successfully used in medicine as antibacterial and antifungal agents. Aim of our research is the study of synthesis of 7'-((3-thio-4-ethyl-4H-1,2,4-triazole-5-yl)methyl)-3'-methylxanthine. Methods and results.
A. S. Gotsulya
doaj +1 more source
FEBS Open Bio, 2019 In eukaryotic cells, cytoplasmic mRNA is characterised by a 3′ poly(A) tail. The shortening and removal of poly(A) tails (deadenylation) by the Ccr4‐Not nuclease complex leads to reduced translational efficiency and RNA degradation.
Blessing Airhihen +4 more
doaj +1 more source
Caffeine Citrate in Neonatal Intensive Care Unit [PDF]
Annals of Neonatology Journal, 2023 Apnea is a common condition in premature infants due to the immaturity of respiratory control mechanisms. Incidence increases with younger gestational age and lower birth weight, afflicting 25% of infants under 2500 g and 80% under 1000 g .
Afaf Korraa
doaj +1 more source
Effects of methylated xanthines on the neuronally isolated cerebral cortex [PDF]
, 1961 Although caffeine has long been considered to be a cerebral cortical stimulant, relatively little is known of its sites and mechanism of action in the cerebral cortex.
Domino, Edward F., Maiti, Ajit
core +1 more source
Aktualʹnì Pitannâ Farmacevtičnoï ì Medičnoï Nauki ta Praktiki, 2016 Introduction. Analysis of last years’ literature shows, that the most wide spread drugs are those, which contain in their structures heterocyclic fragment.
K. V. Аleksandrova +3 more
doaj +1 more source
Benefits under the Sea: The Role of Marine Compounds in Neurodegenerative Disorders
Marine Drugs, 2021 Marine habitats offer a rich reservoir of new bioactive compounds with great pharmaceutical potential; the variety of these molecules is unique, and its production is favored by the chemical and physical conditions of the sea.
Mariano Catanesi +5 more
doaj +1 more source
Hepatology, EarlyView., 2022 A deleterious variant of FCHSD1 results in mTOR pathway overactivation and may cause porto‐sinusoidal vascular disorder (PSVD). The pedigree of the family demonstrated an autosomal dominant disease with variable expressivity. Whole‐genome sequencing and Sanger sequencing both validated the existence of the FCHSD1 variant and the heterozygosity of c ...
Jingxuan Shan +19 more
wiley +1 more source
Biomolecules, 2019 This paper presents an analysis of the molecular mechanisms involved in the formation of inclusion complexes together with some structural interpretation of drug−carrier molecule interactions in aqueous multicomponent systems comprising ...
Cecília I. A. V. Santos +2 more
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The Effect of Lipopolysaccharide on the Disposition of Xanthines in Rats [PDF]
, 1993 The effect of lipopolysaccharide (LPS) isolated from Klebsiella pneumoniae O3 on the pharmacokinetic behaviour and metabolism of the xanthines, theophylline and 1-methyl-3-propylxanthine (MPX), which are mainly metabolized by the liver, was investigated ...
Isao Muraoka +5 more
core +1 more source