Results 31 to 40 of about 980 (152)
The adenosine A2A antagonistic properties of selected C8-substituted xanthines
, 2013 The adenosine A2A receptor is considered to be an important target for the development of new therapies for Parkinson’s disease. Several antagonists of the A2A receptor have entered clinical trials for this purpose and many research groups have ...
Petzer, Jacobus P. +4 more
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Recent Advances in the Synthesis of Xanthines: A Short Review
Scientifica, 2022 Xanthine and its derivatives are considered a pharmacologically potential moiety that manifests immense biological activities. Owing to this much diversity in the biological field, this scaffold has fascinated the attention of many researchers around the
Anandi Kapri, Nitin Gupta, Sumitra Nain
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Double C−H Activation: The Palladium-Catalyzed Direct C-Arylation of Xanthines with Arenes
, 2016 The novel Pd-catalyzed C(sp2)−H/C(sp2)−H cross-coupling of unactivated xanthines with unactivated arenes utilizing a combination of Ag(I) and O2 as oxidants exclusively yields C-8 arylated xanthines in a single synthetic ...
Chandi C. Malakar (1490242) +3 more
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Xanthine oxidoreductase and xanthine oxidase in human cornea.
Histology and histopathology, 2002 Xanthine oxidoreductase (xanthine dehydrogenase + xanthine oxidase) is a complex enzyme that catalyzes the oxidation of hypoxanthine to xanthine, subsequently producing uric acid. The enzyme complex exists in separate but interconvertible forms, xanthine dehydrogenase and xanthine oxidase, which generate reactive oxygen species (ROS), a well known ...
Cejkova, J. +3 more
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Selective Bronchodilators from 1-(5′-Oxohexyl)xanthines
, 1992 A series of twenty one 1-(5′-oxohexyl)xanthines substituted with alkyl chains at the N 3 and N 7 positions of the xanthine nucleus were prepared and their relaxant activity in guinea-pig isolated tracheal muscle and positive chronotropic activity in ...
Ryosuke Sakai +6 more
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The Transcriptional Repressor Orphan Nuclear Receptor TLX Is Responsive to Xanthines
, 2021 [Image: see text] The orphan nuclear receptor tailless homologue (TLX) is expressed almost exclusively in neural stem cells acting as an essential factor for their survival and is hence considered as a promising drug target in neurodegeneration. However,
Knapp, Stefan +21 more
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New and Practical Method for Synthesis of 1- and 1,3-Substituted Xanthines
, 2016 A new and practical method for the synthesis of 1- and 1,3-substituted xanthines is reported. Direct base-promoted condensation of the imidazole precursor 1 with carbamates 2 gives 1-substituted 7-PMB xanthines 7 in good yields.
Cecilia Orr (2714416) +4 more
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The study of reactions of 7-substituted 8-hydrazino-3-methylxanthine with β-dicarbonyl compounds
Aktualʹnì Pitannâ Farmacevtičnoï ì Medičnoï Nauki ta Praktiki, 2015 The problem of searching biologically active compounds amidst xanthine derivatives is a crucial one and is an issue for long-term investigation.
N. I. Romanenko +4 more
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Frontiers in Chemistry, 2019 Substituted xanthine derivatives are important bioactive molecules. Herein we report on a new, practical synthesis of 6-amino-5-carboxamidouracils, the main building blocks for the preparation of 8-substituted xanthines, by condensation of 5,6 ...
Daniel Marx +4 more
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Digging into biochemical and signal transduction of old drugs: xanthines and their association to cancer [PDF]
ERU Research JournalThe arena of anticancer drug research has identified xanthine derivatives as intriguing molecules with diverse antimutagenic capabilities against a variety of cancer disorders.
Abdalla Mohamed
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