Results 21 to 30 of about 980 (152)

The cardiovascular effects of xanthines and selective PDE inhibitors: a risk–benefit analysis

, 2020
Xanthines have been employed in the treatment of respiratory disorders since 1937, for the treatment of respiratory diseases such as COPD and asthma. However, xanthines, although effective, have a relatively narrow therapeutic window that has limited ...
Roberta Fusco, Cuzzocrea, Salvatore, Clive Page, Di Paola, Rosanna, Page, Clive, Fusco, Roberta, Salvatore Cuzzocrea, Maria Gabriella Matera, Rosanna Di Paola, Matera, Maria Gabriella, Fusco R., Cuzzocrea S., Di Paola R., Page C., Matera M. G.   +14 more
core   +1 more source

Synthesis and Medicinal Applications of N-Heterocyclic Carbene Complexes Based on Caffeine and Other Xanthines [PDF]

Xanthines are purine derivatives predominantly found in plants. Xanthines include compounds such as caffeine, theophylline, and theobromine and exhibit a variety of pharmacological properties, demonstrating efficacy in treating neurodegenerative ...
Ana, Petronilho, Maria Ines , Leitao, Giulia, Orsini, Giulia, Francescato   +3 more
core   +2 more sources

Synthesis and research on properties of 2-(4-еthyl-5-((3'-methylxantine-7'-yl)methyl)-4H-1,2,4-triazole-3-ylthio)acetic acid’s salts

Aktualʹnì Pitannâ Farmacevtičnoï ì Medičnoï Nauki ta Praktiki, 2016
1,2,4-Triazole derivatives are successfully used in medicine as antibacterial and antifungal agents. Aim of our research is the study of synthesis of 7'-((3-thio-4-ethyl-4H-1,2,4-triazole-5-yl)methyl)-3'-methylxanthine. Methods and results.
A. S. Gotsulya
doaj   +1 more source

Microwave-assisted reactions: Efficient and versatile one-step synthesis of 8-substituted xanthines and substituted pyrimidopteridine-2,4,6,8-tetraones under controlled microwave heating

Green Processing and Synthesis, 2021
A green, simple one-pot microwave-assisted synthesis of xanthines and pyrimidopetridines was developed with a high EcoScale and yields.
Mekheimer Ramadan Ahmed, Hayallah Alaa M., Moustafa Moustafa Sherief, Al-Mousawi Saleh Mohammed, Abd-Elmonem Mohamed, Mostafa Sara M., Abo Elsoud Fatma A., Sadek Kamal Usef   +7 more
doaj   +1 more source

1‐Hydroxy‐xanthine derivatives inhibit the human Caf1 nuclease and Caf1‐containing nuclease complexes via Mg2+‐dependent binding

FEBS Open Bio, 2019
In eukaryotic cells, cytoplasmic mRNA is characterised by a 3′ poly(A) tail. The shortening and removal of poly(A) tails (deadenylation) by the Ccr4‐Not nuclease complex leads to reduced translational efficiency and RNA degradation.
Blessing Airhihen, Lorenzo Pavanello, Gopal P. Jadhav, Peter M. Fischer, Gerlof Sebastiaan Winkler   +4 more
doaj   +1 more source

Caffeine Citrate in Neonatal Intensive Care Unit [PDF]

Annals of Neonatology Journal, 2023
Apnea is a common condition in premature infants due to the immaturity of respiratory control mechanisms. Incidence increases with younger gestational age and lower birth weight, afflicting 25% of infants under 2500 g and 80% under 1000 g .
Afaf Korraa
doaj   +1 more source

Synthesis and physical-chemical properties of 3-aryl-(aralkyl)-8-hydrazinemethylxanthines and their N-substituted derivatives

Aktualʹnì Pitannâ Farmacevtičnoï ì Medičnoï Nauki ta Praktiki, 2016
Introduction. Analysis of last years’ literature shows, that the most wide spread drugs are those, which contain in their structures heterocyclic fragment.
K. V. Аleksandrova, S. V. Levich, Ye. K. Mikhalchenko, D. M. Sinchenko   +3 more
doaj   +1 more source

Benefits under the Sea: The Role of Marine Compounds in Neurodegenerative Disorders

Marine Drugs, 2021
Marine habitats offer a rich reservoir of new bioactive compounds with great pharmaceutical potential; the variety of these molecules is unique, and its production is favored by the chemical and physical conditions of the sea.
Mariano Catanesi, Giulia Caioni, Vanessa Castelli, Elisabetta Benedetti, Michele d’Angelo, Annamaria Cimini   +5 more
doaj   +1 more source

Effects of methylated xanthines on the neuronally isolated cerebral cortex [PDF]

, 1961
Although caffeine has long been considered to be a cerebral cortical stimulant, relatively little is known of its sites and mechanism of action in the cerebral cortex.
Domino, Edward F., Maiti, Ajit
core   +1 more source

Drug Delivery Systems: Study of Inclusion Complex Formation between Methylxanthines and Cyclodextrins and Their Thermodynamic and Transport Properties

Biomolecules, 2019
This paper presents an analysis of the molecular mechanisms involved in the formation of inclusion complexes together with some structural interpretation of drug−carrier molecule interactions in aqueous multicomponent systems comprising ...
Cecília I. A. V. Santos, Ana C. F. Ribeiro, Miguel A. Esteso   +2 more
doaj   +1 more source