Results 21 to 30 of about 4,011 (296)
Effects of early aminophylline therapy on clinical outcomes in premature infants
Pediatrics and Neonatology, 2023 Background: Aminophylline use and the association between clinical outcomes and therapy timing have been less investigated. The objective of this study was to determine the efficacy of early aminophylline use (within the first two days of life) in ...
Yi-Ting Chu +6 more
doaj +1 more source
Xanthine urolithiasis: Inhibitors of xanthine crystallization
PLOS ONE, 2018 Abstract OBJECTIVE To identify in vitro inhibitors of xanthine crystallization that have potential for inhibiting the formation of xanthine crystals in urine and preventing the development of the renal calculi in patients with xanthinuria.
Grases, Felix +3 more
openaire +5 more sources
New and Practical Method for Synthesis of 1- and 1,3-Substituted Xanthines [PDF]
, 2016 A new and practical method for the synthesis of 1- and 1,3-substituted xanthines is reported. Direct base-promoted condensation of the imidazole precursor 1 with carbamates 2 gives 1-substituted 7-PMB xanthines 7 in good yields.
Cecilia Orr (2714416) +4 more
core +1 more source
Molecules, 2021 The xanthine-derivatives 1,3,7-trimethylxanthine, 1,3-dimethyl-7-benzylxanthine and 1,3-dimethyl-7-(4-chlorobenzyl)xanthine are readily ethylated at N9 using the cheap alkylating agents ethyl tosylate or diethyl sulfate. The resulting xanthinium tosylate
Moloud Mokfi +3 more
doaj +1 more source
Aktualʹnì Pitannâ Farmacevtičnoï ì Medičnoï Nauki ta Praktiki, 2017 Introduction. Synthetic research of new biologically active compounds occupies an important place in modern pharmaceutical science.Thus it is important to develop techniques for the biologically active substances functionalization. Esters and amides take
E. K. Mikhal’chenko +3 more
doaj +1 more source
Biotechnology & Biotechnological Equipment, 2022 This study is focused on determination of the most appropriate synthetic approach for obtaining series of theophylline-7-acetyl semi- and thiosemicarbazide hybrids by using the molecular hybridization strategy with and without a catalyst.
Javor Mitkov +4 more
doaj +1 more source
Xanthine dehydrogenase/xanthine oxidase and oxidative stress [PDF]
AGE, 1997 Xanthine dehydrogenase (XDH) and xanthine oxidase (XOD) are single-gene products that exist in separate but interconvertible forms. XOD utilizes hypoxanthine or xanthine as a substrate and O2 as a cofactor to produce superoxide (·O2 (-)) and uric acid.
H Y, Chung +7 more
openaire +2 more sources
Double C−H Activation: The Palladium-Catalyzed Direct C-Arylation of Xanthines with Arenes [PDF]
, 2016 The novel Pd-catalyzed C(sp2)−H/C(sp2)−H cross-coupling of unactivated xanthines with unactivated arenes utilizing a combination of Ag(I) and O2 as oxidants exclusively yields C-8 arylated xanthines in a single synthetic ...
Chandi C. Malakar (1490242) +3 more
core +1 more source
Aktualʹnì Pitannâ Farmacevtičnoï ì Medičnoï Nauki ta Praktiki, 2017 Introduction. Heterocyclic compounds play an important role in the metabolic processes of human organism. Structures of vitamins, nucleotides, chromoproteins are based on Nitrogen-containing heterocycles (purine, pyrimidine, thiazole etc).
E. K. Mikhalchenko +3 more
doaj +1 more source
The adenosine A2A antagonistic properties of selected C8-substituted xanthines [PDF]
, 2013 The adenosine A2A receptor is considered to be an important target for the development of new therapies for Parkinson’s disease. Several antagonists of the A2A receptor have entered clinical trials for this purpose and many research groups have ...
Petzer, Jacobus P. +4 more
core +1 more source