Results 41 to 50 of about 4,011 (296)

1,3,7-Triethyl-substituted xanthines-possess nanomolar affinity for the adenosine A1 receptor [PDF]

, 2015
Adenosine A1 receptors are attracting great interest as drug targets for their role in cognitive deficits. Antagonism of the adenosine A1 receptor may offer therapeutic benefits in complex neurological diseases, such as Alzheimer’s and Parkinson’s ...
Terre'Blanche, Gisella, Van der Walt, Mietha M.   +1 more
core   +1 more source

Xanthine oxidoreductase and xanthine oxidase in human cornea.

Histology and histopathology, 2002
Xanthine oxidoreductase (xanthine dehydrogenase + xanthine oxidase) is a complex enzyme that catalyzes the oxidation of hypoxanthine to xanthine, subsequently producing uric acid. The enzyme complex exists in separate but interconvertible forms, xanthine dehydrogenase and xanthine oxidase, which generate reactive oxygen species (ROS), a well known ...
Cejkova, J., Ardan, T., Filipec, M., Midelfart, A.   +3 more
openaire   +3 more sources

Sudden anaerobization in Amphibacillus xylanus increases intracellular labile ferrous iron and inhibits cell growth

FEBS Open Bio, EarlyView.
Abruptly changing from aerobic to anaerobic conditions (sudden anaerobization) induced growth inhibition and a significant increase in intracellular labile ferrous iron in the aerotolerant anaerobe Amphibacillus xylanus. We found that free flavins mediate efficient electron transfer from NADH to ferric iron under anaerobic conditions, suggesting that ...
Shinya Kimata, Yoichi Sakai, Keisuke Tanaka, Etsuro Yoshimura, Ken Kitano, Morio Ishikawa, Tadahiro Nakamoto, Tsutomu Takayama, Hirofumi Inoue, Kaho Nomura, Tomonori Suzuki, Masataka Uchino, Akira Abe, Youichi Niimura   +13 more
wiley   +1 more source

3-Substituted Xanthines as Promising Candidates for Quadruplex Formation: Computational, Synthetic and Analytical Studies [PDF]

, 2011
Our computational studies suggest that 3-substituted xanthines are good candidates for tetrad and quadruplex structures. 3-Methylxanthine (3MX) has been synthesized from 7-benzylxanthine, and the existence of tetrameric and octameric aggregates of 3MX ...
Fonseca Guerra, C., Bickelhaupt, F.M., Kele, Z., Célia Fonseca Guerra, Gyula Batta, Zoltán Kupihár, Pádár, P., Zupihára, Z., Zoltán Kele, Petra Pádár, Szolomájer, J., Kovács, L., János Szolomájer, Batta, G., Gábor Paragi, F. Matthias Bickelhaupt, Paragi, G., Fonseca Guerra, C.; id_orcid, Lajos Kovács   +18 more
core   +1 more source

Cyclic azapeptide CD36 ligand attenuates cardiac injury and reduces long‐chain fatty acid accumulation after myocardial ischemia–reperfusion in mice

FEBS Open Bio, EarlyView.
In a murine model of myocardial ischemia and reperfusion (MI/R), the CD36 azapeptide ligand MPE‐298 reduces cardiac injury and transiently lowers left ventricular long‐chain fatty acids (LCFAs) accumulation 3 h after reperfusion, accompanied by a decrease of oxidative stress and inflammation‐associated genes' expression in the heart and adipose tissue.
Jade Gauvin, Naghme Radmannia, David N. Huynh, Liliane Ménard, Caroline Daneault, Maïté Veilleux, Ahsanullah Ahsanullah, André C. Carpentier, William D. Lubell, Matthieu Ruiz, Huy Ong, Sylvie Marleau, Simon‐Pierre Gravel   +12 more
wiley   +1 more source

Measurements of Solubilities of Xanthines in Supercritical Carbon Dioxide + Methanol [PDF]

, 1995
Solubilities of the xanthines caffeine, theophylline, and theobromine in different supercritical (carbon dioxide + methanol) mixtures were measured at 313 K and 22 MPa.
Johannsen, Monika, Brunner, Gerd
core  

Effects of IGFBP4 deficiency on human preadipocyte proliferation and differentiation through the IGF1R/AKT pathway

FEBS Open Bio, EarlyView.
IGFBP4 knockdown (KD) impairs preadipocyte proliferation and is associated with IGF1R protein downregulation and attenuated AKT phosphorylation. The mechanisms by which IGFBP4 KD influences the IGF1R/AKT signaling pathway involve newly synthesized proteins and lysosomal degradation pathways. Created in BioRender.
Yujia Guo, Sandy Richter, Christoph Bach, Wieland Kiess, Anna Kirstein, Diana Le Duc, Antje Garten   +6 more
wiley   +1 more source

The study of reactions of 7-substituted 8-hydrazino-3-methylxanthine with β-dicarbonyl compounds

Aktualʹnì Pitannâ Farmacevtičnoï ì Medičnoï Nauki ta Praktiki, 2015
The problem of searching biologically active compounds amidst xanthine derivatives is a crucial one and is an issue for long-term investigation.
N. I. Romanenko, M. V. Nazarenko, D. G. Ivanchenko, O. O. Pakhomova, T. A. Sharapova   +4 more
doaj   +1 more source

Smart Antibacterial Coatings: Harnessing Bacterial Redox Activity for Infection Control

Advanced Materials Interfaces, EarlyView.
In this study, we have shown that ceftazidime‐loaded poly(3,4‐ethylenedioxythiophene) (PEDOT@CAZ) functions as a smart, redox‐responsive antibacterial coating that couples bacterial electrical activity with localized antibiotic delivery. Shewanella oneidensis and Pseudomonas aeruginosa induced distinct redox responses in PEDOT, reflecting their ...
Abdullah, Szymon Smołka, Kamran Ayaz, Sara Shakibania, Sajida Maryam, Taral Patel, Roman Turczyn, Ewa Zabłocka‐Godlewska, Katarzyna Krukiewicz   +8 more
wiley   +1 more source

Chromatographic behavior of xanthines in aqueous normal phase chromatography using titania stationary phase [PDF]

, 2011
International audienceThe chromatographic behavior of native titania was investigated in aqueous normal phase chromatography using a set of N-methylated xanthines as polar test solutes.
Abi Jaoudé, Maguy, Randon, Jérôme, Maguy Abi Jaoudé, Jérôme Randon   +3 more
core   +1 more source