The Mechanism and Significance of the Conversion of Xanthine Dehydrogenase to Xanthine Oxidase in Mammalian Secretory Gland Cells [PDF]
Redox Biology, 2023 The conversion of xanthine dehydrogenase (XDH) to xanthine oxidase (XO) occurs only in mammalian species. In fresh bovine milk, the enzyme exists predominantly as the oxidase form, in contrast to various normal organs where it is found primarily as the ...
Teruo Kusano +2 more
exaly +4 more sources
Absence of xanthine oxidase or xanthine dehydrogenase in the rabbit myocardium [PDF]
Biochemical and Biophysical Research Communications, 1986 We directly measured the activity of the enzymes xanthine oxidase and xanthine dehydrogenase in rabbit and rat hearts, using a sensitive radiochemical assay. Neither xanthine oxidase activity nor xanthine dehydrogenase activity was detected in the rabbit heart.
Grum, Cyril M. +3 more
core +8 more sources
Identification of a new mutation in the human xanthine dehydrogenase responsible for xanthinuria type I [PDF]
Advances in Laboratory Medicine, 2021 Hereditary xanthinuria is a rare, autosomal and recessive disorder characterized by severe hypouricemia and increased xanthine excretion, caused by a deficiency of xanthine dehydrogenase/oxidase (XDH/XO, EC: 1.17.1.4/1.17.3.2) in type I, or by a ...
Collazo Abal Cristina +5 more
doaj +2 more sources
Catalytic Electrochemistry of Xanthine Dehydrogenase
The Journal of Physical Chemistry B, 2012 We report the mediated electrocatalytic voltammetry of the molybdoenzyme xanthine dehydrogenase (XDH) from Rhodobacter capsulatus at a thiol-modified Au electrode. The 2-electron acceptor N-methylphenazinium methanesulfonate (phenazine methosulfate, PMS) is an effective artificial electron transfer partner for XDH instead of its native electron ...
Kalimuthu, Palraj +2 more
openaire +7 more sources
Determination of Flavin Potential in Proteins by Xanthine/Xanthine Oxidase Method
Bio-Protocol, 2020 This protocol describes a simple xanthine/xanthine oxidase enzymatic equilibration method for determination of the redox potential of a flavin. As an example of the use of this method, we determine the reduction potential of the covalently bound FAD ...
Elena Maklashina, Gary Cecchini
doaj +2 more sources
Effects of Cherry in Take Versus Allopurinol on Serum Uric Acid Levels, Biomarkers of Oxidative Stress and Hepatic Xanthine Oxidase/Xanthine Dehydrogenase Activity in Hyperuricemic Rats [PDF]
Majallah-i Dānishgāh-i ̒Ulūm-i Pizishkī-i Qum, 2008 Background and ObjectivesPrevention and treatment of hyperuricemia are based on control of uric acid levels. The aim of this study was to investigate the effect of oral administration of sour cherry and allopurinol on serum uric acid levels, biomarkers ...
F. Haidari +4 more
doaj +3 more sources
Xanthine Dehydrogenase Electrocatalysis: Autocatalysis and Novel Activity
The Journal of Physical Chemistry B, 2011 The enzyme xanthine dehydrogenase (XDH) from the purple photosynthetic bacterium Rhodobacter capsulatus catalyzes the oxidation of hypoxanthine to xanthine and xanthine to uric acid as part of purine metabolism. The native electron acceptor is NAD(+) but herein we show that uric acid in its 2-electron oxidized form is able to act as an artificial ...
Kalimuthu, Palraj +2 more
openaire +7 more sources
Regulation of xanthine dehydrogenase and xanthine oxidase activity by hypoxia
American Journal of Physiology-Lung Cellular and Molecular Physiology, 1996 The present study determined the effect of hypoxia on xanthine dehydrogenase (XDH) and xanthine oxidase (XO) activity and gene and protein expression in cultured bovine aortic endothelial cells (BAEC). BAEC were exposed to hypoxia (3% O2) or anoxia (0% O2) for 24 or 48 h and to 24 h of hypoxia followed by 24 h of reoxygenation.
W B, Poss +4 more
openaire +3 more sources
A rice XANTHINE DEHYDROGENASE gene regulates leaf senescence and response to abiotic stresses
Crop Journal, 2022 Xanthine dehydrogenase, a member of the molybdenum enzyme family, participates in purine metabolism and catalyzes the generation of ureides from xanthine and hypoxanthine.
Jiangmin Xu +11 more
doaj +1 more source
Xanthine dehydrogenase/xanthine oxidase and oxidative stress [PDF]
AGE, 1997 Xanthine dehydrogenase (XDH) and xanthine oxidase (XOD) are single-gene products that exist in separate but interconvertible forms. XOD utilizes hypoxanthine or xanthine as a substrate and O2 as a cofactor to produce superoxide (·O2 (-)) and uric acid.
H Y, Chung +7 more
openaire +2 more sources