Results 1 to 10 of about 17,774 (187)

The mechanism and significance of the conversion of xanthine dehydrogenase to xanthine oxidase in mammalian secretory gland cells [PDF]

Redox Biology, 2023
The conversion of xanthine dehydrogenase (XDH) to xanthine oxidase (XO) occurs only in mammalian species. In fresh bovine milk, the enzyme exists predominantly as the oxidase form, in contrast to various normal organs where it is found primarily as the ...
Teruo Kusano, Takeshi Nishino, Ken Okamoto   +2 more
exaly   +4 more sources

Identification of a new mutation in the human xanthine dehydrogenase responsible for xanthinuria type I [PDF]

Advances in Laboratory Medicine, 2021
Hereditary xanthinuria is a rare, autosomal and recessive disorder characterized by severe hypouricemia and increased xanthine excretion, caused by a deficiency of xanthine dehydrogenase/oxidase (XDH/XO, EC: 1.17.1.4/1.17.3.2) in type I, or by a ...
Collazo Abal Cristina, Romero Santos Susana, González Mao Carmen, Pazos Lago Emilio C., Barros Angueira Francisco, Castiñeiras Ramos Daisy   +5 more
doaj   +2 more sources

Potent and Sustained Lowering of Serum Uric Acid by YJH‐012‐D, a GalNAc‐Conjugated siRNA Targeting Xanthine Dehydrogenase

Pharmacology Research & Perspectives
Hyperuricemia (HUA) is primarily driven by hepatic overproduction of urate, mediated by xanthine dehydrogenase (XDH). This preclinical study evaluates YJH‐012‐D, a N‐acetylgalactosamine (GalNAc)‐conjugated small interfering RNA (siRNA) targeting hepatic ...
Tingke Tang, Qiuying Li, Chenguang Zhang, Yongxing Wang, Lu Yang, Haibin Huang, Yujun He, Zhi Zheng, Dong Liang, Meng Wang, Yingyu Wu, Chengjiang Zhao, Wenhao Cui   +12 more
doaj   +2 more sources

A rice XANTHINE DEHYDROGENASE gene regulates leaf senescence and response to abiotic stresses

Crop Journal, 2022
Xanthine dehydrogenase, a member of the molybdenum enzyme family, participates in purine metabolism and catalyzes the generation of ureides from xanthine and hypoxanthine.
Jiangmin Xu, Chenyang Pan, Han Lin, Hanfei Ye, Sheng Wang, Tao Lu, Qianyu Chen, Kairu Yang, Mei Lu, Qian Qian, Deyong Ren, Yuchun Rao   +11 more
doaj   +1 more source

Xanthine dehydrogenase/xanthine oxidase and oxidative stress [PDF]

AGE, 1997
Xanthine dehydrogenase (XDH) and xanthine oxidase (XOD) are single-gene products that exist in separate but interconvertible forms. XOD utilizes hypoxanthine or xanthine as a substrate and O2 as a cofactor to produce superoxide (·O2 (-)) and uric acid.
H Y, Chung, B S, Baek, S H, Song, M S, Kim, J I, Huh, K H, Shim, K W, Kim, K H, Lee   +7 more
openaire   +2 more sources

Association of Mutations Identified in Xanthinuria with the Function and Inhibition Mechanism of Xanthine Oxidoreductase

Biomedicines, 2021
Xanthine oxidoreductase (XOR) is an enzyme that catalyzes the two-step reaction from hypoxanthine to xanthine and from xanthine to uric acid in purine metabolism.
Mai Sekine, Ken Okamoto, Kimiyoshi Ichida   +2 more
doaj   +1 more source

Association of Xanthine Oxidase and Neutrophil Activation Marker Elastase in Preeclampsia: A Case-control Study [PDF]

Journal of Clinical and Diagnostic Research, 2021
Introduction: Preeclampsia is an obstetric emergency for both mother and the foetus with unknown aetiology. Delivery is the only effective way in the prompt management.
Ramya Rajshekar, Vanishree Bambrana, CHIKKANAYAKANAHALLI Doddaiah Dayanand, Payal Ray, D Radhika   +4 more
doaj   +1 more source

EVOLUTION OF XANTHINE DEHYDROGENASE IN DROSOPHILA [PDF]

Genetics, 1968
Uploaded by Plazi for TaxoDros. We do not have abstracts.
E J, Duke, E, Glassman
openaire   +3 more sources

Exogenous application of xanthine and uric acid and nucleobase-ascorbate transporter MdNAT7 expression regulate salinity tolerance in apple

BMC Plant Biology, 2021
Background Soil salinity is a critical threat to global agriculture. In plants, the accumulation of xanthine activates xanthine dehydrogenase (XDH), which catalyses the oxidation/conversion of xanthine to uric acid to remove excess reactive oxygen ...
Tingting Sun, Tingting Pei, Lulu Yang, Zhijun Zhang, Mingjun Li, Yuerong Liu, Fengwang Ma, Changhai Liu   +7 more
doaj   +1 more source

Oxidative stress in the pathogenesis of type 1 diabetes: the role of adipocyte xanthine oxidase

Бюллетень сибирской медицины, 2018
Rationale. According to modern understanding, oxidative stress plays an essential role in the underlying mechanisms for the emergence of type 1 and type 2 diabetes and development of complications in these conditions.
V. V. Ivanov, E. V. Shakhristova, E. A. Stepovaya, N. V. Litvjakov, N. A. Perekucha, O. L. Nosareva, T. S. Fedorova, V. V. Novitsky   +7 more
doaj   +1 more source