Results 21 to 30 of about 169,173 (169)
Alcool e radicais livres de oxigénio.
Acta Médica Portuguesa, 1993 Oxygen free radicals may be generated during ethanol metabolization by cytochrome P450, or due to the formation of xanthine oxidase by ethanol effect on xanthine dehydrogenase.
M L Mira, C F Manso
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Binding Modes of Xanthine‐Derived Selective Allosteric Site Inhibitors of MTHFD2
ChemistryOpen, 2023 Methylenetetrahydrofolate dehydrogenase (MTHFD2) is a mitochondrial enzyme involved in 1 C metabolism that is upregulated in various cancer cells, but absent in normal proliferating cells. Xanthine derivatives are the first selective inhibitors of MTHFD2
Dr. Vibhu Jha +1 more
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Nature Communications, 2019 The roles of the convertible forms, xanthine dehydrogenase (XDH) and xanthine oxidase (XO) during tumorigenesis is not known. Here, the authors develop XDH-stable and XO-locked knock-in (ki) mice and show increased tumor growth in XO ki mice, via ...
Teruo Kusano +11 more
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Classical xanthinuria: a rare cause of pediatric urolithiasis
Urology Research and Practice, 2019 Xanthine dehydrogenase catalyzes the oxidation of hypoxanthine to xanthine and xanthine to uric acid in the final two steps of purine degradation.
Nurver Akıncı +2 more
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XDH and XO Research and Drug Discovery—Personal History
Molecules, 2023 The author will outline the research history of the main issues addressed in this paper. The author has worked on this research himself. XDH, which is responsible for purine degradation, is present in various organisms.
Takeshi Nishino
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An in vitro System for Studying Pteridine Biosynthesis In Drosophila melanogaster
Pteridines, 1991 In vitro organ culture is a system especially useful for the study of metabolic pathways and their regulation. This report applies such a system to the study of the biosynthesis of pteridines in Drosophila melanogaster, determining in vitro optimal ...
Escriche B., Silva F. J.
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Some opportunities of using xanthine oxidase inhibitors
Современная ревматология, 2019 The review presents modern concepts of the role of xanthine oxidase (XO) in the pathogenesis of a number of diseases. It has been shown that XO activity can be associated with the development and progression not only of gout, but, possibly, diabetes ...
O. V. Zhelyabina, M. S. Eliseev
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Xanthine oxidoreductase: One enzyme for multiple physiological tasks
Redox Biology, 2021 Human xanthine oxidoreductase (XOR) is a multiple-level regulated enzyme, resulting from a complicated evolutionary process that assigned it many physiological roles.
Massimo Bortolotti +3 more
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The role of urate and xanthine oxidase in vascular oxidative stress:Future directions [PDF]
, 2009 Vascular oxidative stress has been shown to be a potent factor in the pathophysiology of endothelial dysfunction. Despite current optimal evidence-based therapy, mortality from various cardiovascular disorders remains high.
Allan Struthers +3 more
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Ionic Gating of Liquid‐Crystal‐Like Pteridine Assemblies Enables Tunable Light Scattering
Advanced Materials, EarlyView.Tunable optical properties emerge through developmentally regulated ionic gating, which transforms disordered, ultraviolet (UV)‐absorbing organelles into concentrically ordered, liquid‐crystal‐like light scatterers. By integrating analyses of pteridine composition, potassium‐dependent assembly, hierarchical ultrastructure, and optical behavior, the ...
Sourabh Bera +22 more
wiley +1 more source