Results 31 to 40 of about 169,173 (169)

Oxidation of azaheterocycles by free and immobilized xanthine oxidase and xanthine dehydrogenase [PDF]

, 1979
The objective of the study described in this thesis was to show that enzymes, especially immobilized enzymes, can be advantageously used in synthetic organic chemistry.In Chapter 1 enzymes are introduced and the advantages discussed when these highly ...
Tramper, J.
core  

Using Next-Generation Sequencing to Identify a Mutation in Human MCSU that is Responsible for Type II Xanthinuria

Cellular Physiology and Biochemistry, 2015
Background: Hypouricemia is caused by various diseases and disorders, such as hepatic failure, Fanconi renotubular syndrome, nutritional deficiencies and genetic defects.
Yunan Zhou, Xueguang Zhang, Rui Ding, Zuoxiang Li, Quan Hong, Yan Wang, Wei Zheng, Xiaodong Geng, Meng Fan, Guangyan Cai, Xiangmei Chen, Di Wu   +11 more
doaj   +1 more source

Regulation of aging by balancing mitochondrial function and antioxidant levels

Journal of Physiological Sciences, 2022
Aging is the deterioration of physiological mechanisms that is associated with getting old. There is a link between aging and mitochondrial function. However, there is an unresolved relationship between ATP levels and aging.
Sawako Yoshina, Luna Izuhara, Naoyuki Kamatani, Shohei Mitani   +3 more
doaj   +1 more source

Deficiency of GntR Family Regulator MSMEG_5174 Promotes Mycobacterium smegmatis Resistance to Aminoglycosides via Manipulating Purine Metabolism

Frontiers in Microbiology, 2022
The increasing incidence of drug-resistant tuberculosis is still an emergency for global public health and a major obstacle to tuberculosis treatment.
Wanyan Deng, Wanyan Deng, Wanyan Deng, Zengzhang Zheng, Zengzhang Zheng, Yi Chen, Maoyi Yang, Jun Yan, Wu Li, Wu Li, Jie Zeng, Jie Zeng, Jianping Xie, Sitang Gong, Sitang Gong, Huasong Zeng, Huasong Zeng   +16 more
doaj   +1 more source

Ammonification Process Is Limited by Transformation of Medium Molecular Weight Nitrogenous Organics but Not Hydrolysis of Proteins

Advanced Science, EarlyView.
A multi‐level analytical framework, integrating protein‐level persistence analysis, nontargeted HRMS formula tracking, peptide‐level proteomics, and targeted monomer quantification under varying redox conditions, together with FMO calculations reveal that ammonification is limited by medium molecular weight nitrogenous multimers.
Jing Li, Junjie Qiu, Fan Lü, Hua Zhang, Pinjing He   +4 more
wiley   +1 more source

Mitochondria‐Targeting Iron–Carbon Nanozymes Combat Hepatic Ischemia–Reperfusion Injury via the Dual Mechanisms of Respiratory Chain Remodeling and Pyroptosis Inhibition With MRI Monitoring

Advanced Science, EarlyView.
A mitochondrial‐targeted FeCD‐SS31 nanoplatform integrates ROS‐responsive SS31 release with cascade antioxidant Fe3O4/CDs cores to suppress both de novo and existing ROS. By restoring mitochondrial complex integrity and blocking caspase‐1–GSDMD‐N pyroptosis, it reduces neutrophil infiltration and alleviates hepatic ischemia–reperfusion injury, while ...
Qianying Du, Lian Xu, Tingting Xia, Wenli Zhang, Sijin Chen, Xiyue Rong, Ying Luo, Yi Wang, Jia Liu, Yun Liu, Haitao Ran, Dajing Guo, Jie Xu   +12 more
wiley   +1 more source

Xanthine Dehydrogenase Electrocatalysis: Autocatalysis and Novel Activity

, 2016
The enzyme xanthine dehydrogenase (XDH) from the purple photosynthetic bacterium Rhodobacter capsulatus catalyzes the oxidation of hypoxanthine to xanthine and xanthine to uric acid as part of purine metabolism.
Palraj Kalimuthu (1648858), Silke Leimkühler (1327842), Paul V. Bernhardt (1435054)   +2 more
core   +1 more source

Implication of xanthine oxidoreductase in oxidative stress-related chronic diseases

Frontiers in Endocrinology
Xanthine oxidoreductase (XOR) catalyzes the final steps of purine catabolism: the oxidation of hypoxanthine to xanthine, and xanthine to UA. XOR exists as interconvertible proteoforms, xanthine dehydrogenase (XDH) and xanthine oxidase (XO).
Kendra L. Nelson, Kendra L. Nelson, Venkata Saroja Voruganti, Venkata Saroja Voruganti   +3 more
doaj   +1 more source

Gene Location for Molybdenum Cofactor Deficiency

Pediatric Neurology Briefs, 1998
Linkage of a molybdenum cofactor deficiency (MoCoD) gene to an 8-cM region on chromosome 6p21.3 has been localized by homozygosity mapping in 2 consanguineous affected kindreds of Israeli-Arab origin, including 5 patients, at the Department of Genetics ...
J Gordon Millichap
doaj   +1 more source

Germ-Free Conditions Modulate Host Purine Metabolism, Exacerbating Adenine-Induced Kidney Damage

Toxins, 2020
Alterations in microbiota are known to affect kidney disease conditions. We have previously shown that germ-free conditions exacerbated adenine-induced kidney damage in mice; however, the mechanism by which this occurs has not been elucidated. To explore
Eikan Mishima, Mariko Ichijo, Takeshi Kawabe, Koichi Kikuchi, Yukako Akiyama, Takafumi Toyohara, Takehiro Suzuki, Chitose Suzuki, Atsuko Asao, Naoto Ishii, Shinji Fukuda, Takaaki Abe   +11 more
doaj   +1 more source