Uric acid is more strongly associated with impaired glucose regulation in women than in men from the general population: the KORA F4-Study. [PDF]
, 2012 High serum uric acid (UA) levels are associated with the metabolic syndrome, type 2 diabetes and cardiovascular disease. It is largely unknown whether there are gender-specific differences regarding the association between UA and prediabetic states.
Döring, Angela +5 more
core +14 more sources
Rheumatology, 2010 Uric acid (UA) is the end product of purine metabolism in humans due to the loss of uricase activity by various mutations of its gene during the Miocene epoch, which led to humans having higher UA levels than other mammals. Furthermore, 90% of UA filtered by the kidneys is reabsorbed, instead of being excreted.
Bonifacio, Álvarez-Lario +1 more
openaire +2 more sources
Antiepileptic drugs reduce serum uric acid [PDF]
, 1987 Uric acid examination in 554 epileptic out-patients under long-term anticonvulsant medication revealed significantly lower serum concentrations compared to a group of normal controls.
Arab +7 more
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Lesinurad, a novel, oral compound for gout, acts to decrease serum uric acid through inhibition of urate transporters in the kidney. [PDF]
, 2016 BackgroundExcess body burden of uric acid promotes gout. Diminished renal clearance of uric acid causes hyperuricemia in most patients with gout, and the renal urate transporter (URAT)1 is important for regulation of serum uric acid (sUA) levels.
Girardet, Jean-Luc +12 more
core +2 more sources
Uric acid enhances longevity and endurance and protects the brain against ischemia [PDF]
, 2020 Among mammals, there is a positive correlation between serum uric acid (UA) levels and life span. Humans have high levels of UA because they lack a functional urate oxidase (UOX) enzyme that is present in shorter lived mammals.
Argüelles Castilla, Sandro +6 more
core +1 more source
Allopurinol use yields potentially beneficial effects on inflammatory indices in those with recent ischemic stroke: a randomized, double-blind, placebo-controlled trial [PDF]
, 2008 <p><b>Background and Purpose</b>: Elevated serum uric acid level is associated with poor outcome and increased risk of recurrent events after stroke.
Dawson, J. +6 more
core +1 more source
Carbon fibre composites: integrated electrochemical sensors for wound management [PDF]
, 2008 The applicability of employing a carbon fibre mesh as an electrochemical sensing substructure for assessing urate transformations within wound exudates is evaluated.
Abdel-Fattah +43 more
core +1 more source
Uric acid and hypertension: Does uric acid lick the joints and bites the heart? [PDF]
, 2014 Background: Uric acid a metabolic end product of purine degradation is implicated in gout as aetiology. Its increased levels have also been associated with hypertension, cardiovascular morbidity and mortality.
Vittal BG, Bhaskara K, Naveenkumar GH
core +1 more source
Relationship between platelet count and platelet width distribution and serum uric acid 1 concentrations in patients with untreated essential hypertension [PDF]
, 2018 Hematological parameters have emerged as independent determinants of high serum concentrations of uric-acid and predictive-factors in the evaluation of the total cardiovascular-risk in patients with essential-hypertensive.
Avan, Amir +20 more
core +1 more source