Results 41 to 50 of about 126,447 (164)
Rheumatology, 2010 Uric acid (UA) is the end product of purine metabolism in humans due to the loss of uricase activity by various mutations of its gene during the Miocene epoch, which led to humans having higher UA levels than other mammals. Furthermore, 90% of UA filtered by the kidneys is reabsorbed, instead of being excreted.
Bonifacio, Álvarez-Lario +1 more
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Elevated uric acid level decreases glycated hemoglobin in type 2 diabetes mellitus [PDF]
Universa Medicina, 2014 Background Type 2 diabetes mellitus is a heterogeneous disease which is characterized by variable degrees of insulin resistance and impaired insulin secretion.
Muhammad Fahmi Hidayat +2 more
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Biology, 2022 Hyperuricemia is a risk factor for heart disease. Cardiomyocytes produce uric acid via xanthine oxidase. The enzymatic reaction leads to oxidative stress in uric-acid-producing cells.
Martin Weber +2 more
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Progress in research on uric acid metabolism pathway
Linchuang shenzangbing zazhi, 2019 Uric acid is a product of sputum metabolism, and its crease is caused by increase in uric acid production and a decrease in uric acid excretion. The main metabolic pathway of uric acid is present in the kidney, and secondly in the intestine; and the ...
HU Xiao-hua, ZHANG Li-ming
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High uric acid model in Caenorhabditis elegans
Food Science and Human Wellness, 2019 To establish experimental high uric acid model in C. elegans. Hypoxanthine, adenine, xanthine, and uric acid were used to treat C. elegans and then hyperuricemic C. elegans was evaluated by allopurinol. Hyperuricemic C. elegans were obtained after normal
Zhenjing Li +6 more
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Simple and Rapid Method for the Determination of Uric Acid-Independent Antioxidant Capacity
Molecules, 2011 Determination of the relative contribution of uric acid level increases to the total measured antioxidative activity could be very useful for testing antioxidative products and their effect on human health.
Darko Modun +3 more
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Uric Acid Metabolism, Uric Acid Transporters and Dysuricemia
YAKUGAKU ZASSHISerum urate levels are determined by the balance between uric acid production and uric acid excretion capacity from the kidneys and intestinal tract. Dysuricemia, including hyperuricemia and hypouricemia, develops when the balance shifts towards an increase or a decrease in the uric acid pool.
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Establishment of a novel cynomolgus monkey model of hyperuricemia
Animal Models and Experimental MedicineBackground Chronic hyperuricemia is associated with complications such as gout and uric acid nephropathy, but uric acid also exhibits biological activities (e.g., antioxidant effects, potential neuroprotective properties against neurodegenerative ...
Ji‐Wei Wang +12 more
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Uric Acid is independently associated with diabetic kidney disease: a cross-sectional study in a Chinese population. [PDF]
PLoS ONE, 2015 Association between hyperuricaemia and chronic kidney disease has been studied widely, but the influence of uric acid on the kidneys remains controversial.
Dandan Yan +10 more
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