Xanthine oxidoreductase activity is correlated with hepatic steatosis [PDF]
Scientific Reports, 2022 The enzyme xanthine oxidoreductase (XOR) catalyzes the synthesis of uric acid (UA) from hypoxanthine and xanthine, which are products of purine metabolism starting from ribose-5-phosphate.
Chisako Yagi +14 more
doaj +5 more sources
Discriminating Susceptibility of Xanthine Oxidoreductase Family to Metals [PDF]
Microbiology Spectrum, 2023 The xanthine oxidoreductase (XOR) family are metal-containing enzymes that use the molybdenum cofactor (Moco), 2Fe-2S clusters, and flavin adenine dinucleotide (FAD) for their catalytic activity.
Anne-Soisig Steunou +7 more
doaj +6 more sources
Association of Mutations Identified in Xanthinuria with the Function and Inhibition Mechanism of Xanthine Oxidoreductase [PDF]
Biomedicines, 2021 Xanthine oxidoreductase (XOR) is an enzyme that catalyzes the two-step reaction from hypoxanthine to xanthine and from xanthine to uric acid in purine metabolism.
Mai Sekine +2 more
exaly +4 more sources
Xanthine oxidoreductase: One enzyme for multiple physiological tasks [PDF]
Redox Biology, 2021 Human xanthine oxidoreductase (XOR) is a multiple-level regulated enzyme, resulting from a complicated evolutionary process that assigned it many physiological roles.
Massimo Bortolotti +2 more
exaly +4 more sources
Pro-Aging Effects of Xanthine Oxidoreductase Products [PDF]
Antioxidants, 2020 The senescence process is the result of a series of factors that start from the genetic constitution interacting with epigenetic modifications induced by endogenous and environmental causes and that lead to a progressive deterioration at the cellular and
Maria Giulia Battelli +3 more
doaj +6 more sources
Implication of xanthine oxidoreductase in oxidative stress-related chronic diseases [PDF]
Frontiers in EndocrinologyXanthine oxidoreductase (XOR) catalyzes the final steps of purine catabolism: the oxidation of hypoxanthine to xanthine, and xanthine to UA. XOR exists as interconvertible proteoforms, xanthine dehydrogenase (XDH) and xanthine oxidase (XO).
Kendra L. Nelson +3 more
doaj +2 more sources
Xanthine oxidoreductase: A leading actor in cardiovascular disease drama [PDF]
Redox Biology, 2021 Cardiovascular diseases (CVD) are the leading cause of global mortality and their pathogenesis lies mainly in the atherosclerotic process. There are close connections linking oxidative stress and inflammation to endothelial dysfunction, atherosclerosis ...
Letizia Polito +3 more
doaj +2 more sources
A Newly Developed Method-Based Xanthine Oxidoreductase Activities in Various Human Liver Diseases [PDF]
Biomedicines, 2023 Studies evaluating xanthine oxidoreductase (XOR) activities in comprehensive liver diseases are scarce, and different etiologies have previously been combined in groups for comparison.
Ken Sato +13 more
doaj +2 more sources
Xanthine Oxidoreductase: A Double-Edged Sword in Neurological Diseases [PDF]
AntioxidantsNon-communicable neurological disorders are the second leading cause of death, and their burden continues to increase as the world population grows and ages.
Massimo Bortolotti +3 more
doaj +2 more sources
Hemin and iron increase synthesis and trigger export of xanthine oxidoreductase from hepatocytes to the circulation [PDF]
Redox Biology, 2023 We recently reported a previously unknown salutary role for xanthine oxidoreductase (XOR) in intravascular heme overload whereby hepatocellular export of XOR to the circulation was identified as a seminal step in affording protection.
Evan R. DeVallance +12 more
doaj +2 more sources