Xanthine oxidoreductase and xanthine oxidase in human cornea. [PDF]
Histology and histopathology, 2002 Xanthine oxidoreductase (xanthine dehydrogenase + xanthine oxidase) is a complex enzyme that catalyzes the oxidation of hypoxanthine to xanthine, subsequently producing uric acid. The enzyme complex exists in separate but interconvertible forms, xanthine dehydrogenase and xanthine oxidase, which generate reactive oxygen species (ROS), a well known ...
Cejkova, J. +3 more
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The Thermodynamics of Xanthine Oxidoreductase Catalysis [PDF]
Antioxidants & Redox Signaling, 1999 Xanthine oxidoreductase is a complex enzyme found in a wide range of organisms. Recent interest in this enzyme stems from its ability to produce reactive oxygen species under a range of conditions. It is found as a homodimer, each unit containing a molybdopterin cofactor, two iron sulfur centers, and FAD.
Sanders, Stephen A., Massey, Vincent
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Metabolic syndrome and cancer risk: The role of xanthine oxidoreductase [PDF]
Redox Biology, 2019 Obesity and related pathologies such as diabetes and metabolic syndrome are associated with chronic inflammation and cancer. The serum level of xanthine oxidoreductase (XOR) is correlated to obesity-associated metabolic disorders.
Maria Giulia Battelli +3 more
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Emerging Roles of Xanthine Oxidoreductase in Chronic Kidney Disease [PDF]
AntioxidantsXanthine Oxidoreductase (XOR) is a ubiquitous, essential enzyme responsible for the terminal steps of purine catabolism, ultimately producing uric acid that is eliminated by the kidneys.
Hunter W. Korsmo +2 more
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Mechanism of porcine liver xanthine oxidoreductase mediated N-oxide reduction of cyadox as revealed by docking and mutagenesis studies. [PDF]
PLoS ONE, 2013 Xanthine oxidoreductase (XOR) is a cytoplasmic molybdenum-containing oxidoreductase, catalyzing both endogenous purines and exogenous compounds. It is suggested that XOR in porcine hepatocytes catalyzes the N-oxide reduction of quinoxaline 1,4-di-N ...
Chigang Chen +7 more
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Inhibition of xanthine oxidoreductase with febuxostat, but not allopurinol, prevents inflammasome assembly and IL-1β release [PDF]
Life Science AllianceThis study focuses on the underappreciated distinct effects of two clinically used xanthine oxidoreductase inhibitors: allopurinol and febuxostat. Besides reducing uric acid levels in gout treatment, febuxostat, but not allopurinol, prevents NLRP3 ...
Lauar de Brito Monteiro +9 more
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The nitrite reductase activity of xanthine oxidoreductase sustains cardiovascular health as mice age [PDF]
Redox BiologyBackground: Xanthine oxidoreductase (XOR) is a multi-functional enzyme that metabolises purines generating uric acid and generates reactive oxygen species. Both functions have been implicated in the pathogenesis of cardiovascular disease.
Nicki Dyson +14 more
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Xanthine oxidoreductase in cancer: more than a differentiation marker [PDF]
Cancer Medicine, 2015 AbstractHuman xanthine oxidoreductase (XOR) catalyzes the last two steps of purine catabolism and is present in two interconvertible forms, which may utilize O2 or NAD+ as electron acceptors. In addition to uric acid, XOR products may comprise reactive oxygen and nitrogen species that have many biologic effects, including inflammation, endothelial ...
BATTELLI, MARIA GIULIA +3 more
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Tissue xanthine oxidoreductase activity in a mouse model of aristolochic acid nephropathy [PDF]
FEBS Open Bio, 2021 Xanthine oxidoreductase (XOR) is a critical enzyme in purine metabolism and uric acid production, and its levels are reported to increase during stress, thereby promoting organ damage.
Takeo Ishii +13 more
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Purine-Induced IFN-γ Promotes Uric Acid Production by Upregulating Xanthine Oxidoreductase Expression [PDF]
Frontiers in Immunology, 2022 ObjectiveLimiting purine intake, inhibiting xanthine oxidoreductase (XOR) and inhibiting urate reabsorption in proximal tubule by uricosuric drugs, to reduce serum uric acid (UA) levels, are recognized treatments for gout.
Huanhuan Wang +9 more
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