Results 11 to 20 of about 6,803 (119)

Xanthine oxidoreductase activity in platelet-poor and rich plasma as a oxidative stress indicator in patients required renal replacement therapy [PDF]

BMC Nephrology, 2022
Background Xanthine oxidoreductase (XOR) is a hydroxylase enzyme involved in the metabolism of purines. XOR activity can vary: the homodimer protein can be converted into two different isoforms XD (antioxidant) and XO (prooxidant).
Elżbieta Cecerska-Heryć, Rafał Heryć, Grażyna Dutkiewicz, Anna Michalczyk, Bartłomiej Grygorcewicz, Natalia Serwin, Sylwia Napiontek-Balińska, Barbara Dołęgowska   +7 more
doaj   +2 more sources

Emerging Roles of Xanthine Oxidoreductase in Chronic Kidney Disease [PDF]

Antioxidants
Xanthine Oxidoreductase (XOR) is a ubiquitous, essential enzyme responsible for the terminal steps of purine catabolism, ultimately producing uric acid that is eliminated by the kidneys.
Hunter W. Korsmo, Ubong S. Ekperikpe, Ilse S. Daehn   +2 more
doaj   +2 more sources

Inhibition of xanthine oxidoreductase with febuxostat, but not allopurinol, prevents inflammasome assembly and IL-1β release [PDF]

Life Science Alliance
This study focuses on the underappreciated distinct effects of two clinically used xanthine oxidoreductase inhibitors: allopurinol and febuxostat. Besides reducing uric acid levels in gout treatment, febuxostat, but not allopurinol, prevents NLRP3 ...
Lauar de Brito Monteiro, Anne-Sophie Archambault, Lucas F Starchuk, Armando Alcazar, Ju Hee Oh, Joshua A Dubland, Bojana Rakić, Annette E Patterson, C Bruce Verchere, Ramon I Klein Geltink   +9 more
doaj   +2 more sources

The nitrite reductase activity of xanthine oxidoreductase sustains cardiovascular health as mice age [PDF]

Redox Biology
Background: Xanthine oxidoreductase (XOR) is a multi-functional enzyme that metabolises purines generating uric acid and generates reactive oxygen species. Both functions have been implicated in the pathogenesis of cardiovascular disease.
Nicki Dyson, Rayomand S. Khambata, Tipparat Parakaw, Gianmichele Massimo, Ngan HH. Khuat, Annika A. Noor, Lorna C. Gee, Ivy Lim, Umme Siddique, Andrew J. Sullivan, Jonathan W. Ho, Krishnaraj Rathod, Michael R. Barnes, Claudia P. Cabrera, Amrita Ahluwalia   +14 more
doaj   +2 more sources

Purine-Induced IFN-γ Promotes Uric Acid Production by Upregulating Xanthine Oxidoreductase Expression [PDF]

Frontiers in Immunology, 2022
ObjectiveLimiting purine intake, inhibiting xanthine oxidoreductase (XOR) and inhibiting urate reabsorption in proximal tubule by uricosuric drugs, to reduce serum uric acid (UA) levels, are recognized treatments for gout.
Huanhuan Wang, Lingzhu Xie, Xuhong Song, Jing Wang, Xinyan Li, Zhike Lin, Ting Su, Bin Liang, Dongyang Huang, Dongyang Huang   +9 more
doaj   +2 more sources

Tissue xanthine oxidoreductase activity in a mouse model of aristolochic acid nephropathy [PDF]

FEBS Open Bio, 2021
Xanthine oxidoreductase (XOR) is a critical enzyme in purine metabolism and uric acid production, and its levels are reported to increase during stress, thereby promoting organ damage.
Takeo Ishii, Tomohiro Kumagae, Hiromichi Wakui, Shingo Urate, Shohei Tanaka, Eriko Abe, Toru Suzuki, Takahiro Yamaji, Sho Kinguchi, Ryu Kobayashi, Kotaro Haruhara, Takashi Nakamura, Shuzo Kobayashi, Kouichi Tamura   +13 more
doaj   +2 more sources

Xanthine oxidoreductase inhibition ameliorates high glucose-induced glomerular endothelial injury by activating AMPK through the purine salvage pathway [PDF]

Scientific Reports
Xanthine oxidoreductase (XOR) contributes to reactive oxygen species production. We investigated the cytoprotective mechanisms of XOR inhibition against high glucose (HG)-induced glomerular endothelial injury, which involves activation of the AMP ...
Keum-Jin Yang, Hwajin Park, Yoon-Kyung Chang, Cheol Whee Park, Suk Young Kim, Yu Ah Hong   +5 more
doaj   +2 more sources

Computational Characterization of the Inhibition Mechanism of Xanthine Oxidoreductase by Topiroxostat [PDF]

ACS Catalysis, 2023
G Andres Cisneros, Chao Dong, Yazdan Maghsoud   +2 more
exaly   +2 more sources

Inhibitory effects of xanthine oxidase inhibitor, topiroxostat, on development of neuropathy in db/db mice

Neurobiology of Disease, 2021
Inflammation and oxidative stress contribute to the pathophysiology of diabetic neuropathy. According to recent evidence, the modulation of macrophage polarization in peripheral nerves represents a potential therapeutic target for diabetic neuropathy ...
Kazuhisa Takahashi, Hiroki Mizukami, Sho Osonoi, Saori Ogasawara, Yutaro Hara, Kazuhiro Kudoh, Yuki Takeuchi, Takanori Sasaki, Makoto Daimon, Soroku Yagihashi   +9 more
doaj   +1 more source

The Xanthine Oxidase Inhibitor Febuxostat Suppresses Adipogenesis and Activates Nrf2

Antioxidants, 2023
Xanthine oxidoreductase (XOR) is a rate-limiting enzyme in purine catabolism that acts as a novel regulator of adipogenesis. In pathological states, xanthine oxidoreductase activity increases to produce excess reactive oxygen species (ROS).
Yoshiki Higa, Masahiro Hiasa, Hirofumi Tenshin, Emiko Nakaue, Mariko Tanaka, Sooha Kim, Motosumi Nakagawa, So Shimizu, Kotaro Tanimoto, Jumpei Teramachi, Takeshi Harada, Asuka Oda, Masahiro Oura, Kimiko Sogabe, Tomoyo Hara, Ryohei Sumitani, Tomoko Maruhashi, Hiroki Yamagami, Itsuro Endo, Toshio Matsumoto, Eiji Tanaka, Masahiro Abe   +21 more
doaj   +1 more source