Results 31 to 40 of about 38,964 (184)
The Xanthine Oxidase Inhibitor Febuxostat Suppresses Adipogenesis and Activates Nrf2
Antioxidants, 2023 Xanthine oxidoreductase (XOR) is a rate-limiting enzyme in purine catabolism that acts as a novel regulator of adipogenesis. In pathological states, xanthine oxidoreductase activity increases to produce excess reactive oxygen species (ROS).
Yoshiki Higa +21 more
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BMC Nephrology, 2022 Background Xanthine oxidoreductase (XOR) is a hydroxylase enzyme involved in the metabolism of purines. XOR activity can vary: the homodimer protein can be converted into two different isoforms XD (antioxidant) and XO (prooxidant).
Elżbieta Cecerska-Heryć +7 more
doaj +1 more source
The double faced role of xanthine oxidoreductase in cancer. [PDF]
Acta Pharmacol Sin, 2022 Xanthine oxidoreductase (XOR) is a critical, rate-limiting enzyme that controls the last two steps of purine catabolism by converting hypoxanthine to xanthine and xanthine to uric acid. It also produces reactive oxygen species (ROS) during the catalytic process.
Chen MM, Meng LH.
europepmc +3 more sources
Marked elevation in cortical urate and xanthine oxidoreductase activity in experimental bacterial meningitis [PDF]
, 2001 Experimental bacterial meningitis due to Streptococcus pneumoniae in infant rats was associated with a time-dependent increase in CSF and cortical urate that was approximately 30-fold elevated at 22 h after infection compared to baseline.
Christen, Stephan +9 more
core +2 more sources
Shortage of Cellular ATP as a Cause of Diseases and Strategies to Enhance ATP
Frontiers in Pharmacology, 2019 Germline mutations in cellular-energy associated genes have been shown to lead to various monogenic disorders. Notably, mitochondrial disorders often impact skeletal muscle, brain, liver, heart, and kidneys, which are the body’s top energy-consuming ...
Todd A. Johnson +2 more
doaj +1 more source
Role of Xanthine Oxidoreductase as an Antimicrobial Agent [PDF]
Infection and Immunity, 2004 Xanthine oxidoreductase (XOR) is widely distributed in mammalian tissues and has long been known to be a major constituent of the milk fat globule membrane (MFGM), which surrounds fat globules in cow's milk ([36][1], [50][2]).
Hannah M, Martin +3 more
openaire +2 more sources
Role of urate, xanthine oxidase and the effects of allopurinol in vascular oxidative stress [PDF]
, 2009 Oxidative stress plays an important role in the progression of vascular endothelial dysfunction. The two major systems generating vascular oxidative stress are the NADPH oxidase and the xanthine oxidase pathways. Allopurinol, a xanthine oxidase inhibitor,
Struthers, Allan D. +2 more
core +1 more source
The Effects of Xanthine Oxidoreductase Inhibitors on Oxidative Stress Markers following Global Brain Ischemia Reperfusion Injury in C57BL/6 Mice. [PDF]
PLoS ONE, 2015 We demonstrated that 3-nitrotyrosine and 4-hydroxy-2-nonenal levels in mouse brain were elevated from 1 h until 8 h after global brain ischemia for 14 min induced with the 3-vessel occlusion model; this result indicates that ischemia reperfusion injury ...
Masahiro Yamaguchi +6 more
doaj +1 more source
Redox Biology, 2018 Nitric oxide radical (NO) is a signaling molecule involved in several physiological and pathological processes and a new nitrate-nitrite-NO pathway has emerged as a physiological alternative to the ''classic'' pathway of NO formation from L-arginine ...
Luisa B. Maia, José J.G. Moura
doaj +1 more source
Oxidative stress in the pathogenesis of type 1 diabetes: the role of adipocyte xanthine oxidase
Бюллетень сибирской медицины, 2018 Rationale. According to modern understanding, oxidative stress plays an essential role in the underlying mechanisms for the emergence of type 1 and type 2 diabetes and development of complications in these conditions.
V. V. Ivanov +7 more
doaj +1 more source