Results 31 to 40 of about 77,092 (210)

Investigation of the Inhibition Mechanism of Xanthine Oxidoreductase by Oxipurinol: A Computational Study. [PDF]

J Chem Inf Model, 2023
Xanthine oxidoreductase (XOR) is an enzyme found in various organisms. It converts hypoxanthine to xanthine and urate, which are crucial steps in purine elimination in humans.
Maghsoud Y, Dong C, Cisneros GA.
europepmc   +2 more sources

Human Plasma Xanthine Oxidoreductase Activity in Cardiovascular Disease: Evidence from a Population-Based Study. [PDF]

Biomedicines, 2023
Xanthine oxidoreductase (XOR) and its products contribute to the development of chronic inflammation and oxidative stress. Excessive XOR activity is believed to promote inflammatory responses and atherosclerotic plaque formation, which are major ...
Kotozaki Y, Satoh M, Nasu T, Tanno K, Tanaka F, Sasaki M.   +5 more
europepmc   +2 more sources

Xanthine oxidoreductase gene polymorphisms are associated with high risk of sepsis and organ failure. [PDF]

Respir Res, 2023
Background Sepsis and associated organ failures confer substantial morbidity and mortality. Xanthine oxidoreductase (XOR) is implicated in the development of tissue oxidative damage in a wide variety of respiratory and cardiovascular disorders including ...
Gao L, Rafaels N, Dudenkov TM, Damarla M, Damico R, Maloney JP, Moss M, Martin GS, Sevransky J, Shanholtz C, Herr DL, Garcia JGN, Hernandez-Beeftink T, Villar J, Flores C, Beaty TH, Brower R, Hassoun PM, Barnes KC.   +18 more
europepmc   +2 more sources

Comprehensive analysis of the relationship between xanthine oxidoreductase activity and chronic kidney disease. [PDF]

iScience, 2023
Summary Chronic kidney disease (CKD) is a common disease that seriously endangers human health. However, the potential relationship between xanthine oxidoreductase (XOR) activity and CKD remains unclear. In this study, we used clinical data, CKD datasets
Zhang Y, Ding X, Guo L, Zhong Y, Xie J, Xu Y, Li H, Zheng D.   +7 more
europepmc   +2 more sources

Natural mutations of human XDH promote the nitrite (NO₂^-)-reductase capacity of xanthine oxidoreductase: A novel mechanism to promote redox health? [PDF]

Redox Biol, 2023
Several rare genetic variations of human XDH have been shown to alter xanthine oxidoreductase (XOR) activity leading to impaired purine catabolism. However, XOR is a multi-functional enzyme that depending upon the environmental conditions also expresses ...
Massimo G, Khambata RS, Chapman T, Birchall K, Raimondi C, Shabbir A, Dyson N, Rathod KS, Borghi C, Ahluwalia A.   +9 more
europepmc   +2 more sources

A critical role for gastric xanthine oxidoreductase in the formation of S-nitrosothiols and blood pressure responses to nitrite in rats. [PDF]

Redox Biol
Nitrite and nitrate bioactivation to nitric oxide (NO) in the enterosalivary cycle of nitrate offers an enormous therapeutic potential for cardiovascular and metabolic diseases and involves xanthine oxidoreductase (XOR), an enzyme widely expressed in the
de Azevedo Medeiros CF, Neto-Neves EM, Santana IV, Sanches-Lopes JM, Nogueira RC, Batista RIM, Conde-Tella SO, Montenegro MF, Tanus-Santos JE.   +8 more
europepmc   +2 more sources

Allopurinol, Febuxostat, and Nonuse of Xanthine Oxidoreductase Inhibitor Treatment in Patients Receiving Hemodialysis: A Longitudinal Analysis. [PDF]

Kidney Med
Rationale & Objective Allopurinol and febuxostat, which are xanthine oxidoreductase inhibitors, have been widely used as uric acid-lowering medications. However, evidence regarding their cardiovascular effects in hemodialysis is insufficient.
Ishii T, Seya N, Taguri M, Wakui H, Yoshimura A, Tamura K.   +5 more
europepmc   +2 more sources

Xanthine oxidoreductase in atherosclerosis pathogenesis: Not only oxidative stress [PDF]

Atherosclerosis, 2014
Endothelial xanthine oxidoreductase (XOR) together with NAD(P)H oxidase and nitric oxide (NO) synthase plays a physiologic role in inflammatory signalling, the regulation of NO production and vascular function. The oxidative stress generated by these enzymes may induce endothelial dysfunction, leading to atherosclerosis, cardiovascular diseases and ...
BATTELLI, MARIA GIULIA, POLITO, LETIZIA, BOLOGNESI, ANDREA   +2 more
openaire   +5 more sources

The Role of Oxidative Stress in Hyperuricemia and Xanthine Oxidoreductase (XOR) Inhibitors. [PDF]

Oxid Med Cell Longev, 2021
Uric acid is the end product of purine metabolism in humans. Hyperuricemia is a metabolic disease caused by the increased formation or reduced excretion of serum uric acid (SUA).
Liu N, Xu H, Sun Q, Yu X, Chen W, Wei H, Jiang J, Xu Y, Lu W.   +8 more
europepmc   +2 more sources

Association of xanthine oxidoreductase inhibitor use with insulin secretory capacity in patients with type 2 diabetes. [PDF]

J Diabetes Investig
Xanthine oxidoreductase (XOR) inhibitor treatment, which reduces reactive oxygen species (ROS) production and increases adenosine triphosphate (ATP) synthesis, has been reported to improve glycemic control.
Kitamura A, Kurajoh M, Miki Y, Kakutani Y, Yamazaki Y, Ochi A, Morioka T, Mori K, Shoji T, Emoto M.   +9 more
europepmc   +2 more sources