Gender Differences in the Impact of Plasma Xanthine Oxidoreductase Activity on Coronary Artery Spasm. [PDF]
J Clin Med, 2021 Xanthine oxidoreductase (XOR) is the rate-limiting enzyme in uric acid (UA) production that plays a pivotal role in generating oxidative stress. Gender differences in the impact of plasma XOR activity on coronary artery spasm (CAS) remain unclear.
Watanabe K +10 more
europepmc +2 more sources
The Effects of Xanthine Oxidoreductase Inhibitors on Oxidative Stress Markers following Global Brain Ischemia Reperfusion Injury in C57BL/6 Mice. [PDF]
PLoS ONE, 2015 We demonstrated that 3-nitrotyrosine and 4-hydroxy-2-nonenal levels in mouse brain were elevated from 1 h until 8 h after global brain ischemia for 14 min induced with the 3-vessel occlusion model; this result indicates that ischemia reperfusion injury ...
Masahiro Yamaguchi +6 more
doaj +1 more source
Endocrine journal, 2023 Visceral fat-based metabolic syndrome has a strong impact on atherosclerotic cardiovascular disease (CVD), clustering diabetes, dyslipidemia, hypertension, hyperuricemia, and non-alcoholic fatty liver disease (NAFLD).
Y. Fujishima +4 more
semanticscholar +1 more source
Mechanism of porcine liver xanthine oxidoreductase mediated N-oxide reduction of cyadox as revealed by docking and mutagenesis studies. [PDF]
PLoS ONE, 2013 Xanthine oxidoreductase (XOR) is a cytoplasmic molybdenum-containing oxidoreductase, catalyzing both endogenous purines and exogenous compounds. It is suggested that XOR in porcine hepatocytes catalyzes the N-oxide reduction of quinoxaline 1,4-di-N ...
Chigang Chen +7 more
doaj +1 more source
Chronic kidney disease: which role for xanthine oxidoreductase activity and products?
Pharmacological Research, 2022 The present review explores the role of xanthine oxidoreductase (XOR) in the development and progression of chronic kidney disease (CKD). Human XOR is a multi-level regulated enzyme, which has many physiological functions, but that is also implicated in ...
L. Polito +3 more
semanticscholar +1 more source
Oxidative stress in the pathogenesis of type 1 diabetes: the role of adipocyte xanthine oxidase
Бюллетень сибирской медицины, 2018 Rationale. According to modern understanding, oxidative stress plays an essential role in the underlying mechanisms for the emergence of type 1 and type 2 diabetes and development of complications in these conditions.
V. V. Ivanov +7 more
doaj +1 more source
Redox Biology, 2018 Nitric oxide radical (NO) is a signaling molecule involved in several physiological and pathological processes and a new nitrate-nitrite-NO pathway has emerged as a physiological alternative to the ''classic'' pathway of NO formation from L-arginine ...
Luisa B. Maia, José J.G. Moura
doaj +1 more source
Dose-dependent effects of Allopurinol on human foreskin fibroblast cell and human umbilical vein endothelial cell under hypoxia [PDF]
, 2015 Allopurinol, an inhibitor of xanthine oxidase, has been used in clinical trials of patients with cardiovascular and chronic kidney disease. These are two pathologies with extensive links to hypoxia and activation of the transcription factor hypoxia ...
Sun, Yu +8 more
core +1 more source
Advances in Redox Research, 2023 Human xanthine oxidoreductase (XOR) is a multilevel regulated enzyme, which has many physiological functions, but which is also involved in several pathological processes.
Maria Giulia Battelli +3 more
doaj +1 more source
Influence of xanthine oxidoreductase inhibitor, topiroxostat, on body weight of diabetic obese mice. [PDF]
Nutr Diabetes, 2021 Plasma xanthine oxidoreductase (XOR) activity is high in metabolic disorders such as diabetic mellitus, obesity, or overweight. Thus, this study investigated whether the XOR inhibitor, topiroxostat, affected body weight. Male db/db mice were fed standard
Nakamura T +6 more
europepmc +2 more sources