Results 51 to 60 of about 38,964 (184)

A new route to peroxynitrite: a role for xanthine oxidoreductase [PDF]

FEBS Letters, 2000
Peroxynitrite, a potent oxidising, nitrating and hydroxylating agent, results from the reaction of nitric oxide with superoxide. We show that peroxynitrite can be produced by the action of a single enzyme, xanthine oxidoreductase (XOR), in the presence of inorganic nitrite, molecular oxygen and a reducing agent, such as pterin.
Godber, Ben L.J, Doel, Justin J, Durgan, Joanne, Eisenthal, Robert, Harrison, Roger   +4 more
openaire   +2 more sources

Effects of catechins, resveratrol, silymarin components and some of their conjugates on xanthine oxidase‐catalyzed xanthine and 6‐mercaptopurine oxidation

Journal of the Science of Food and Agriculture, Volume 105, Issue 5, Page 2765-2776, 30 March 2025.
Abstract BACKGROUND Over the past two decades, the global incidence of gout has markedly increased, affecting people worldwide. Considering the side effects of xanthine oxidase (XO) inhibitor drugs (e.g. allopurinol and febuxostat) used in the treatment of hyperuricemia and gout, the potential application of phytochemicals has been widely studied.
Tímea Bencsik, Orsolya Balázs, Róbert G Vida, Balázs Z Zsidó, Csaba Hetényi, Kateřina Valentová, Miklós Poór   +6 more
wiley   +1 more source

Oxaziridines: Versatile Reagents in Modern Organic Synthesis

The Chemical Record, EarlyView.
Being capable of transferring an O atom and N‐group/atom, oxaziridines are considered multitasking agents. These are employed for diverse organic transformations, such as epoxidation of olefins, α‐ and γ‐hydroxylation/amination of carbonyl compounds, oxidation of sulfides, [3+2]cycloaddition with unsaturated systems.
Ajeet Chandra, Subba Rao Cheekatla, Keshaba Nanda Parida   +2 more
wiley   +1 more source

Xanthine Oxidoreductase Is an Endogenous Regulator of Cyclooxygenase-2 [PDF]

Circulation Research, 2004
Xanthine oxidoreductase (XOR) is the enzyme responsible for the final step in purine degradation resulting in the generation of uric acid. Here we have generated mice deficient in XOR. As expected, these animals lack tissue XOR activity and have low to undetectable serum levels of uric acid. Although normal at birth, XOR−/− mice fail to thrive after 10
Toshio, Ohtsubo, Ilsa I, Rovira, Matthew F, Starost, Chengyu, Liu, Toren, Finkel   +4 more
openaire   +2 more sources

Crystal Structures of Urate Bound Form of Xanthine Oxidoreductase: Substrate Orientation and Structure of the Key Reaction Intermediate

, 2016
Two contradictory models have been proposed for the binding mode of the substrate xanthine to and its activation mechanism by xanthine oxidoreductase. In an effort to distinguish between the two models, we determined the crystal structures of the urate ...
Ken Okamoto (778187), Yuko Kawaguchi (2245831), Emil F. Pai (411935), Takeshi Nishino (2122573), Bryan T. Eger (2122570)   +4 more
core   +1 more source

Non‐canonical PKG1 regulation in cardiovascular health and disease

British Journal of Pharmacology, EarlyView.
It is well established that the cyclic GMP‐dependent protein kinase I (PKG1) is canonically activated by cyclic guanosine monophosphate (cGMP), enabling its regulation of vascular tone, cardiac function and smooth muscle homeostasis. However, diverse non‐canonical stimuli of PKG1 have also been identified.
Jie Su, Joseph Robert Burgoyne
wiley   +1 more source

Plasma Xanthine Oxidoreductase Activity Associated with Glycemic Control in Patients with Pre-Dialysis Chronic Kidney Disease

Kidney & Blood Pressure Research, 2021
Introduction: Xanthine oxidoreductase (XOR) activity plays an important role as a pivotal source of reactive oxygen species, which is associated with cardiovascular disease (CVD) events. Patients with CKD have increased risk of CVD events. In the present
Shinya Nakatani, Eiji Ishimura, Takayo Murase, Takashi Nakamura, Ayumi Nakatani, Norikazu Toi, Kozo Nishide, Hideki Uedono, Akihiro Tsuda, Masafumi Kurajoh, Shinsuke Yamada, Katsuhito Mori, Masaaki Inaba, Masanori Emoto   +13 more
doaj   +1 more source

Transgenic selection and underlying mechanisms in apicomplexan parasites

The FEBS Journal, EarlyView.
Transgenic selection markers have driven genetic engineering in apicomplexans, enabling precise, iterative experiments. This review discusses mechanistic details of drug selection markers, strategies for marker recycling, and practical considerations for several clinically relevant parasites.
Swaroop Peddiraju, Rakhee Lohia, Nishith Gupta   +2 more
wiley   +1 more source

Pretreatment of keratinocytes with Galactomyces ferment filtrate (GFF) promotes stress resiliency in an in vitro oxidative stress model

International Journal of Cosmetic Science, EarlyView.
GFF pretreatment enhances keratinocyte protection against oxidative stress by mitigating stress‐induced biomolecular changes and gene expression dysregulation. GFF‐pretreated keratinocytes maintain healthy epidermal biology post‐stress, preserving mitochondrial function and proliferative capacity.
Lisa C. Green, Tim Reichling, Holly A. Rovito, Jodie Reed, Xingtao Wei, John M. Snowball, Tom Cambron, Tomohiro Hakozaki   +7 more
wiley   +1 more source

Effects of cold water immersion versus active recovery on oxidative stress, redox gene expression and mitochondrial adaptations after strength training

Experimental Physiology, EarlyView.
Abstract We compared the acute and chronic effects of postexercise cold water immersion (CWI) and active recovery (ACT) on oxidative stress, redox‐related gene expression, mitochondrial adaptations and muscle oxidative capacity. In a crossover study, nine males completed strength sessions, followed by either 10 min CWI or ACT.
Llion A. Roberts, Chantal A. Pileggi, Nina Zeng, Vandre C. Figueiredo, James F. Markworth, Truls Raastad, David Briskey, Katsuhiko Suzuki, Jeff S. Coombes, David Cameron‐Smith, Jonathan M. Peake   +10 more
wiley   +1 more source