Results 61 to 70 of about 6,803 (119)

Clinical Implications and Research Progress of Salivary Biomarkers for Endocrine and Metabolic Disorders

Diabetes, Obesity and Metabolism, Volume 28, Issue 8, Page 6561-6575, August 2026.
ABSTRACT Aims Similar to blood, saliva contains a broad range of biomarkers and may offer a non‐invasive, repeatable specimen for endocrine and metabolic assessment. This review aims to synthesise and evaluate recent advances in the clinical translation of salivary biomarkers, while providing a critical assessment of the diagnostic reliability and ...
Chuyan Yu, Jiaying Ni, Qian Dou, Hang Su, Ziyi Zhang, Xiaojing Ma, Qing Dai, Jian Zhou   +7 more
wiley   +1 more source

Omeprazole impairs vascular redox biology and causes xanthine oxidoreductase-mediated endothelial dysfunction

Redox Biology, 2016
Proton pump inhibitors (PPIs) are widely used drugs that may increase the cardiovascular risk by mechanisms not entirely known. While PPIs increase asymmetric dimethylarginine (ADMA) levels and inhibit nitric oxide production, it is unknown whether ...
Lucas C. Pinheiro, Gustavo H. Oliveira-Paula, Rafael L. Portella, Danielle A. Guimarães, Celio D. de Angelis, Jose E. Tanus-Santos   +5 more
doaj   +1 more source

Mitochondrial oxidative stress, calcium and dynamics in cardiac ischaemia‐reperfusion injury

The Journal of Physiology, Volume 604, Issue 16, Page 6659-6674, 15 August 2026.
Abstract figure legend Heart attack causes ischaemia–reperfusion injury in cardiomyocytes. Mitochondria generate reactive oxygen species (ROS), leading to oxidative stress. High levels of mitochondrial calcium (Ca2+) activate the mitochondrial permeability transition pore (mPTP), and excess ROS levels can lower the Ca2+ required to activate the mPTP ...
Emily Rozich, Ulas Ozkurede, Shanmugasundaram Pakkiriswami, Ryan Gemilere, Samira M. Azarin, Julia C. Liu   +5 more
wiley   +1 more source

Relationship between xanthine oxidoreductase and renal damage in chronic kidney disease patients

Linchuang shenzangbing zazhi, 2020
Objective To explore the relationship between xanthine oxidoreductase(XOR)activity and kidney injury in patients with chronic kidney disease(CKD).Methods A total of 105 patients with CKD were selected as the research objects in this study.We measured ...
ZHANG Yi-yuan, ZHAO Ming-yue, WEI Juan-yu, ZHANG Shuai, XU Meng, ZHENG Dong-hui   +5 more
doaj  

Relationship between plasma xanthine oxidoreductase activity and left ventricular ejection fraction and hypertrophy among cardiac patients.

PLoS ONE, 2017
Background and purposeXanthine oxidoreductase (XOR), which catalyzes purine catabolism, has two interconvertible forms, xanthine dehydrogenase and xanthine oxidase, the latter of which produces superoxide during uric acid (UA) synthesis.
Yuki Fujimura, Yohei Yamauchi, Takayo Murase, Takashi Nakamura, Shu-Ichi Fujita, Tomohiro Fujisaka, Takahide Ito, Koichi Sohmiya, Masaaki Hoshiga, Nobukazu Ishizaka   +9 more
doaj   +1 more source

Disrupted NAD(P) Metabolism and Xanthine Dehydrogenase in a Stress-Induced Rat Model of Depression: NMR Metabolomics Insights

Metabolites
Background: Clinical findings have shown a negative correlation between the severity of depressive symptoms and serum uric acid levels in men, yet the role of metabolic regulation in the pathophysiology of depression remains largely unknown.
Songjiao Chen, Jumeng Wei, Yongchi Wang, Yidan Yao, Haibo Wang, Jie Peng, Jinquan Li   +6 more
doaj   +1 more source

Allopurinol and oxypurinol differ in their strength and mechanisms of inhibition of xanthine oxidoreductase. [PDF]

J Biol Chem, 2023
Sekine M, Okamoto K, Pai EF, Nagata K, Ichida K, Hille R, Nishino T.   +6 more
europepmc   +1 more source

Comparative characteristics of blood xanthine oxidoreductase profiles in discoid and systemic lupus erythematosus

Сибирский научный медицинский журнал
Discoid (DLE) and systemic lupus erythematosus (SLE) are chronic inflammatory diseases of the connective tissue. Along with pathogenetic features, they have common characteristics. Immune disorders and oxidative stress are involved in pathogenesis of DLE
E. E. Mozgovaya, S. A. Bedina, A. S. Trofimenko, S. S. Spitsina, M. A. Mamus, I. A. Zborovskaya   +5 more
doaj   +1 more source

Investigation of the Inhibition Mechanism of Xanthine Oxidoreductase by Oxipurinol: A Computational Study. [PDF]

J Chem Inf Model, 2023
Maghsoud Y, Dong C, Cisneros GA.
europepmc   +1 more source

Asymmetric nanozymes improve cardiac purine catabolism and alleviate oxidative stress of myocardium to treat ischemic heart disease

Journal of Nanobiotechnology
Ischemic heart disease (IHD) refers to a condition with myocardial ischemia, hypoxia, and even cardiomyocyte death due to coronary artery stenosis or occlusion.
Yun Jiang, Hang Chen, Wei Chen, Liyun Zhu, Xiya Wang, Pingyuan Sun, Chanyuan Su, Renxiang Gui, Huiying Yang, Tao Yue, Kunpeng Wang, Pengyu Yang, Lizhi Dou, Linlin Zhao, Emeli Chatterjee, Guoping Li, Xuerui Chen, Jianle Chen   +17 more
doaj   +1 more source