Results 61 to 70 of about 77,092 (210)

Association of the plasma xanthine oxidoreductase activity with the metabolic parameters and vascular complications in patients with type 2 diabetes

Scientific Reports, 2021
Xanthine oxidoreductase (XOR) catalyzes the oxidation of hypoxanthine to xanthine, and of xanthine to uric acid. XOR also enhances the production of reactive oxygen species and causes endothelial dysfunction.
Tomoko Okuyama, Jun Shirakawa, Takashi Nakamura, Takayo Murase, Daisuke Miyashita, Ryota Inoue, Mayu Kyohara, Yu Togashi, Yasuo Terauchi   +8 more
doaj   +1 more source

Differential regulation of hypoxanthine and xanthine by obesity in a general population

Journal of Diabetes Investigation, 2020
Aims/Introduction Uric acid is synthesized by oxidation of hypoxanthine and xanthine using a catalyzing enzyme, xanthine oxidoreductase (XOR), which can be a source of reactive oxygen species.
Masato Furuhashi, Masayuki Koyama, Yukimura Higashiura, Takayo Murase, Takashi Nakamura, Megumi Matsumoto, Akiko Sakai, Hirofumi Ohnishi, Marenao Tanaka, Shigeyuki Saitoh, Norihito Moniwa, Kazuaki Shimamoto, Tetsuji Miura   +12 more
doaj   +1 more source

Comparative effects of topiroxostat and febuxostat on arterial properties in hypertensive patients with hyperuricemia

The Journal of Clinical Hypertension, 2021
Elevated serum uric acid is a cardiovascular risk factor in patients with hypertension, even when blood pressure (BP) is well controlled. Xanthine oxidoreductase inhibitors (XORi) reduce serum uric acid levels and have several other potential effects ...
Kazuomi Kario, Masafumi Nishizawa, Mari Kiuchi, Arihiro Kiyosue, Fumishi Tomita, Hiroshi Ohtani, Yasuhisa Abe, Hideyo Kuga, Satoshi Miyazaki, Takatoshi Kasai, Makiko Hongou, Takanori Yasu, Jin Kuramochi, Yoshihiro Fukumoto, Satoshi Hoshide, Ichiro Hisatome   +15 more
doaj   +1 more source

Xanthine oxidoreductase inhibition – A review of computational aspect

, 2020
Xanthine Oxidoreductase (XOR) exists in a variety of organisms from bacteria to humans and catalyzes the oxidation of hypoxanthine to xanthine and from xanthine to uric acid. Excessive uric acid could lead to gout and hyperuricemia.
Montes, Milka O., Dong, Chao, Al-Sawai, Wael M.   +2 more
core   +1 more source

Quantitative in situ analysis of xanthine oxidoreductase activity in rat liver. [PDF]

, 1995
The tetrazolium salt method previously developed for the detection of xanthine oxidoreductase activity in unfixed cryostat sections has been validated for quantitative purposes.
K S Bosch, W M Frederiks, A Kooij
core   +1 more source

Some opportunities of using xanthine oxidase inhibitors

Современная ревматология, 2019
The review presents modern concepts of the role of xanthine oxidase (XO) in the pathogenesis of a number of diseases. It has been shown that XO activity can be associated with the development and progression not only of gout, but, possibly, diabetes ...
O. V. Zhelyabina, M. S. Eliseev
doaj   +1 more source

Xanthine Oxidoreductase Inhibitors Suppress the Onset of Exercise-Induced AKI in High HPRT Activity Urat1-Uox Double Knockout Mice

Journal of the American Society of Nephrology, 2021
Significance Statement Hereditary renal hypouricemia type 1 (RHUC1) is caused by URAT1/SLC22A12 dysfunction, resulting in urolithiasis and exercise-induced AKI (EIAKI).
T. Hosoya, S. Uchida, S. Shibata, N. H. Tomioka, Koji Matsumoto, M. Hosoyamada   +5 more
semanticscholar   +1 more source

Marked elevation in cortical urate and xanthine oxidoreductase activity in experimental bacterial meningitis

, 2001
Experimental bacterial meningitis due to Streptococcus pneumoniae in infant rats was associated with a time-dependent increase in CSF and cortical urate that was approximately 30-fold elevated at 22 h after infection compared to baseline.
Christen, Stephan, Täuber, Martin G., Leib, Stephen L., Bifrare, Yeong-Delphine, Siegenthaler, Corinne   +4 more
core   +1 more source

Computational Characterization of the Inhibition Mechanism of Xanthine Oxidoreductase by Topiroxostat

, 2022
Xanthine oxidase (XO) is a member of the molybdopterin-containing enzyme family. It interconverts xanthine to uric acid as the last step of purine catabolism in the human body.
G. Andrés, Cisneros, Yazdan, Maghsoud, Chao, Dong   +2 more
core   +1 more source

Research advances in the therapeutic potential of xanthine oxidoreductase inhibitors for periodontitis

口腔疾病防治, 2023
Periodontitis is associated with abnormal purine metabolism, which is manifested by increased uric acid in host blood and increased expression of the purine-degrading enzyme, xanthine oxidoreductase (XOR), in periodontal tissues.
LI Yongshan , WU Zhicong, WANG Zixing, YU Xihuang, LIU Xi, YU Ting   +5 more
doaj   +1 more source