Results 41 to 50 of about 38,964 (184)
Scientific Reports, 2021 Xanthine oxidoreductase (XOR) catalyzes the oxidation of hypoxanthine to xanthine, and of xanthine to uric acid. XOR also enhances the production of reactive oxygen species and causes endothelial dysfunction.
Tomoko Okuyama +8 more
doaj +1 more source
Phenolics Contents, Xanthine Oxidoreductase Inhibitory Potential, Antibacterial and Antioxidant Activities of Cachrys libanotis L. Root Extracts [PDF]
, 2020 To date, no studies have investigated the phytochemical screening and biological activities of Cachrys libanotis L. traditionally used for the treatment of gout and rheumatism.
Trabsa, Hayat +5 more
core +1 more source
Differential regulation of hypoxanthine and xanthine by obesity in a general population
Journal of Diabetes Investigation, 2020 Aims/Introduction Uric acid is synthesized by oxidation of hypoxanthine and xanthine using a catalyzing enzyme, xanthine oxidoreductase (XOR), which can be a source of reactive oxygen species.
Masato Furuhashi +12 more
doaj +1 more source
Xanthine oxidoreductase inhibition – A review of computational aspect
, 2020 Xanthine Oxidoreductase (XOR) exists in a variety of organisms from bacteria to humans and catalyzes the oxidation of hypoxanthine to xanthine and from xanthine to uric acid. Excessive uric acid could lead to gout and hyperuricemia.
Montes, Milka O. +2 more
core +1 more source
Xanthine Oxidoreductase Is a Regulator of Adipogenesis and PPARγ Activity [PDF]
Cell Metabolism, 2007 In an effort to identify novel candidate regulators of adipogenesis, gene profiling of differentiating 3T3-L1 preadipocytes was analyzed using a novel algorithm. We report here the characterization of xanthine oxidoreductase (XOR) as a novel regulator of adipogenesis. XOR lies downstream of C/EBPbeta and upstream of PPARgamma, in the cascade of factors
Cheung, Kevin J. +9 more
openaire +2 more sources
Some opportunities of using xanthine oxidase inhibitors
Современная ревматология, 2019 The review presents modern concepts of the role of xanthine oxidase (XO) in the pathogenesis of a number of diseases. It has been shown that XO activity can be associated with the development and progression not only of gout, but, possibly, diabetes ...
O. V. Zhelyabina, M. S. Eliseev
doaj +1 more source
The Journal of Clinical Hypertension, 2021 Elevated serum uric acid is a cardiovascular risk factor in patients with hypertension, even when blood pressure (BP) is well controlled. Xanthine oxidoreductase inhibitors (XORi) reduce serum uric acid levels and have several other potential effects ...
Kazuomi Kario +15 more
doaj +1 more source
Quantitative in situ analysis of xanthine oxidoreductase activity in rat liver. [PDF]
, 1995 The tetrazolium salt method previously developed for the detection of xanthine oxidoreductase activity in unfixed cryostat sections has been validated for quantitative purposes.
K S Bosch, W M Frederiks, A Kooij
core +1 more source
口腔疾病防治, 2023 Periodontitis is associated with abnormal purine metabolism, which is manifested by increased uric acid in host blood and increased expression of the purine-degrading enzyme, xanthine oxidoreductase (XOR), in periodontal tissues.
LI Yongshan +5 more
doaj +1 more source
Vaginal host–microbe signatures linked to placental outcomes in mares
Equine Veterinary Journal, EarlyView.Abstract Background Ascending placentitis is a leading cause of late‐term pregnancy loss in mares. Although pathogens are presumed to ascend from the caudal reproductive tract, the association between the vaginal microbiome and placentitis has not been systematically examined.
Machteld van Heule +7 more
wiley +1 more source