Results 41 to 50 of about 77,092 (210)

Possible Use of Non-purine Selective Xanthine Oxidoreductase Inhibitors for Prevention of Exercise-induced Acute Kidney Injury Associated with Renal Hypouricemia. [PDF]

Intern Med, 2023
Exercise-induced acute kidney injury (EIAKI) is frequently complicated with renal hypouricemia (RHUC). In patients with RHUC, limiting anaerobic exercise can prevent EIAKI. However, it is challenging to reduce exercise intensity in athletes.
Aizawa C, Okabe M, Takahashi D, Sagasaki M, Watanabe M, Fujimoto T, Yoshioka Y, Katsuma A, Kimura A, Miyamoto D, Sato N, Okamoto K, Ichida K, Miyazaki Y, Yokoo T.   +14 more
europepmc   +2 more sources

Inhibitory effects of xanthine oxidase inhibitor, topiroxostat, on development of neuropathy in db/db mice

Neurobiology of Disease, 2021
Inflammation and oxidative stress contribute to the pathophysiology of diabetic neuropathy. According to recent evidence, the modulation of macrophage polarization in peripheral nerves represents a potential therapeutic target for diabetic neuropathy ...
Kazuhisa Takahashi, Hiroki Mizukami, Sho Osonoi, Saori Ogasawara, Yutaro Hara, Kazuhiro Kudoh, Yuki Takeuchi, Takanori Sasaki, Makoto Daimon, Soroku Yagihashi   +9 more
doaj   +1 more source

The Xanthine Oxidase Inhibitor Febuxostat Suppresses Adipogenesis and Activates Nrf2

Antioxidants, 2023
Xanthine oxidoreductase (XOR) is a rate-limiting enzyme in purine catabolism that acts as a novel regulator of adipogenesis. In pathological states, xanthine oxidoreductase activity increases to produce excess reactive oxygen species (ROS).
Yoshiki Higa, Masahiro Hiasa, Hirofumi Tenshin, Emiko Nakaue, Mariko Tanaka, Sooha Kim, Motosumi Nakagawa, So Shimizu, Kotaro Tanimoto, Jumpei Teramachi, Takeshi Harada, Asuka Oda, Masahiro Oura, Kimiko Sogabe, Tomoyo Hara, Ryohei Sumitani, Tomoko Maruhashi, Hiroki Yamagami, Itsuro Endo, Toshio Matsumoto, Eiji Tanaka, Masahiro Abe   +21 more
doaj   +1 more source

Possible role of insulin resistance in activation of plasma xanthine oxidoreductase in health check-up examinees. [PDF]

Sci Rep, 2022
We previously found an association of insulin resistance (IR) with plasma xanthine oxidoreductase (XOR) activity in a cross-sectional study. However, whether IR induces increased XOR activity has not been elucidated.
Kurajoh M, Fukumoto S, Akari S, Murase T, Nakamura T, Takahashi K, Yoshida H, Nakatani S, Tsuda A, Morioka T, Mori K, Imanishi Y, Hirata K, Emoto M.   +13 more
europepmc   +2 more sources

Xanthine Oxidoreductase Inhibitor Use Associated With Reduced Risk of Sarcopenia and Severe Sarcopenia in Patients Undergoing Hemodialysis. [PDF]

Front Med (Lausanne), 2022
Background Xanthine oxidoreductase (XOR) inhibition reduces reactive oxygen species (ROS) production and enhances adenosine triphosphate (ATP) synthesis. We investigated the protective effects of XOR inhibitor treatment on sarcopenia, frequently observed
Kurajoh M, Mori K, Miyabe M, Matsufuji S, Kizu A, Tsujimoto Y, Emoto M.   +6 more
europepmc   +2 more sources

Uric acid shown to contribute to increased oxidative stress level independent of xanthine oxidoreductase activity in MedCity21 health examination registry

Scientific Reports, 2021
Uric acid has both antioxidant and pro-oxidant properties in vitro by scavenging and production of reactive oxygen species (ROS). This cross-sectional study examined whether uric acid possesses effects on oxidative stress under physiological conditions ...
Masafumi Kurajoh, S. Fukumoto, Shio Yoshida, Seigo Akari, T. Murase, Takashi Nakamura, Haruka Ishii, H. Yoshida, Yuki Nagata, T. Morioka, K. Mori, Y. Imanishi, K. Hirata, M. Emoto   +13 more
semanticscholar   +1 more source

Computational Insights into the Inhibition Mechanism of Xanthine Oxidoreductase by Oxipurinol

, 2023
Xanthine oxidoreductase (XOR) is a molybdopterin-containing enzyme found in many living organisms. Its function is to convert hypoxanthine to xanthine and subsequently to urate, which are the final steps in purine elimination in humans.
G. Andrés, Cisneros, Yazdan, Maghsoud, Chao, Dong   +2 more
core   +1 more source

Shortage of Cellular ATP as a Cause of Diseases and Strategies to Enhance ATP

Frontiers in Pharmacology, 2019
Germline mutations in cellular-energy associated genes have been shown to lead to various monogenic disorders. Notably, mitochondrial disorders often impact skeletal muscle, brain, liver, heart, and kidneys, which are the body’s top energy-consuming ...
Todd A. Johnson, H. A. Jinnah, Naoyuki Kamatani   +2 more
doaj   +1 more source

Role of urate, xanthine oxidase and the effects of allopurinol in vascular oxidative stress [PDF]

, 2009
Oxidative stress plays an important role in the progression of vascular endothelial dysfunction. The two major systems generating vascular oxidative stress are the NADPH oxidase and the xanthine oxidase pathways. Allopurinol, a xanthine oxidase inhibitor,
Struthers, Allan D., Jacob George, George, Jacob   +2 more
core   +1 more source

Role of Xanthine Oxidoreductase as an Antimicrobial Agent [PDF]

Infection and Immunity, 2004
Xanthine oxidoreductase (XOR) is widely distributed in mammalian tissues and has long been known to be a major constituent of the milk fat globule membrane (MFGM), which surrounds fat globules in cow's milk ([36][1], [50][2]).
Hannah M, Martin, John T, Hancock, Vyv, Salisbury, Roger, Harrison   +3 more
openaire   +2 more sources