Results 21 to 30 of about 77,092 (210)

Xanthine oxidoreductase and xanthine oxidase in human cornea. [PDF]

Histology and histopathology, 2002
Xanthine oxidoreductase (xanthine dehydrogenase + xanthine oxidase) is a complex enzyme that catalyzes the oxidation of hypoxanthine to xanthine, subsequently producing uric acid. The enzyme complex exists in separate but interconvertible forms, xanthine dehydrogenase and xanthine oxidase, which generate reactive oxygen species (ROS), a well known ...
Cejkova, J., Ardan, T., Filipec, M., Midelfart, A.   +3 more
openaire   +4 more sources

Metabolic syndrome and cancer risk: The role of xanthine oxidoreductase [PDF]

Redox Biology, 2019
Obesity and related pathologies such as diabetes and metabolic syndrome are associated with chronic inflammation and cancer. The serum level of xanthine oxidoreductase (XOR) is correlated to obesity-associated metabolic disorders.
Maria Giulia Battelli, Massimo Bortolotti, Letizia Polito, Andrea Bolognesi   +3 more
doaj   +2 more sources

The nitrite reductase activity of xanthine oxidoreductase sustains cardiovascular health as mice age [PDF]

Redox Biology
Background: Xanthine oxidoreductase (XOR) is a multi-functional enzyme that metabolises purines generating uric acid and generates reactive oxygen species. Both functions have been implicated in the pathogenesis of cardiovascular disease.
Nicki Dyson, Rayomand S. Khambata, Tipparat Parakaw, Gianmichele Massimo, Ngan HH. Khuat, Annika A. Noor, Lorna C. Gee, Ivy Lim, Umme Siddique, Andrew J. Sullivan, Jonathan W. Ho, Krishnaraj Rathod, Michael R. Barnes, Claudia P. Cabrera, Amrita Ahluwalia   +14 more
doaj   +2 more sources

Xanthine oxidoreductase in cancer: more than a differentiation marker [PDF]

Cancer Medicine, 2015
AbstractHuman xanthine oxidoreductase (XOR) catalyzes the last two steps of purine catabolism and is present in two interconvertible forms, which may utilize O2 or NAD+ as electron acceptors. In addition to uric acid, XOR products may comprise reactive oxygen and nitrogen species that have many biologic effects, including inflammation, endothelial ...
BATTELLI, MARIA GIULIA, POLITO, LETIZIA, BORTOLOTTI, MASSIMO, BOLOGNESI, ANDREA   +3 more
openaire   +5 more sources

Tissue xanthine oxidoreductase activity in a mouse model of aristolochic acid nephropathy [PDF]

FEBS Open Bio, 2021
Xanthine oxidoreductase (XOR) is a critical enzyme in purine metabolism and uric acid production, and its levels are reported to increase during stress, thereby promoting organ damage.
Takeo Ishii, Tomohiro Kumagae, Hiromichi Wakui, Shingo Urate, Shohei Tanaka, Eriko Abe, Toru Suzuki, Takahiro Yamaji, Sho Kinguchi, Ryu Kobayashi, Kotaro Haruhara, Takashi Nakamura, Shuzo Kobayashi, Kouichi Tamura   +13 more
doaj   +2 more sources

A new route to peroxynitrite: a role for xanthine oxidoreductase [PDF]

FEBS Letters, 2000
Peroxynitrite, a potent oxidising, nitrating and hydroxylating agent, results from the reaction of nitric oxide with superoxide. We show that peroxynitrite can be produced by the action of a single enzyme, xanthine oxidoreductase (XOR), in the presence of inorganic nitrite, molecular oxygen and a reducing agent, such as pterin.
Godber, Ben L.J, Doel, Justin J, Durgan, Joanne, Eisenthal, Robert, Harrison, Roger   +4 more
openaire   +3 more sources

Plasma xanthine oxidoreductase activity in Japanese patients with type 2 diabetes across hospitalized treatment [PDF]

Journal of Diabetes Investigation, 2021
Aims/Introduction Xanthine oxidoreductase (XOR) is an enzyme that catalyzes hypoxanthine and xanthine to xanthine and uric acid, respectively. Plasma XOR activity has recently been measured in humans.
Yusuke Kawachi, Yuya Fujishima, Hitoshi Nishizawa, Hirofumi Nagao, Takashi Nakamura, Seigo Akari, Takayo Murase, Naohiro Taya, Kazuo Omori, Akimitsu Miyake, Shiro Fukuda, Mitsuyoshi Takahara, Shunbun Kita, Naoto Katakami, Norikazu Maeda, Iichiro Shimomura   +15 more
doaj   +4 more sources

Xanthine Oxidoreductase Is a Regulator of Adipogenesis and PPARγ Activity [PDF]

Cell Metabolism, 2007
In an effort to identify novel candidate regulators of adipogenesis, gene profiling of differentiating 3T3-L1 preadipocytes was analyzed using a novel algorithm. We report here the characterization of xanthine oxidoreductase (XOR) as a novel regulator of adipogenesis. XOR lies downstream of C/EBPbeta and upstream of PPARgamma, in the cascade of factors
Cheung, Kevin J., Tzameli, Iphigenia, Pissios, Pavlos, Rovira, Ilsa, Gavrilova, Oksana, Ohtsubo, Toshio, Chen, Zhu, Finkel, Toren, Flier, Jeffrey S., Friedman, Jeffrey M.   +9 more
openaire   +3 more sources

Computational Characterization of the Inhibition Mechanism of Xanthine Oxidoreductase by Topiroxostat. [PDF]

ACS Catal, 2023
Xanthine oxidase (XO) is a member of the molybdopterin-containing enzyme family. It interconverts xanthine to uric acid as the last step of purine catabolism in the human body.
Maghsoud Y, Dong C, Cisneros GA.
europepmc   +2 more sources

Plasma Xanthine Oxidoreductase Activity Associated with Glycemic Control in Patients with Pre-Dialysis Chronic Kidney Disease

Kidney & Blood Pressure Research, 2021
Introduction: Xanthine oxidoreductase (XOR) activity plays an important role as a pivotal source of reactive oxygen species, which is associated with cardiovascular disease (CVD) events. Patients with CKD have increased risk of CVD events. In the present
Shinya Nakatani, Eiji Ishimura, Takayo Murase, Takashi Nakamura, Ayumi Nakatani, Norikazu Toi, Kozo Nishide, Hideki Uedono, Akihiro Tsuda, Masafumi Kurajoh, Shinsuke Yamada, Katsuhito Mori, Masaaki Inaba, Masanori Emoto   +13 more
doaj   +2 more sources