Results 21 to 30 of about 6,803 (119)

Shortage of Cellular ATP as a Cause of Diseases and Strategies to Enhance ATP

Frontiers in Pharmacology, 2019
Germline mutations in cellular-energy associated genes have been shown to lead to various monogenic disorders. Notably, mitochondrial disorders often impact skeletal muscle, brain, liver, heart, and kidneys, which are the body’s top energy-consuming ...
Todd A. Johnson, H. A. Jinnah, Naoyuki Kamatani   +2 more
doaj   +1 more source

Metabolic syndrome and cancer risk: The role of xanthine oxidoreductase

Redox Biology, 2019
Obesity and related pathologies such as diabetes and metabolic syndrome are associated with chronic inflammation and cancer. The serum level of xanthine oxidoreductase (XOR) is correlated to obesity-associated metabolic disorders.
Maria Giulia Battelli, Massimo Bortolotti, Letizia Polito, Andrea Bolognesi   +3 more
doaj   +1 more source

The Effects of Xanthine Oxidoreductase Inhibitors on Oxidative Stress Markers following Global Brain Ischemia Reperfusion Injury in C57BL/6 Mice. [PDF]

PLoS ONE, 2015
We demonstrated that 3-nitrotyrosine and 4-hydroxy-2-nonenal levels in mouse brain were elevated from 1 h until 8 h after global brain ischemia for 14 min induced with the 3-vessel occlusion model; this result indicates that ischemia reperfusion injury ...
Masahiro Yamaguchi, Ken Okamoto, Teruo Kusano, Yoko Matsuda, Go Suzuki, Akira Fuse, Hiroyuki Yokota   +6 more
doaj   +1 more source

Mechanism of porcine liver xanthine oxidoreductase mediated N-oxide reduction of cyadox as revealed by docking and mutagenesis studies. [PDF]

PLoS ONE, 2013
Xanthine oxidoreductase (XOR) is a cytoplasmic molybdenum-containing oxidoreductase, catalyzing both endogenous purines and exogenous compounds. It is suggested that XOR in porcine hepatocytes catalyzes the N-oxide reduction of quinoxaline 1,4-di-N ...
Chigang Chen, Guyue Cheng, Haihong Hao, Menghong Dai, Xu Wang, Lingli Huang, Zhenli Liu, Zonghui Yuan   +7 more
doaj   +1 more source

Oxidative stress in the pathogenesis of type 1 diabetes: the role of adipocyte xanthine oxidase

Бюллетень сибирской медицины, 2018
Rationale. According to modern understanding, oxidative stress plays an essential role in the underlying mechanisms for the emergence of type 1 and type 2 diabetes and development of complications in these conditions.
V. V. Ivanov, E. V. Shakhristova, E. A. Stepovaya, N. V. Litvjakov, N. A. Perekucha, O. L. Nosareva, T. S. Fedorova, V. V. Novitsky   +7 more
doaj   +1 more source

Putting xanthine oxidoreductase and aldehyde oxidase on the NO metabolism map: Nitrite reduction by molybdoenzymes

Redox Biology, 2018
Nitric oxide radical (NO) is a signaling molecule involved in several physiological and pathological processes and a new nitrate-nitrite-NO pathway has emerged as a physiological alternative to the ''classic'' pathway of NO formation from L-arginine ...
Luisa B. Maia, José J.G. Moura
doaj   +1 more source

Association of the plasma xanthine oxidoreductase activity with the metabolic parameters and vascular complications in patients with type 2 diabetes

Scientific Reports, 2021
Xanthine oxidoreductase (XOR) catalyzes the oxidation of hypoxanthine to xanthine, and of xanthine to uric acid. XOR also enhances the production of reactive oxygen species and causes endothelial dysfunction.
Tomoko Okuyama, Jun Shirakawa, Takashi Nakamura, Takayo Murase, Daisuke Miyashita, Ryota Inoue, Mayu Kyohara, Yu Togashi, Yasuo Terauchi   +8 more
doaj   +1 more source

The fundamental contribution of prof. Stirpe (and his research group) to the broadening of the scientific perspective on xanthine oxidoreductase

Advances in Redox Research, 2023
Human xanthine oxidoreductase (XOR) is a multilevel regulated enzyme, which has many physiological functions, but which is also involved in several pathological processes.
Maria Giulia Battelli, Massimo Bortolotti, Letizia Polito, Andrea Bolognesi   +3 more
doaj   +1 more source

Differential regulation of hypoxanthine and xanthine by obesity in a general population

Journal of Diabetes Investigation, 2020
Aims/Introduction Uric acid is synthesized by oxidation of hypoxanthine and xanthine using a catalyzing enzyme, xanthine oxidoreductase (XOR), which can be a source of reactive oxygen species.
Masato Furuhashi, Masayuki Koyama, Yukimura Higashiura, Takayo Murase, Takashi Nakamura, Megumi Matsumoto, Akiko Sakai, Hirofumi Ohnishi, Marenao Tanaka, Shigeyuki Saitoh, Norihito Moniwa, Kazuaki Shimamoto, Tetsuji Miura   +12 more
doaj   +1 more source

Comparative effects of topiroxostat and febuxostat on arterial properties in hypertensive patients with hyperuricemia

The Journal of Clinical Hypertension, 2021
Elevated serum uric acid is a cardiovascular risk factor in patients with hypertension, even when blood pressure (BP) is well controlled. Xanthine oxidoreductase inhibitors (XORi) reduce serum uric acid levels and have several other potential effects ...
Kazuomi Kario, Masafumi Nishizawa, Mari Kiuchi, Arihiro Kiyosue, Fumishi Tomita, Hiroshi Ohtani, Yasuhisa Abe, Hideyo Kuga, Satoshi Miyazaki, Takatoshi Kasai, Makiko Hongou, Takanori Yasu, Jin Kuramochi, Yoshihiro Fukumoto, Satoshi Hoshide, Ichiro Hisatome   +15 more
doaj   +1 more source