The fundamental contribution of prof. Stirpe (and his research group) to the broadening of the scientific perspective on xanthine oxidoreductase [PDF]
Advances in Redox Research, 2023 Human xanthine oxidoreductase (XOR) is a multilevel regulated enzyme, which has many physiological functions, but which is also involved in several pathological processes.
Maria Giulia Battelli +3 more
doaj +2 more sources
Xanthine Oxidoreductase Activities
, 2020 Xanthine oxidoreductase (XOR) is the enzyme that catalyzes the oxidation of hypoxanthine to xanthine and xanthine to uric acid. XOR is widely distributed throughout living organisms and is highly conserved in prokaryotic, plant, and animal species. XOR activity is very versatile, generating both pro-oxidant (primarily within the cell) and anti-oxidant (
Letizia Polito +3 more
openaire +2 more sources
Xanthine oxidoreductase inhibition ameliorates high glucose-induced glomerular endothelial injury by activating AMPK through the purine salvage pathway [PDF]
Scientific ReportsXanthine oxidoreductase (XOR) contributes to reactive oxygen species production. We investigated the cytoprotective mechanisms of XOR inhibition against high glucose (HG)-induced glomerular endothelial injury, which involves activation of the AMP ...
Keum-Jin Yang +5 more
doaj +2 more sources
Investigation of the Inhibition Mechanism of Xanthine Oxidoreductase by Oxipurinol: A Computational Study. [PDF]
J Chem Inf Model, 2023 Xanthine oxidoreductase (XOR) is an enzyme found in various organisms. It converts hypoxanthine to xanthine and urate, which are crucial steps in purine elimination in humans.
Maghsoud Y, Dong C, Cisneros GA.
europepmc +6 more sources
Hyperuricaemia, Xanthine Oxidoreductase and Ribosome‐Inactivating Proteins from Plants: The Contributions of Fiorenzo Stirpe to Frontline Research [PDF]
Molecules, 2017 The enzymes called ribosome‐inactivating proteins (RIPs) that are able to depurinate nucleic acids and arrest vital cellular functions, including protein synthesis, are still a frontline research field, mostly because of their promising medical ...
Andrea Bolognesi +3 more
doaj +2 more sources
Allopurinol and oxypurinol differ in their strength and mechanisms of inhibition of xanthine oxidoreductase. [PDF]
J Biol Chem, 2023 Xanthine oxidoreductase is a metalloenzyme that catalyzes the final steps in purine metabolism by converting hypoxanthine to xanthine and then uric acid.
Sekine M +6 more
europepmc +2 more sources
Mechanisms of Action of Malondialdehyde and 4-Hydroxynonenal on Xanthine Oxidoreductase
Archives of Biochemistry and Biophysics, 2001 Studies have been made on the possible involvement of malondialdehyde (MDA) and (E)-4-hydroxynon-2-enal (HNE), two terminal compounds of lipid peroxidation, in modifying xanthine oxidoreductase activity through interaction with the oxidase (XO) and/or dehydrogenase (XDH) forms.
G. Cighetti +3 more
openaire +4 more sources
Diurnal Variations in Serum Uric Acid, Xanthine, and Xanthine Oxidoreductase Activity in Male Patients with Coronary Artery Disease. [PDF]
Nutrients, 2023 Hyperuricemia is influenced by diet and can cause gout. Whether it is a potential risk factor for cardiovascular disease (CVD) remains controversial, and the mechanism is unclear.
Shimizu M +14 more
europepmc +2 more sources
Neurobiology of Disease, 2021 Inflammation and oxidative stress contribute to the pathophysiology of diabetic neuropathy. According to recent evidence, the modulation of macrophage polarization in peripheral nerves represents a potential therapeutic target for diabetic neuropathy ...
Kazuhisa Takahashi +9 more
doaj +1 more source
Computational Insights into the Inhibition Mechanism of Xanthine Oxidoreductase by Oxipurinol [PDF]
, 2023 Xanthine oxidoreductase (XOR) is a molybdopterin-containing enzyme found in many living organisms. Its function is to convert hypoxanthine to xanthine and subsequently to urate, which are the final steps in purine elimination in humans.
G. Andrés, Cisneros +2 more
core +2 more sources