Results 81 to 90 of about 38,964 (184)
Sesquiterpene lactones emerge as structurally diverse anticancer scaffolds with multifaceted mechanisms of action. Their biosynthesis, chemical diversity, structure–activity relationships, semisynthetic diversification, and molecular targets are integrated to highlight therapeutic opportunities and challenges.
Kedar Nimba Chaudhari +3 more
wiley +1 more source
Research Article Xanthine Oxidoreductase Reference Values in Platelet-Poor Plasma and Platelets in Healthy Volunteers [PDF]
Copyright © 2015 Elżbieta Cecerska-Heryc ́ et al.This is an open access article distributed under theCreative CommonsAttribution License, which permits unrestricted use, distribution, and reproduction in anymedium, provided the originalwork is properly ...
Urbanska Marta +7 more
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Drosophila Melanogaster as a Model for Molybdo-Flavoenzyme Mediated Protection against Chemical and Physical Stress [PDF]
Aldehyde oxidase (AO) and xanthine oxidoreductase (XOR) are molybdo-flavoenzymes (MFEs) involved in the oxidation of hundreds of endogenous and exogenous aldehydes and N-heterocyclic compounds many of which are drugs, vitamins and environmental ...
Al Salhen, Khaled S
core +1 more source
Carica papaya preparations have produced changes in antioxidant, Nrf2‐related, cholinergic, amyloid‐associated, inflammatory, apoptotic, neuronal, and behavioral endpoints in preclinical models. The evidence is model‐ and preparation‐specific, and clinical efficacy has not been established. ABSTRACT Carica papaya (C.
Rakib Hossan +9 more
wiley +1 more source
A Post–NGP Mitsuokella jalaludinii as a Therapeutic Candidate for Gout
Schematic summary of the therapeutic mechanisms and evaluation of the post–NGP strain M. jalaludinii PMC73 for gout. PMC73 demonstrated uric acid–lowering efficacy through purine catabolism and hypoxanthine utilization, along with intracellular uric acid reduction in macrophages.
Mohammed Solayman Hossain +13 more
wiley +1 more source
Introduction: Elevated levels of serum uric acid (SUA) are strongly associated with several components of the metabolic syndrome, particularly obesity.
Meijuan Dong +5 more
doaj +1 more source
Enzyme@Silicone: A Versatile Combo for Robust Synthetic Biocatalysis?
Silicone‐based polymers are versatile materials for enzyme immobilization, offering unique advantages such as chemical inertness, thermal stability, and tunable morphology. This review highlights their applications in synthetic biocatalysis, from batch to continuous processes, and addresses key challenges such as mass transport limitations and ...
Marion B. Ansorge‐Schumacher
wiley +1 more source
An STI‐guided metagenomic association framework links soybean salt‐tolerance phenotypes with rhizosphere microbiome composition and network organization in natural saline soils. The approach identifies candidate beneficial taxa, including Thalassospira xiamenensis, and provides an efficient strategy for mining stress‐protective microbes from native ...
Yu Luo +3 more
wiley +1 more source
Proton pump inhibitors (PPIs) are widely used drugs that may increase the cardiovascular risk by mechanisms not entirely known. While PPIs increase asymmetric dimethylarginine (ADMA) levels and inhibit nitric oxide production, it is unknown whether ...
Lucas C. Pinheiro +5 more
doaj +1 more source
Differences in Activities of Antioxidant Superoxide Dismutase, Glutathione Peroxidase and Prooxidant Xanthine Oxidoreductase/Xanthine Oxidase in the Normal Corneal Epithelium of Various Mammals [PDF]
Summary Under normal conditions, antioxidants at the corneal surface are balanced with the production of reactive oxygen species without any toxic effects.
J Pláteník +7 more
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