Results 91 to 100 of about 38,964 (184)

Relationship between xanthine oxidoreductase and renal damage in chronic kidney disease patients

Linchuang shenzangbing zazhi, 2020
Objective To explore the relationship between xanthine oxidoreductase(XOR)activity and kidney injury in patients with chronic kidney disease(CKD).Methods A total of 105 patients with CKD were selected as the research objects in this study.We measured ...
ZHANG Yi-yuan, ZHAO Ming-yue, WEI Juan-yu, ZHANG Shuai, XU Meng, ZHENG Dong-hui   +5 more
doaj  

Tissue- and cell-specific expression of mouse xanthine oxidoreductase gene in vivo: regulation by bacterial lipopolysaccharide

, 1995
The expression of the xanthine oxidoreductase gene was studied in various mouse organs and tissues, under basal conditions and on treatment with bacterial lipopolysaccharide.
M. Li Calzi, M. Terao, M. Kurosaki, E. Garattini, E. Scanziani   +4 more
core   +1 more source

Relationship between plasma xanthine oxidoreductase activity and left ventricular ejection fraction and hypertrophy among cardiac patients.

PLoS ONE, 2017
Background and purposeXanthine oxidoreductase (XOR), which catalyzes purine catabolism, has two interconvertible forms, xanthine dehydrogenase and xanthine oxidase, the latter of which produces superoxide during uric acid (UA) synthesis.
Yuki Fujimura, Yohei Yamauchi, Takayo Murase, Takashi Nakamura, Shu-Ichi Fujita, Tomohiro Fujisaka, Takahide Ito, Koichi Sohmiya, Masaaki Hoshiga, Nobukazu Ishizaka   +9 more
doaj   +1 more source

Xanthine oxidoreductase in atherosclerosis pathogenesis: Not only oxidative stress

Atherosclerosis, 2014
Endothelial xanthine oxidoreductase (XOR) together with NAD(P)H oxidase and nitric oxide (NO) synthase plays a physiologic role in inflammatory signalling, the regulation of NO production and vascular function. The oxidative stress generated by these enzymes may induce endothelial dysfunction, leading to atherosclerosis, cardiovascular diseases and ...
BATTELLI, MARIA GIULIA, POLITO, LETIZIA, BOLOGNESI, ANDREA   +2 more
openaire   +4 more sources

Mechanistic Studies on Xanthine Oxidoreductase Enzymes [PDF]

, 2011
In humans, the xanthine oxidoreductase enzymes are known to catalyze the final two steps of purine metabolism by converting hypoxanthine successively to xanthine and uric acid. Xanthine oxidoreductase also metabolizes a wide variety of drugs in vivo, and
Berhane, Abebe
core  

Dose-dependent effects of Allopurinol on human foreskin fibroblast cell and human umbilical vein endothelial cell under hypoxia [PDF]

, 2015
Allopurinol, an inhibitor of xanthine oxidase, has been used in clinical trials of patients with cardiovascular and chronic kidney disease. These are two pathologies with extensive links to hypoxia and activation of the transcription factor hypoxia ...
Sun, Yu, George Jacob, Sun Yu, Yu Sun, Sonia Rocha, Jacob George, George, Jacob, Rocha, Sonia, Rocha Sonia   +8 more
core   +1 more source

Crystallographic, Kinetic and Computational Studies on the Reaction Mechanism of Xanthine Oxidoreductase [PDF]

, 2011
Xanthine oxidoreductase is a molybdenum-containing enzyme which catalyzes the hydroxylation on sp2 hybridized carbon centers of a broad family of substrates including purines, aldehydes and various other heterocycles.
Cao, Hongnan
core  

Targeted knock-in mice expressing the oxidase-fixed form of xanthine oxidoreductase favor tumor growth.

, 2019
Xanthine oxidoreductase has been implicated in cancer. Nonetheless, the role played by its two convertible forms, xanthine dehydrogenase (XDH) and oxidase (XO) during tumorigenesis is not understood. Here we produce XDH-stable and XO-locked knock-in (ki)
Ehirchiou, D., Castelblanco, M., Acha-Orbea, H., Chobaz, V., Nishino, T., Kusano, T., Okamoto, K., Busso, N., Nasi, S., Lavanchy, C., Matsumura, T., So, A., Okamoto K, Busso N, Matsumura T, Ehirchiou D, Kusano T, Chobaz V, Lavanchy C, Castelblanco M, Nasi S, So A, Nishino T, Acha-Orbea H   +23 more
core   +1 more source

Xanthine oxidoreductase and cardiovascular disease: molecular mechanisms and pathophysiological implications

, 2004
There is substantial evidence that oxidative stress participates in the pathophysiology of cardiovascular disease. Biochemical, molecular and pharmacological studies further implicate xanthine oxidoreductase (XOR) as a source of reactive oxygen species ...
Berry, Cristine E, Hare, Joshua M
core   +1 more source

Disrupted NAD(P) Metabolism and Xanthine Dehydrogenase in a Stress-Induced Rat Model of Depression: NMR Metabolomics Insights

Metabolites
Background: Clinical findings have shown a negative correlation between the severity of depressive symptoms and serum uric acid levels in men, yet the role of metabolic regulation in the pathophysiology of depression remains largely unknown.
Songjiao Chen, Jumeng Wei, Yongchi Wang, Yidan Yao, Haibo Wang, Jie Peng, Jinquan Li   +6 more
doaj   +1 more source