Results 111 to 120 of about 77,092 (210)

Liensinine Ameliorating Oxidative Damage to Vascular Endothelium In Vitro via Upregulating eNOS and Nrf2/HO‐1 Signaling

Food Science &Nutrition, Volume 14, Issue 6, June 2026.
The present studies of network pharmacology, molecular docking and molecular dynamics simulation indicated that liensinine might ameliorate oxidative damage to vascular endothelium (ODVE) by regulating the targets of Nrf2, which is encoded by the NFE2L2 gene. Then the in vitro study further showed that liensinine exhibited an obvious protection against
Feng Gao, Fengjiao Deng, Qiaowei Du, Tianya Xia, Yayi Deng, Shuang Liu, Bin Yu, Chenxiao Shan   +7 more
wiley   +1 more source

Localization of xanthine oxidoreductase activity using the tissue protectant polyvinyl alcohol and final electron acceptor Tetranitro BT.

, 1991
We have detected xanthine oxidoreductase activity in unfixed cryostat sections of rat and chicken liver, rat duodenum, and bovine mammary gland using the tissue protectant polyvinyl alcohol, the electron carrier 1-methoxyphenazine methosulfate, the ...
R Gossrau, W M Frederiks, A Kooij, C J Van Noorden   +3 more
core   +1 more source

Oxidative Stress in the Tumor Immune Microenvironment: Mechanisms and Therapeutic Perspectives

MedComm – Oncology, Volume 5, Issue 2, June 2026.
Oxidative stress is involved in several key processes in cancer, including redox regulation, DNA damage, post‐translational modifications, transcriptional regulation, epigenetic modifications, metabolic reprogramming, cell death, and immune modulation. These mechanisms collectively influence tumor progression, immune evasion, and therapeutic responses,
Zhen Wang, Bowen Li, Pan Tang, Fanchen Yan, Shuxin Wang, Guiying Leng, Panduo Dawa, Yuansi Chen, Yihan Guo, Pan Yang, Yi Li, Siyu Liu, Erdan Dong, Siyuan Qin, Zhoufeng Wang   +14 more
wiley   +1 more source

Research Article Xanthine Oxidoreductase Reference Values in Platelet-Poor Plasma and Platelets in Healthy Volunteers [PDF]

, 2016
Copyright © 2015 Elżbieta Cecerska-Heryc ́ et al.This is an open access article distributed under theCreative CommonsAttribution License, which permits unrestricted use, distribution, and reproduction in anymedium, provided the originalwork is properly ...
Urbanska Marta, Elhbieta Cecerska-heryt, Anna Jesionowska, Pawlak Dominika, Szupiluk Klaudyna, Mdczka Dominika, Barbara Dobwgowska, Siewierska Katarzyna   +7 more
core  

Relationship between plasma xanthine oxidoreductase activity and left ventricular ejection fraction and hypertrophy among cardiac patients.

PLoS ONE, 2017
Background and purposeXanthine oxidoreductase (XOR), which catalyzes purine catabolism, has two interconvertible forms, xanthine dehydrogenase and xanthine oxidase, the latter of which produces superoxide during uric acid (UA) synthesis.
Yuki Fujimura, Yohei Yamauchi, Takayo Murase, Takashi Nakamura, Shu-Ichi Fujita, Tomohiro Fujisaka, Takahide Ito, Koichi Sohmiya, Masaaki Hoshiga, Nobukazu Ishizaka   +9 more
doaj   +1 more source

Uric Acid in Metabolic Dysfunction‐Associated Steatotic Liver Disease

Portal Hypertension &Cirrhosis, Volume 5, Issue 2, Page 189-206, June 2026.
MASLD is the most prevalent chronic liver disease worldwide, yet effective pharmacological treatments remain limited. Hyperuricemia is now recognized as a key driver of hepatic steatosis, inflammation, and fibrosis, with elevated serum uric acid levels independently predicting hepatocellular carcinoma and liver‐related mortality.
Rong Wang, Zhenyu Liu, Jun Lin, Weijing Zhang, Xianzhi Liu, Tong Zhang   +5 more
wiley   +1 more source

Harnessing Trace Elements: Novel Radiosensitization Strategies for Enhanced Cancer Radiotherapy

Rare Metals, Volume 45, Issue 6, June 2026.
ABSTRACT Radiotherapy (RT) is one of the core methods of comprehensive cancer treatment. Globally, more than 40% of cancer patients rely on radiotherapy to achieve tumor control, cure or palliative relief. However, radiation resistance, immunosuppression and normal tissue injury limit its clinical application.
Yuhuan Zhang, Yizhi Ge, Hongguang Xiang, Ji Liu, Yu Tian, Yan Shen, Dan Zong   +6 more
wiley   +1 more source

Benzofuran‐Based Uricosuric Agents: History, Roles, and Challenges

ChemistrySelect, Volume 11, Issue 24, 25 June 2026.
Benzofuran‐based uricosuric agents represent a privileged medicinal chemistry scaffold for gout therapy. Structural optimization of benzbromarone‐related derivatives has improved hURAT1 inhibitory potency, metabolic stability, and urate‐lowering efficacy, while reducing hepatotoxic liability.
Raed M. Al‐Zoubi, Basma Hanbali, Mai Elaarag, Zainab Fares, Enas A. Al‐Hurani, Sally R. Al‐Zoubi, Mohanad Shkoor, Abdelali Agouni   +7 more
wiley   +1 more source

Early adversity and the comorbidity between metabolic disease and psychopathology

The Journal of Physiology, Volume 604, Issue 11, Page 4338-4377, 1 June 2026.
Abstract figure legend Hierarchical diagram representing the interplay between the genetic background and early life adversities and its effect on multiple physiological processes that ultimately impact on the risk for the comorbdity between psychopathology and cardiometabolic disorders.
Ameyalli Gómez‐Ilescas, Patricia Pelufo Silveira   +1 more
wiley   +1 more source

Phenolics Contents, Xanthine Oxidoreductase Inhibitory Potential, Antibacterial and Antioxidant Activities of Cachrys libanotis L. Root Extracts

, 2020
To date, no studies have investigated the phytochemical screening and biological activities of Cachrys libanotis L. traditionally used for the treatment of gout and rheumatism.
Trabsa, Hayat, Boussoualim, Naouel, Baghiani, Abderrahmane, Boumerfeg, Sabah, AOUACHRIA, Sana, Benslama, Abderrahim   +5 more
core   +1 more source