Results 1 to 10 of about 118,750 (323)

Apoptosome activation, an important molecular instigator in 6-mercaptopurine induced Leydig cell death. [PDF]

, 2015
Leydig cells are crucial to the production of testosterone in males. It is unknown if the cancer chemotherapeutic drug, 6-mercaptopurine (6 MP), produces Leydig cell failure among adult survivors of childhood acute lymphoblastic leukemia. Moreover, it is
Bao, Ju, Chemaitilly, Wassim, Frase, Sharon, Green, Daniel M, Janke, Laura, Lynch, John, Morgan, Jessica A, Opferman, Joseph T, Panetta, John C, Schuetz, John D, Wang, Yao, Zheng, Jie   +11 more
core   +1 more source

Effect of ischemia on the canine large bowel: A comparison with the small intestine [PDF]

, 1996
Mucosal injury caused by ischemia and reperfusion has been well documented with the small intestine, but little is known about the colon. In the present study, the effect of warm and cold ischemia on the canine colon was studied and compared to that on ...
Ikoma, A, Nakamura, K, Starzl, TE, Takeyoshi, I, Todo, S, Zhang, S, Zhu, Y   +6 more
core   +1 more source

Propentofylline Improves Thiol-Based Antioxidant Defenses and Limits Lipid Peroxidation following Gliotoxic Injury in the Rat Brainstem

Biomedicines, 2023
Propentofylline (PROP) is a methylated xanthine compound that diminishes the activation of microglial cells and astrocytes, which are neuronal cells strongly associated with many neurodegenerative diseases.
Deborah E. M. Baliellas, Marcelo P. Barros, Cristina V. Vardaris, Maísa Guariroba, Sandra C. Poppe, Maria F. Martins, Álvaro A. F. Pereira, Eduardo F. Bondan   +7 more
doaj   +1 more source

Diabetic Cardiovascular Disease Induced by Oxidative Stress. [PDF]

, 2015
Cardiovascular disease (CVD) is the leading cause of morbidity and mortality among patients with diabetes mellitus (DM). DM can lead to multiple cardiovascular complications, including coronary artery disease (CAD), cardiac hypertrophy, and heart failure
Adam, Matti, Jagger, Ann, Kayama, Yosuke, Raaz, Uwe, Sakamoto, Masaya, Schellinger, Isabel N, Spin, Joshua M, Suzuki, Hirofumi, Toyama, Kensuke, Tsao, Philip S   +9 more
core   +2 more sources

Search of protein kinase CK2 inhibitors based on purine-2,6-diones derivatives [PDF]

The Ukrainian Biochemical Journal, 2017
This work is aimed to the search of protein kinase CK2 inhibitors among the purine-2,6-dione derivatives by molecular docking and biochemical tests. It was found that the most active compound 8-[2-[(3-methoxyphenyl)methylidene]hydrazine-1-yl]-3-methyl-7-(
M. V. Protopopov, O. V. Ostrynska, D. H. Ivanchenko, S. A. Starosyla, V. G. Bdzhola, M. I. Romanenko, S. M. Yarmoluk   +6 more
doaj   +1 more source

Synthesis of Novel Fluorinated Xanthine Derivatives with High Adenosine A_2B Receptor Binding Affinity

Pharmaceuticals, 2021
The G protein-coupled adenosine A2B receptor is suggested to be involved in various pathological processes accompanied by increased levels of adenosine as found in inflammation, hypoxia, and cancer.
Marcel Lindemann, Sladjana Dukic-Stefanovic, Sonja Hinz, Winnie Deuther-Conrad, Rodrigo Teodoro, Cathleen Juhl, Jörg Steinbach, Peter Brust, Christa E. Müller, Barbara Wenzel   +9 more
doaj   +1 more source

Structural and Conformational Studies on Carboxamides of 5,6-Diaminouracils—Precursors of Biologically Active Xanthine Derivatives

Molecules, 2019
8-Arylethynylxanthine derivatives are potent, selective adenosine A2A receptor antagonists, which represent (potential) therapeutics for Parkinson’s disease, Alzheimer’s dementia, and the immunotherapy of cancer.
Daniel Marx, Gregor Schnakenburg, Stefan Grimme, Christa E. Müller   +3 more
doaj   +1 more source

Nanomaterial-Doped Xerogels for Biosensing Measurements of Xanthine in Clinical and Industrial Applications

Gels, 2023
First-generation amperometric xanthine (XAN) biosensors, assembled via layer-by-layer methodology and featuring xerogels doped with gold nanoparticles (Au-NPs), were the focus of this study and involved both fundamental exploration of the materials as ...
Quang Minh Dang, Ann H. Wemple, Michael C. Leopold   +2 more
doaj   +1 more source

Assessing Meat Freshness via Nanotechnology Biosensors: Is the World Prepared for Lightning-Fast Pace Methods?

Biosensors, 2023
In the rapidly evolving field of food science, nanotechnology-based biosensors are one of the most intriguing techniques for tracking meat freshness.
Wen Xia Ling Felicia, Kobun Rovina, Nasir Md Nur ‘Aqilah, Joseph Merillyn Vonnie, Koh Wee Yin, Nurul Huda   +5 more
doaj   +1 more source

Can adenine nucleotides predict primary nonfunction of the human liver homograft? [PDF]

, 1994
Sixty-eight primary liver grafts were analyzed to see whether adenine nucleotides (AN: ATP, ADP, and AMP) or purine catabolites (PC: adenosine, inosine, hypoxanthine, and xanthine) of tissue or effluent can predict primary graft nonfunction.
Bronsther, O, Fujita, S, Hamamoto, I, Irish, W, Nakamura, K, Starzl, TE, Takaya, S, Todo, S, Van Gulik, TM   +8 more
core   +1 more source