Results 21 to 30 of about 75,914 (267)

Genetic predisposition to porto‐sinusoidal vascular disorder: A functional genomic‐based, multigenerational family study

Hepatology, EarlyView., 2022
A deleterious variant of FCHSD1 results in mTOR pathway overactivation and may cause porto‐sinusoidal vascular disorder (PSVD). The pedigree of the family demonstrated an autosomal dominant disease with variable expressivity. Whole‐genome sequencing and Sanger sequencing both validated the existence of the FCHSD1 variant and the heterozygosity of c ...
Jingxuan Shan, André Megarbane, Aziz Chouchane, Deepak Karthik, Ramzi Temanni, Atilio Reyes Romero, Huiying Hua, Chun Pan, Xixi Chen, Murugan Subramanian, Chadi Saad, Hamdi Mbarek, Cybel Mehawej, Eliane Chouery, Sirin W. Abuaqel, Alexander Dömling, Sami Remadi, Cesar Yaghi, Pu Li, Lotfi Chouchane   +19 more
wiley   +1 more source

<i>Staphylococcus aureus</i>-derived xanthine exacerbates allergic rhinitis-induced olfactory dysfunction through promoting Th17 cell differentiation and IL-17A production. [PDF]

Clin Transl Immunology
Staphylococcus aureus‐derived xanthine exacerbates allergic rhinitis‐associated olfactory dysfunction by promoting Th17 cell differentiation and IL‐17A production. IL‐17A neutralisation alleviates olfactory sensory neuron loss and improves olfactory function. Abstract Objectives Allergic rhinitis (AR) is frequently accompanied by olfactory dysfunction (
Hu Y, Wang W, Yang T, Song X, Wang Y, Cheng Y, Mou Y, Ren C, Song X.   +8 more
europepmc   +2 more sources

Caffeine affects the biological responses of human hematopoietic cells of myeloid lineage via downregulation of the mTOR pathway and xanthine oxidase activity [PDF]

, 2015
Correction of human myeloid cell function is crucial for the prevention of inflammatory and allergic reactions as well as leukaemia progression. Caffeine, a naturally occurring food component, is known to display anti-inflammatory effects which have ...
Sumbayev, Vadim V., Gibbs, Bernhard F, Yasinska, Inna M., Sumbayev, Vadim V, Casely-Hayford, Maxwell A., Gibbs, Bernhard F., Vadim V. Sumbayev, Berger, Steffen M., Maryam Abooali, Prokhorov, Alexandr, Yasinska, Inna M, Abooali, Maryam, Berger, Steffen Michael, Isabel Gonçalves Silva, Bernhard F. Gibbs, Elizaveta Fasler-Kan, Fasler-Kan, Elizaveta, Alexandr Prokhorov, Gonçalves Silva, Isabel, Casely-Hayford, Maxwell A, Maxwell A. Casely-Hayford, Inna M. Yasinska, Steffen M. Berger, Abooali M, Casely-Hayford MA, Berger SM, Yasinska IM, Gibbs BF, Sumbayev VV, Prokhorov A, Gonçalves Silva I, Fasler-Kan E   +31 more
core   +2 more sources

The Effect of Two Weeks of High-intensity Interval Training on Salvage nucleotide pathway [PDF]

فیزیولوژی ورزش و فعالیت بدنی, 2022
Purpose: The effects of exercise adaptation on improving the purine nucleotides components are inevitable, and physical activity improves the purine nucleotide salvage pathway.
Abbas Ghanbari Niaki, Rouhollah Haghshenas Gatabi   +1 more
doaj   +1 more source

Computational Insights into the Inhibition Mechanism of Xanthine Oxidoreductase by Oxipurinol [PDF]

, 2023
Xanthine oxidoreductase (XOR) is a molybdopterin-containing enzyme found in many living organisms. Its function is to convert hypoxanthine to xanthine and subsequently to urate, which are the final steps in purine elimination in humans.
G. Andrés, Cisneros, Yazdan, Maghsoud, Chao, Dong   +2 more
core   +2 more sources

Xanthine-Based Photoaffinity Probes Allow Assessment of Ligand Engagement by TRPC5 Channels

, 2020
TRPC1/4/5 cation channels are emerging drug targets for the treatment of, amongst others, central nervous system (CNS) disorders, kidney disease, and cardiovascular and metabolic disease.
Isabelle Pickles (8484838), Nikil Kapur (8484849), Stephen Muench (8484851), David Beech (8484850), Matthew Burnham (8484973), Claudia Bauer (8484846), Megan Wright (8484852), Robin Bon (6443525), Aisling Minard (8484843), Stuart Warriner (8484853)   +9 more
core   +1 more source

Fast, Efficient, and Versatile Synthesis of 6-amino-5-carboxamidouracils as Precursors for 8-Substituted Xanthines

Frontiers in Chemistry, 2019
Substituted xanthine derivatives are important bioactive molecules. Herein we report on a new, practical synthesis of 6-amino-5-carboxamidouracils, the main building blocks for the preparation of 8-substituted xanthines, by condensation of 5,6 ...
Daniel Marx, Lukas M. Wingen, Gregor Schnakenburg, Christa E. Müller, Matthias S. Scholz   +4 more
doaj   +1 more source

Simultaneous Determination of Xanthine and Hypoxanthine Using Polyglycine/rGO-Modified Glassy Carbon Electrode

Molecules, 2023
A novel electrochemical sensor was developed for selective and sensitive determination of xanthine (XT) and hypoxanthine (HX) based on polyglycine (p-Gly) and reduced graphene oxide (rGO) modified glassy carbon electrode (GCE). A mixed dispersion of 7 μL
Ting Wang, Lin Zhang, Chengyu Zhang, Dongmei Deng, Dejia Wang, Liqiang Luo   +5 more
doaj   +1 more source

Propentofylline Improves Thiol-Based Antioxidant Defenses and Limits Lipid Peroxidation following Gliotoxic Injury in the Rat Brainstem

Biomedicines, 2023
Propentofylline (PROP) is a methylated xanthine compound that diminishes the activation of microglial cells and astrocytes, which are neuronal cells strongly associated with many neurodegenerative diseases.
Deborah E. M. Baliellas, Marcelo P. Barros, Cristina V. Vardaris, Maísa Guariroba, Sandra C. Poppe, Maria F. Martins, Álvaro A. F. Pereira, Eduardo F. Bondan   +7 more
doaj   +1 more source

Structural and Conformational Studies on Carboxamides of 5,6-Diaminouracils—Precursors of Biologically Active Xanthine Derivatives

Molecules, 2019
8-Arylethynylxanthine derivatives are potent, selective adenosine A2A receptor antagonists, which represent (potential) therapeutics for Parkinson’s disease, Alzheimer’s dementia, and the immunotherapy of cancer.
Daniel Marx, Gregor Schnakenburg, Stefan Grimme, Christa E. Müller   +3 more
doaj   +1 more source