Results 11 to 20 of about 4,011 (296)
One pot synthesis, antimicrobial and antioxidant activities of fused uracils: pyrimidodiazepines, lumazines, triazolouracil and xanthines [PDF]
Chemistry Central Journal, 2017 Background Uracil derivatives have a great attraction because they play an important role in pharmacological activities. Pyrimidodiazepines, lumazines, triazolopyrimidines and xanthines have significant wide spectrum activities including anticancer ...
Samar A. El-Kalyoubi +2 more
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Efficacy and safety profile of xanthines in COPD: a network meta-analysis [PDF]
European Respiratory Review, 2018 Theophylline can still have a role in the management of stable chronic obstructive pulmonary disease (COPD), but its use remains controversial, mainly due to its narrow therapeutic window. Doxofylline, another xanthine, is an effective bronchodilator and
Mario Cazzola +6 more
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Determination of Flavonoids, Phenolic Acids, and Xanthines in Mate Tea (Ilex paraguariensis St.-Hil.) [PDF]
Journal of Analytical Methods in Chemistry, 2013 Raw material, different formulations of foods, and dietary supplements of mate demands control of the content of bioactive substances for which high performance thin layer chromatography (TLC), described here, presents simple and rapid approach for ...
Mirza Bojić +3 more
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eLife, 2021 Mutations in TP53 occur commonly in the majority of human tumors and confer aggressive tumor phenotypes, including metastasis and therapy resistance. CB002 and structural-analogs restore p53 signaling in tumors with mutant-p53 but we find that unlike ...
Liz Hernandez Borrero +8 more
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Search for potential hypoglycemic agents among potassium salts of 3-benzyl-8-substituted xanthines
Aktualʹnì Pitannâ Farmacevtičnoï ì Medičnoï Nauki ta Praktiki, 2022 Nowadays, the prevalence of metabolic syndrome (MS) is a serious problem among the world’s population. Metabolic syndrome includes the so-called “deadly” quartet – hypertension, type 2 diabetes mellitus (diabetes mellitus), dyslipidemia and alimentary ...
K. V. Aleksandrova +4 more
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Zaporožskij Medicinskij Žurnal, 2021 Statin side effects are not a rare occurrence, in particular dyspeptic disorders, insomnia, headache, skin erythema, rash are often noted. All of this determines scientists to find new effective and low-toxic hypolipidemic agents.
I. M. Bilai +2 more
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The Transcriptional Repressor Orphan Nuclear Receptor TLX Is Responsive to Xanthines [PDF]
, 2021 [Image: see text] The orphan nuclear receptor tailless homologue (TLX) is expressed almost exclusively in neural stem cells acting as an essential factor for their survival and is hence considered as a promising drug target in neurodegeneration. However,
Knapp, Stefan +21 more
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Cells, 2021 Splicing defects caused by mutations in the consensus sequences at the borders of introns and exons are common in human diseases. Such defects frequently result in a complete loss of function of the protein in question.
Antje Banning, Ritva Tikkanen
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Salification Controls the In-Vitro Release of Theophylline
Crystals, 2022 Sustained released formulation is the most used strategy to control the efficacy and the adverse reactions of an API (active pharmaceutical ingredient) with a narrow therapeutic index.
Laura Baraldi +5 more
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The cardiovascular effects of xanthines and selective PDE inhibitors: a risk–benefit analysis [PDF]
, 2020 Xanthines have been employed in the treatment of respiratory disorders since 1937, for the treatment of respiratory diseases such as COPD and asthma. However, xanthines, although effective, have a relatively narrow therapeutic window that has limited ...
Roberta Fusco +9 more
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