Results 51 to 60 of about 4,325,962 (256)

Adenosine Receptors and Asthma [PDF]

, 2009
The pathophysiological processes underlying respiratory diseases like asthma are complex, resulting in an overwhelming choice of potential targets for the novel treatment of this disease. Despite this complexity, asthmatic subjects are uniquely sensitive to a range of substances like adenosine, thought to act indirectly to evoke changes in respiratory ...
Constance N, Wilson, Ahmed, Nadeem, Domenico, Spina, Rachel, Brown, Clive P, Page, S Jamal, Mustafa   +5 more
openaire   +2 more sources

The dynamics of single spike-evoked adenosine release in the cerebellum [PDF]

, 2011
The purine adenosine is a potent neuromodulator in the brain, with roles in a number of diverse physiological and pathological processes. Modulators such as adenosine are difficult to study as once released they have a diffuse action (which can affect ...
Boris P. Klyuch, Mark J. Wall, Richardson, Magnus J. E., Klyuch, Boris P., Dale, Nicholas, Magnus J. E. Richardson, Wall, Mark J., Nicholas Dale   +7 more
core   +1 more source

Adenosine Receptors and Wound Healing

The Scientific World Journal, 2004
Recent studies have demonstrated that application of topical adenosine A2A receptor agonists promotes more rapid wound closure and clinical studies are currently underway to determine the utility of topical A2A adenosine receptor agonists in the therapy ...
Bruce N. Cronstein
doaj   +1 more source

Special Issue: Adenosine Receptors [PDF]

Molecules, 2017
Nearly 90 years ago, Drury and Szent-Györgyi revealed that adenosine produced profound hypotension and bradycardia, and it affected kidney function in mammals [1]. [...]
Francisco Ciruela, Eddy Sotelo
openaire   +4 more sources

Reversing adenosine-mediated immunosuppression in triple-negative breast cancer by synergistic chemo-immunotherapy via stimuli-responsive nanomedicinesResearch in context

EBioMedicine
Summary: Background: Chemotherapy remains the first-line treatment for triple-negative breast cancer (TNBC). Anthracycline chemotherapeutics, such as epirubicin (EPI), not only kill tumor cells but also induce immunogenic cell death (ICD).
Xinying Cheng, Hao Cai, Xue Li, Yuxin Zhang, Siying Li, Yunkun Li, Na Hu, Su Lui, Jing Jing, Qiyong Gong, Kui Luo   +10 more
doaj   +1 more source

Astrocytic adenosine receptor A2A and Gs-coupled signaling regulate memory

Nature Neuroscience, 2015
Astrocytes express a variety of G protein–coupled receptors and might influence cognitive functions, such as learning and memory. However, the roles of astrocytic Gs-coupled receptors in cognitive function are not known.
Anna G. Orr, E. Hsiao, M. M. Wang, Kaitlyn Ho, Daniel H. Kim, Xin Wang, Weikun Guo, Jing Kang, Gui-Qiu Yu, A. Adame, N. Devidze, D. Dubal, E. Masliah, B. Conklin, L. Mucke   +14 more
semanticscholar   +1 more source

ATP- and Adenosine-Mediated Signaling in the Central Nervous System: Adenosine Stimulates Glutamate Release From Astrocytes via A2a Adenosine Receptors

Journal of Pharmacological Sciences, 2004
Adenosine enhanced intracellular Ca2+ concentrations in astrocytes via A2a adenosine receptors involving protein kinase A (PKA) activation. The Ca2+ rise is inhibited by brefeldin A, an inhibitor of vesicular transport; but not by neomycin and U73122 ...
Tomoyuki Nishizaki
doaj   +1 more source

A depletable pool of adenosine in area CA1 of the rat hippocampus [PDF]

, 2001
Adenosine plays a major modulatory and neuroprotective role in the mammalian CNS. During cerebral metabolic stress, such as hypoxia or ischemia, the increase in extracellular adenosine inhibits excitatory synaptic transmission onto vulnerable neurons via
Darren Caldwell, Caldwell, Darren, Feruza Nuritova, Bruno G. Frenguelli, Dale, Nicholas, Pearson, Tim, Nuritova, Feruza, Frenguelli, Bruno G., Tim Pearson, Nicholas Dale   +9 more
core   +1 more source

Structure of the adenosine A2A receptor bound to an engineered G protein

Nature, 2016
G-protein-coupled receptors (GPCRs) are essential components of the signalling network throughout the body. To understand the molecular mechanism of G-protein-mediated signalling, solved structures of receptors in inactive conformations and in the active
B. Carpenter, R. Nehmé, T. Warne, A. G. Leslie, C. G. Tate   +4 more
semanticscholar   +1 more source

THE A3 ADENOSINE RECEPTOR: A LINK BETWEEN INFLAMMATION AND CANCER. [PDF]

, 2010
Adenosine is an endogenous and ubiquitous nucleoside that exerts many biological functions through interaction with 4 distinct subtypes of G protein-coupled receptors divided into A1, A2A, A2B, and A3.
Sacchetto, Valeria
core