Results 61 to 70 of about 4,325,962 (256)

Targeting Adenosine A2b Receptor Promotes Penile Rehabilitation of Refractory Erectile Dysfunction

Advanced Science
The mechanisms of adenosine and specific adenosine receptor subtypes in promoting penile rehabilitation remain unclear. Single‐cell RNA sequencing of human corpus cavernosum,  adenosine deaminase (ADA) and adenosine receptors knock‐out mice (ADA−/−, A1−/−
Yang Xiong, Feng Qin, Shanzun Wei, Xingliang Yang, Jun Li, Changjing Wu, Fuxun Zhang, Jiuhong Yuan   +7 more
doaj   +1 more source

Intracellular ATP concentration contributes to the cytotoxic and cytoprotective effects of adenosine. [PDF]

PLoS ONE, 2013
Extracellular adenosine (ADE) interacts with cells by two pathways: by activating cell surface receptors at nanomolar/micromolar concentrations; and by interfering with the homeostasis of the intracellular nucleotide pool at millimolar concentrations ...
Shujue Li, Xiaofen Li, Haiping Guo, Shouting Liu, Hongbiao Huang, Ningning Liu, Changshan Yang, Ping Tang, Jinbao Liu   +8 more
doaj   +1 more source

Adenosine-Metabolizing Enzymes, Adenosine Kinase and Adenosine Deaminase, in Cancer

Biomolecules, 2022
The immunosuppressive effect of adenosine in the microenvironment of a tumor is well established. Presently, researchers are developing approaches in immune therapy that target inhibition of adenosine or its signaling such as CD39 or CD73 inhibiting ...
Galina Zhulai, Eugenia Oleinik, Mikhail Shibaev, Kirill Ignatev   +3 more
doaj   +1 more source

The role of the large conductance Ca2+-activated K+ channel in adenosine receptor-mediated cytoprotection [PDF]

, 2009
The rat embryonic cardiomyoblast-derived H9c2 cell line is increasingly used for studies into cardioprotection, as these cells display similar properties to primary cardiomyocytes.
Fretwell, Laurice V, Fretwell, LV
core  

Wakefulness affects synaptic and network activity by increasing extracellular astrocyte-derived adenosine [PDF]

, 2012
Loss of sleep causes an increase in sleep drive and deficits in hippocampal-dependent memory. Both of these responses are thought to require activation of adenosine A1 receptors (adorA1Rs) and release of transmitter molecules including ATP, which is ...
Schmitt, L. Ian, R. E. Sims, Sims, Robert E., P. G. Haydon, Dale, Nicholas, Sims, Robert, Haydon, Philip G, L. I. Schmitt, N. Dale, Schmitt, L Ian   +9 more
core   +1 more source

Role of A1 adenosine receptor in cardiovascular diseases: Bridging molecular mechanisms with therapeutic opportunities

Experimental and Molecular Pathology
Adenosine serves as a critical homeostatic regulator, exerting influence over physiological and pathological conditions in the cardiovascular system.
Warisara Parichatikanond, Ratchanee Duangrat, Narawat Nuamnaichati, Supachoke Mangmool   +3 more
doaj   +1 more source

The Role of Adenosine Signaling in Headache: A Review

Brain Sciences, 2017
Migraine is the third most prevalent disease on the planet, yet our understanding of its mechanisms and pathophysiology is surprisingly incomplete. Recent studies have built upon decades of evidence that adenosine, a purine nucleoside that can act as a ...
Nathan T. Fried, Melanie B. Elliott, Michael L. Oshinsky   +2 more
doaj   +1 more source

The adenosine metabolite inosine is a functional agonist of the adenosine A2A receptor with a unique signaling bias

Cellular Signalling, 2016
Inosine is an endogenous purine nucleoside that is produced by catabolism of adenosine. Adenosine has a short half-life (approximately 10 s) and is rapidly deaminated to inosine, a stable metabolite with a half-life of approximately 15 h.
A. Welihinda, M. Kaur, Kelly Greene, Yongjiao Zhai, E. Amento   +4 more
semanticscholar   +1 more source

Using caffeine and other adenosine receptor antagonists and agonists as therapeutic tools against neurodegenerative diseases: A review

Life Science, 2014
Caffeine is the most consumed pychostimulant in the world, and it is known to affect basic and fundamental human processes such as sleep, arousal, cognition and learning and memory.
Marla Rivera-Oliver, Manuel Díaz-Ríos   +1 more
semanticscholar   +1 more source

Chemical Probes for the Adenosine Receptors [PDF]

Pharmaceuticals, 2019
Research on the adenosine receptors has been supported by the continuous discovery of new chemical probes characterized by more and more affinity and selectivity for the single adenosine receptor subtypes (A1, A2A, A2B and A3 adenosine receptors). Furthermore, the development of new techniques for the detection of G protein-coupled receptors (GPCR ...
Federico S., Lassiani L., Spalluto G.
openaire   +3 more sources