Results 31 to 40 of about 4,325,962 (256)

A population of immature cerebellar parallel fibre synapses are insensitive to adenosine but are inhibited by hypoxia [PDF]

, 2011
The purine adenosine plays an important role in a number of physiological and pathological processes and is neuroprotective during hypoxia and ischemia.
Mark J. Wall, Atterbury, Alison, Wall, Mark J., Alison Atterbury   +3 more
core   +1 more source

Synergistic Effects of Adenosine A2A Antagonist and L-DOPA on Rotational Behaviors in 6-Hydroxydopamine-Induced Hemi-Parkinsonian Mouse Model

Journal of Pharmacological Sciences, 2007
In this study, we examined the combination effects of L-DOPA and adenosine receptor antagonists on rotational behaviors in a hemi-Parkinsonian mouse model induced by unilateral 6-hydroxydopamine (6-OHDA) injection. The adenosine A2A antagonist SCH-58261,
Takahiro Matsuya, Kazuhiro Takuma, Kosuke Sato, Makoto Asai, Yoshihiro Murakami, Sosuke Miyoshi, Akihiro Noda, Taku Nagai, Hiroyuki Mizoguchi, Shintaro Nishimura, Kiyofumi Yamada   +10 more
doaj   +1 more source

Discovery of benzothiazolylquinoline conjugates as novel human A3 receptor antagonists: biological evaluations and molecular docking studies [PDF]

Royal Society Open Science, 2018
Adenosine is known as an endogenous purine nucleoside and it modulates a wide variety of physiological responses by interacting with adenosine receptors. Among the four adenosine receptor subtypes, the A3 receptor is of major interest in this study as it
Bidisha Sarkar, Santanu Maiti, Gajanan Raosaheb Jadhav, Priyankar Paira   +3 more
doaj   +1 more source

Targeting Adenosine Receptor Signaling in Cancer Immunotherapy

International Journal of Molecular Sciences, 2018
The immune system plays a major role in the surveillance and control of malignant cells, with the presence of tumor infiltrating lymphocytes (TILs) correlating with better patient prognosis in multiple tumor types. The development of ‘checkpoint blockade’
K. Sek, C. Mølck, Gregory D. Stewart, L. Kats, P. Darcy, P. Beavis   +5 more
semanticscholar   +1 more source

ATP- and Adenosine-Mediated Signaling in the Central Nervous System: Adenosine Receptor Activation by ATP Through Rapid and Localized Generation of Adenosine by Ecto-nucleotidases

Journal of Pharmacological Sciences, 2004
Extracellular ATP is now recognized as a neurotransmitter or neuromodilator in the nervous system, producing diverse physiological effects by activating multiple P2 receptors.
Isao Matsuoka, Satoko Ohkubo
doaj   +1 more source

Sleep-wake sensitive mechanisms of adenosine release in the basal forebrain of rodents : an in vitro study [PDF]

, 2013
Adenosine acting in the basal forebrain is a key mediator of sleep homeostasis. Extracellular adenosine concentrations increase during wakefulness, especially during prolonged wakefulness and lead to increased sleep pressure and subsequent rebound sleep.
Sims, Robert E., Houdini Ho Tin Wu, Tin Wu, Sims Robert Edward, Dale, Nicholas, Sims, Robert, Wu, Houdini Ho Tin, Houdini Ho, Dale Nicholas, Robert Edward Sims, Nicholas Dale, Wu Houdini Ho Tin   +11 more
core   +2 more sources

A Role for Adenosine A1 Receptors in GABA and NMDA-Receptor Mediated Modulation of Dopamine Release: Studies Using Fast Cyclic Voltammetry

Sensors, 2008
In the striatum many neurotransmitters including GABA, glutamate, acetylcholine, dopamine, nitric oxide and adenosine interact to regulate synaptic transmission. Dopamine release in the striatum is regulated by a number of pre- and postsynaptic receptors
Carmel O’Neill, John J. O’Connor   +1 more
doaj   +1 more source

Anti-Hair Loss Effect of Adenosine Is Exerted by cAMP Mediated Wnt/β-Catenin Pathway Stimulation via Modulation of Gsk3β Activity in Cultured Human Dermal Papilla Cells

Molecules, 2022
In the present study, we investigated the molecular mechanisms of adenosine for its hair growth promoting effect. Adenosine stimulated the Wnt/β-catenin pathway by modulating the activity of Gsk3β in cultured human dermal papilla cells. It also activated
Jaeyoon Kim, Jae Young Shin, Yun-Ho Choi, Nae Gyu Kang, Sanghwa Lee   +4 more
doaj   +1 more source

Evaluation of the Effects A2B Adenosine Receptor-Agonist (BAY 60–6583) in Induction of Apoptosis in ACHN Renal Cancer Cell Line

مجله دانشکده پزشکی اصفهان, 2018
Background: A2B adenosine receptor (A2BAR) is member of the family of seven transmembrane G protein coupled receptor that are activated in high concentration of extracellular adenosine that occur in certain pathophysiological conditions.
Abdol-Vahab Shafiee, Mohammadreza Sharifi   +1 more
doaj   +1 more source

Activity-dependent release of Adenosine: a critical re-evaluation of mechanism [PDF]

, 2008
Adenosine is perhaps the most important and universal modulator in the brain. The current consensus is that it is primarily produced in the extracellular space from the breakdown of previously released ATP.
Dale, Nicholas, Wall, Mark J.
core   +1 more source